Patents Assigned to FONDAZIONE TELETHON ETS
  • USE OF MICRORNAS IN THE TREATMENT OF FIBROSIS
    Publication number: 20240131051
    Abstract: The present invention includes methods of treatment and/or prevention of fibrosis and of diseases associated with fibrosis by administering an, agent being selected from among: a combination of: miR-34b or a precursor or a mimic or a functional derivative thereof and miR-34c or a precursor or a mimic or a functional derivative thereof; or miR-34b or a precursor or a mimic or a functional derivative thereof or miR-34c or a precursor or a mimic or a functional derivative thereof.
    Type: Application
    Filed: February 28, 2022
    Publication date: April 25, 2024
    Applicant: FONDAZIONE TELETHON ETS
    Inventors: Nicola BRUNETTI PIERRI, Pasquale PICCOLO, Rosa FERRIERO
  • Compositions and methods for treating diseases and disorders of the central nervous system
    Patent number: 11957713
    Abstract: The present invention provides compositions and methods for the treatment or prevention of a neurological disease or disorder of the central nervous system (e.g., a storage disorder, lysosomal storage disorder, neurodegenerative disease, etc.) by reconstitution of brain myeloid cell and microglia upon transplantation of hematopoietic cells enriched in microglia reconstitution potential. The invention also provides compositions and methods for ablating and reconstituting microglia.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: April 16, 2024
    Assignees: CHILDREN'S MEDICAL CENTER CORPORATION, OSPEDALE SAN RAFFAELE S.R.L., POLITECNICO DI MILANO, FONDAZIONE TELETHON ETS, DANA-FARBER CANCER INSTITUTE, INC
    Inventors: Alessandra Biffi, Marco Peviani, Davide Moscatelli, Alessia Capotondo, Rita Milazzo, Umberto Capasso Palmiero
  • Vector production
    Patent number: 11957747
    Abstract: An enveloped viral particle producer or packaging cell, wherein the cell is genetically engineered to decrease expression of MHC-I on the surface of the cell.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: April 16, 2024
    Assignees: Ospedale San Raffaele S.r.l., Fondazione Telethon ETS
    Inventors: Alessio Cantore, Angelo Leone Lombardo, Luigi Naldini