Patents Assigned to Fondazione Telethon
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Publication number: 20240131051Abstract: The present invention includes methods of treatment and/or prevention of fibrosis and of diseases associated with fibrosis by administering an, agent being selected from among: a combination of: miR-34b or a precursor or a mimic or a functional derivative thereof and miR-34c or a precursor or a mimic or a functional derivative thereof; or miR-34b or a precursor or a mimic or a functional derivative thereof or miR-34c or a precursor or a mimic or a functional derivative thereof.Type: ApplicationFiled: February 28, 2022Publication date: April 25, 2024Applicant: FONDAZIONE TELETHON ETSInventors: Nicola BRUNETTI PIERRI, Pasquale PICCOLO, Rosa FERRIERO
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Patent number: 11957713Abstract: The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.Type: GrantFiled: October 16, 2017Date of Patent: April 16, 2024Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, OSPEDALE SAN RAFFAELE S.R.L., POLITECNICO DI MILANO, FONDAZIONE TELETHON ETS, DANA-FARBER CANCER INSTITUTE, INCInventors: Alessandra Biffi, Marco Peviani, Davide Moscatelli, Alessia Capotondo, Rita Milazzo, Umberto Capasso Palmiero
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Patent number: 11957747Abstract: An enveloped viral particle producer or packaging cell, wherein the cell is genetically engineered to decrease expression of MHC-I on the surface of the cell.Type: GrantFiled: January 7, 2021Date of Patent: April 16, 2024Assignees: Ospedale San Raffaele S.r.l., Fondazione Telethon ETSInventors: Alessio Cantore, Angelo Leone Lombardo, Luigi Naldini
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Patent number: 11753643Abstract: A gene vector comprising a miRNA sequence target.Type: GrantFiled: June 10, 2018Date of Patent: September 12, 2023Assignees: OSPEDALE SAN RAFFAELE S.R.L., FONDAZIONE TELETHONInventors: Luigi Naldini, Brian Brown
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Patent number: 11548936Abstract: The present invention provides compositions and methods for the treatment or prevention of a lysosomal disease or disorder involving increasing the level, expression, or activity of a metallothionein polypeptide or polynucleotide in the subject.Type: GrantFiled: January 16, 2018Date of Patent: January 10, 2023Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, OSPEDALE SAN RAFFAELE S.R.L., DANA-FARBER CANCER INSTITUTE, INC., FONDAZIONE TELETHONInventors: Alessandra Biffi, Eleonora Cavalca
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Patent number: 11427836Abstract: An RNA interference (RNAi) strategy is provided based on use of artificial microRNA (amiR) to reduce NKCC1 expression. In particular, a method is provided that achieves neuron-specific expression of specific amiR against NKCC1 by using a human Synapsin promoter to drive transgene expression.Type: GrantFiled: April 11, 2018Date of Patent: August 30, 2022Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITE D'EVRY-VAL-D'ESSONNE, GENETHON, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, FONDAZIONE TELETHONInventors: Federico Mingozzi, Giuseppe Ronzitti, Andrea Contestabile, Laura Cancedda
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Patent number: 11407996Abstract: A gene vector for use in gene therapy comprising at least one miRNA sequence target operably linked to a nucleotide sequence having a corresponding miRNA in a hematopoietic progenitor cell (HSPC) or hematopoietic stem cell (HSC) which prevents or reduces expression of the nucleotide sequence in a HSPC or HSC but not in a differentiated cell.Type: GrantFiled: April 15, 2019Date of Patent: August 9, 2022Assignees: Ospedale San Raffaele S.r.l., Fondazione TelethonInventors: Alessandra Biffi, Bernhard Rudolf Gentner, Luigi Naldini
