Patents Assigned to Fondazione Santa Lucia
  • METHOD FOR ESTABLISHING THE PRESENCE AND PROGRESSION OF NEURODEGENERATIVE DISEASE
    Publication number: 20210048444
    Abstract: Disclosed is a method for detecting the presence, progression or risk of onset of neurodegenerative disease, based on determination of the concentration of lipid markers in an individuals serum or plasma sample.
    Type: Application
    Filed: November 6, 2018
    Publication date: February 18, 2021
    Applicants: Fondazione Istituto Italiano di Tecnologia, Fondazione Santa Lucia
    Inventors: Andrea Armirotti, Angelo Reggiani, Gianfranco Spalletta
  • DOMINANT NEGATIVE MUTANTS OF SAM68 FOR USE IN THE TREATMENT OF SPINAL MUSCULAR ATROPHY (SMA)
    Publication number: 20120071415
    Abstract: The present invention relates to the use of dominant negative mutants of Sam68 for the manufacture of a medicament for the treatment of spinal muscular atrophy, to nucleic acids coding for such mutants and to vectors and methods related thereto.
    Type: Application
    Filed: January 20, 2010
    Publication date: March 22, 2012
    Applicant: FONDAZIONE SANTA LUCIA
    Inventors: Maria Paola Paronetto, Simona Pedrotti
  • PEPTIDIC AND PEPTIDOMIMETIC COMPOUNDS FOR REGULATING AUTOPHAGY
    Publication number: 20110281804
    Abstract: The present invention relates to peptides, peptidomimetic compounds and pharmaceutical uses thereof for the treatment of neurodegenerative diseases or tumourigenesis and more specifically diseases deriving from the dysregulation of the signalling system of Ambra-1-mediated autophagy.
    Type: Application
    Filed: August 11, 2009
    Publication date: November 17, 2011
    Applicant: FONDAZIONE SANTA LUCIA
    Inventors: Maria Paola Paronetto, Gian Maria Fimia, Sabrina Di Bartolomeo
  • Use of P2Y purinoreceptor antagonist for the treatment of ischemia reperfusion
    Patent number: 6559148
    Abstract: Use of compounds modulating P2 purinoceptors, in particular antagonists such as Basilen Blue E-3G (Reactive Blue 2), for the prevention of the damages due to global cerebral ischemia and ischemia-reperfusion. Said compounds reduce the mortality in case of global cerebral ischemia as well as the neuronal damage of the hippocampus.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: May 6, 2003
    Assignees: Consiglio Nazionale delle Ricerche, Fondazione Santa Lucia
    Inventors: Cinzia Volonte′, Giuseppe Sancesario, Giorgio Bernardi