Abstract: The present invention provides: a complex comprising a genome editing enzyme and a cell membrane-permeable peptide(CPP), wherein the CPP is fused to the genome editing enzyme; a complex comprising a genome editing enzyme, a target gene-specific nucleic acid, and a CPP, wherein the CPP is fused to the genome editing enzyme and/or the a target gene-specific nucleic acid; the complex comprising a polycationic moiety fused to the CPP, wherein the polycation moiety is statically bound to the target gene-specific nucleic acid; a genome editing method using the complex; and a kit for genome-editing, the kit including these complexes.

Abstract: A tool device has a deceleration unit, a tip tool, and a reaction bar. The deceleration unit increases a torque that is input to the deceleration unit. The tip tool is rotated when receiving a motive force from the deceleration unit. The reaction bar is fixed to the deceleration unit. An external force can be made to act on the reaction bar to receive a reaction force that is generated during rotation of the tip tool.