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Patent number: 11360087Abstract: Use of (i) an anti-CD3 antibody, (ii) an anti-CD56 antibody, (iii) an anti-CD14 antibody, (iv) an anti-CD38 antibody, (v) an anti-CD45 antibody, (vi) an anti-CD90 antibody, (vii) an anti-CD135 antibody, (viii) an anti-CD10 antibody, (ix) an anti-CD11c antibody, (x) an anti-CD19 antibody, (xi) an anti-CD34 antibody, (xii) an anti-CD45RA antibody, (xiii) an anti-CD7 antibody, (xiv) an anti-CD71 antibody, (xv) an anti-CD41/CD61 complex antibody or an anti-CD41 antibody and/or an anti-CD61 antibody (xvi) an anti-CD33 antibody and/or an anti-CD66b antibody, for identifying hematopoietic cell subtypes in an isolated sample, determining the relative frequency of hematopoietic cell subtypes in an isolated sample and/or quantifying the number of cells within hematopoietic cell subtypes in an isolated sample, wherein each of (i) to (xvi) is labelled with a different fluorochrome, wherein when (xvi) is an anti-CD33 antibody and an anti-CD66b antibody, the anti-CD33 antibody and anti-CD66b are labelled with the same fluoType: GrantFiled: October 17, 2017Date of Patent: June 14, 2022Assignees: Ospedale San Raffaele S.R.L., Fondazione TelethonInventors: Luca Basso-Ricci, Luca Biasco, Alessandro Aiuti
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Publication number: 20220160749Abstract: The present invention relates to agents capable to inhibit miR-181, for use in treatment and/or prevention of mitochondrial disorders including mitochondrial diseases with eye and/or brain involvement and neurodegeneration affecting eye and/or brain associated with mitochondrial dysfunction.Type: ApplicationFiled: April 23, 2019Publication date: May 26, 2022Applicant: FONDAZIONE TELETHONInventors: Sandro BANFI, Brunella FRANCO, Alessia INDRIERI, Sabrina CARRELLA
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Publication number: 20220001030Abstract: The present invention relates to a method of integrating an exogenous DNA sequence into a genome of a cell comprising contacting the cell with: a) a donor nucleic acid comprising: —at least one STOP codon and a translation initiation sequence (TIS) or —a ribosomal skipping sequence, and —said exogenous DNA sequence wherein said donor nucleic acid is flanked at 5? and 3? by inverted targeting sequences; b) a complementary strand oligonucleotide homologous to the targeting sequence and c) a nuclease that recognizes the targeting sequence.Type: ApplicationFiled: October 15, 2019Publication date: January 6, 2022Applicant: FONDAZIONE TELETHONInventors: Alberto AURICCHIO, Manel LLADO SANTAEULARIA
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Publication number: 20220002295Abstract: The present invention relates to heterocyclic nitrogen compounds, use thereof as a medicament and pharmaceutical compositions thereof. Furthermore, the invention provides combinations of compounds of general formula (I) with therapeutic agents, such as correctors, potentiators and amplifiers of dysfunctional proteins.Type: ApplicationFiled: November 20, 2019Publication date: January 6, 2022Applicants: FONDAZIONE TELETHON, UNIVERSITA DEGLI STUDI DI PALERMOInventors: Paola BARRAJA, Ilaria MUSANTE, Luis Juan Vicente GALIETTA, Virginia SPANO'
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Publication number: 20210277354Abstract: The present disclosure relates to a genetically modified dendritic cell or precursor thereof expressing at least one anti-gen-derived peptide and at least one immuno-modulatory molecule, its medical use and method of preparation. The invention also relates to an in vitro method to produce IL-10-producing CD49b+LAG-3+ Tr1 cells or antigen-specific FOXP3+ T cells and relative medical uses and pharmaceutical compositions.Type: ApplicationFiled: June 19, 2019Publication date: September 9, 2021Applicants: FONDAZIONE TELETHON, FONDAZIONE CENTRO SAN RAFFAELE, OSPEDALE SAN RAFFAELE S.R.L.Inventors: Andrea ANNONI, Silvia Adriana GREGORI
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Patent number: 11098094Abstract: The present invention relates to proteins consisting of an artificial DNA-binding domain (DBD) and related molecules and uses thereof. In particular, the proteins are ZF-DBD or TALE-DBD and are used for the treatment of eye disorders caused by gain of function mutation. The disorder may be ADRP, in particular ADRP caused by mutation in the rhodopsin gene. The present invention also relates to a method to identify cis-regulatory elements and to modulate them via DBDs.Type: GrantFiled: November 20, 2014Date of Patent: August 24, 2021Assignee: FONDAZIONE TELETHONInventors: Salvatore Botta, Enrico Maria Surace, Elena Marrocco
