Abstract: The present invention relates to fusion proteins of ACE2 with IgM or IgG2 Fc and the medical use of these fusion proteins, in particular in the prevention or treatment of infections with coronaviruses such as SARS-CoV-2.
Type:
Application
Filed:
July 29, 2022
Publication date:
March 13, 2025
Applicant:
Formycon AG
Inventors:
Johann Sebastian BUCHNER, Hristo Lyubomirov SVILENOV
Abstract: The present invention relates to fusion proteins of ACE2 with IgG Fc and the medical use of these fusion proteins, in particular in the prevention or treatment of infections with coronaviruses such as SARS-CoV-2, as well as methods of producing them.
Abstract: The present invention relates to pharmaceutical compositions of an anti-PD1 antibody comprising acitrate buffer, one or more amino acids other than histidine and a surfactant.
Abstract: The present invention relates to pharmaceutical compositions of ACE2 Fc fusion proteins and therapeutic uses thereof, in particular in the treatment of infections with SARS-CoV-2.
Abstract: A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.
Type:
Grant
Filed:
February 26, 2022
Date of Patent:
June 6, 2023
Assignees:
FORMYCON AG, SIO2 MEDICAL PRODUCTS, INC., KLINGE BIOPHARMA GMBH
Inventors:
Carsten Brockmeyer, Christopher Weikart, Murray Stephen Bennett, Jean-Pierre Giraud, Thomas Strungmann
Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.
Abstract: A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.
Type:
Grant
Filed:
January 21, 2021
Date of Patent:
April 12, 2022
Assignees:
FORMYCON AG, SIO2 MEDICAL PRODUCTS, INC., KLINGE BIOPHARMA GMBH
Inventors:
Carsten Brockmeyer, Christopher Weikart, Murray Stephen Bennett, Jean-Pierre Giraud, Thomas Strungmann
Abstract: The present invention relates to liquid pharmaceutical compositions of a VEGF antagonist for intravitreal administration comprising a histidine buffer, an inorganic salt, a carbohydrate and a polysorbate.
Abstract: The present invention relates to liquid pharmaceutical formulations for intravitreal injection of an anti-VEGF antibody which does not contain saccharides for use in the treatment of age-related macular degeneration.
Abstract: The present invention relates to liquid pharmaceutical compositions of a VEGF antagonist for intravitreal administration comprising a histidine buffer, an inorganic salt, a carbohydrate and a polysorbate.
Abstract: The present invention relates to a pre-filled syringe containing a VEGF antagonist and comprising a plastic barrel which is silicone-free, kits comprising this syringe and the use of the syringe for the administration of a VEGF antagonist in the treatment of ocular diseases.