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Patent number: 11096955Abstract: The present invention relates to the treatment and/or prevention of a retinal disease by using a polynucleotide promoter wherein the polynucleotide or a variant thereof consists of the sequence (hRHOs-wt;?SEQ?ID?NO.?1) TCCTCCTAGTGTCACCTTGGCCCCTCTTAGAAGCCAATTAGGCCCTCAG TTTCTGCAGCGGGGATTAATATGATTATGAACACCCCCAATCTCCCAGA TGCTGATTCAGCCAGGAGCTTAGGAGGGGGAGGTCACTTTATAAGGGTC TGGGGGGGTCAGAACCCAGAGTCATCCAGCTGGAGCCCTGAGTGGCTGA GCTCAGGCCTTCGCAGCATTCTTGGGTGGGAGCAGCCACGGGTCAGCCA CAAGGGCCACAGCC? wherein the fragment TGAACACCCCCAATCTCCCAGATGCT which is the sequence from nucleotide 77 to nucleotide 102 of SEQ ID NO. 1, is substituted. The invention is also directed to the use of relative vector, vector systems, host cells and pharmaceutical compositions.Type: GrantFiled: February 9, 2017Date of Patent: August 24, 2021Assignee: Fondazione TelethonInventors: Enrico Maria Surace, Mariangela Lupo, Salvatore Botta, Elena Marrocco, Nicola De Prisco
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Publication number: 20210052611Abstract: In various embodiments methods are provided for the treatment or prophylaxis of liposomal storage diseases. In certain embodiments the methods involve administering to a subject in need thereof one or more molecular tweezers that inhibit protein aggregation.Type: ApplicationFiled: April 25, 2019Publication date: February 25, 2021Applicants: The Regents of the University of California, Fondazione Telethon, Fondazione TelethonInventors: Gal Bitan, Alessandro Fraldi, Irene Sambri, Antonio Monaco
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Patent number: 10912824Abstract: An enveloped viral particle producer or packaging cell, wherein the cell is genetically engineered to decrease expression of MHC-I on the surface of the cell.Type: GrantFiled: July 13, 2015Date of Patent: February 9, 2021Assignees: Ospedale San Raffaele S.r.l., Fondazione TelethonInventors: Alessio Cantore, Angelo Leone Lombardo, Luigi Naldini
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Publication number: 20200182870Abstract: Use of (i) an anti-CD3 antibody, (ii) an anti-CD56 antibody, (iii) an anti-CD14 antibody, (iv) an anti-CD38 antibody, (v) an anti-CD45 antibody, (vi) an anti-CD90 antibody, (vii) an anti-CD135 antibody, (viii) an anti-CD10 antibody, (ix) an anti-CD11c antibody, (x) an anti-CD19 antibody, (xi) an anti-CD34 antibody, (xii) an anti-CD45RA antibody, (xiii) an anti-CD7 antibody, (xiv) an anti-CD71 antibody, (xv) an anti-CD41/CD61 complex antibody or an anti-CD41 antibody and/or an anti-CD61 antibody (xvi) an anti-CD33 antibody and/or an anti-CD66b antibody, for identifying hematopoietic cell subtypes in an isolated sample, determining the relative frequency of hematopoietic cell subtypes in an isolated sample and/or quantifying the number of cells within hematopoietic cell subtypes in an isolated sample, wherein each of (i) to (xvi) is labelled with a different fluorochrome, wherein when (xvi) is an anti-CD33 antibody and an anti-CD66b antibody, the anti-CD33 antibody and anti-CD66b are labelled with the same fluoType: ApplicationFiled: October 17, 2017Publication date: June 11, 2020Applicants: Ospedale San Raffaele S.r.l., Fondazione TelethonInventors: Luca BASSO-RICCI, Luca BIASCO, Alessandro AIUTI
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Patent number: 10617721Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.Type: GrantFiled: October 24, 2014Date of Patent: April 14, 2020Assignees: OSPEDALE SAN RAFFAELE S.R.L., FONDAZIONE TELETHONInventors: Luigi Naldini, Bernhard Rudolf Gentner, Erika Zonari, Francesco Boccalatte
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Publication number: 20200038439Abstract: The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.Type: ApplicationFiled: October 16, 2017Publication date: February 6, 2020Applicants: CHILDREN'S MEDICAL CENTER CORPORATION, OSPEDALE SAN RAFFAELE S.R.L., POLITECNICO DI MILANO, FONDAZIONE TELETHONInventors: ALESSANDRA BIFFI, MARCO PEVIANI, DAVIDE MOSCATELLI, ALESSIA CAPATANDO, RITA MILAZZO, UMBERTO CAPASSO PALMIERO
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Patent number: 10494645Abstract: The present invention relates to constructs, vectors, relative host cells and pharmaceutical compositions which allow an effective gene therapy, in particular of genes larger than 5 Kb.Type: GrantFiled: April 18, 2014Date of Patent: December 3, 2019Assignee: FONDAZIONE TELETHONInventors: Alberto Auricchio, Pasqualina Colella, Ivana Trapani