Patents Assigned to Forschungszentrum Borstel
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Patent number: 11360085Abstract: Herein is reported a method for determining bacterial endotoxin at low concentrations in a sample of an antibody (that has been produced using bacterial cells) comprising the following steps in the following order: i) adding magnesium ions to the sample, ii) diluting the sample, iii) dialyzing the sample having a pH-value of 5.7-8.0 against an endotoxin-flee aqueous solution, and iv) determining bacterial endotoxin in the sample using a bacterial endotoxin test, particularly the Limulus amoebocyte lysate assay.Type: GrantFiled: January 28, 2020Date of Patent: June 14, 2022Assignees: Forschungszentrum Borstel Leibniz Lungenzentrum, Hoffmann-La Roche Inc.Inventors: Christian Alexander, Sven Deutschmann, Pierre Lang, Friedrich Von Wintzingerode, Ulrich Zaehringer
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Patent number: 11179407Abstract: The present invention relates to L-arabino-oligosaccharides, in particular synthetically produced L-arabino-oligosaccharides and their uses for the prophylaxis of allergic reactions in mammals.Type: GrantFiled: November 30, 2016Date of Patent: November 23, 2021Assignees: FORSCHUNGSZENTRUM BORSTEL LEIBNIZ-ZENTRUM FÜR MEDIZIN UND BIOWISSENSHAFTEN, UNIVERSITÄT ROSTOCK, RUHR-UNIVERSITÄT BOCHUMInventors: Marcus Peters, Otto Holst, Christian Vogel, Alice Voss
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Patent number: 10585097Abstract: Herein is reported a method for determining bacterial endotoxin at low concentrations in a sample of an antibody (that has been produced using bacterial cells) comprising the following steps in the following order: i) adding magnesium ions to the sample, ii) diluting the sample, iii) dialyzing the sample having a pH-value of 5.7-8.0 against an endotoxin-free aqueous solution, and iv) determining bacterial endotoxin in the sample using a bacterial endotoxin test, particularly the limulus amoebocyte lysate assay.Type: GrantFiled: July 27, 2016Date of Patent: March 10, 2020Assignees: Forschungszentrum Borstel Leibniz Lungerzentrum, Hoffmann-La Roche Inc.Inventors: Christian Alexander, Sven Deutschmann, Pierre Lang, Friedrich Von Wintzingerode, Ulrich Zaehringer
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Patent number: 9950017Abstract: The present invention relates to a pharmaceutical composition which includes naturally occurring, non-transgenic isolated bacteria from the group of Lactococcus and Acinetobacter or fragments thereof or mixtures thereof, to such a bacterium as a medicament for the prevention and/or treatment of allergic or chronic inflammatory disorders and to a process for producing this composition.Type: GrantFiled: March 3, 2008Date of Patent: April 24, 2018Assignees: FORSCHUNGSZENTRUM BORSTEL, RUHR-UNIVERSITÄT BOCHUMInventors: Albrecht Bufe, Otto Holst, Harald Renz, Erika Von Mutius, Johann Bauer, Nicole Blumer, Jennifer Debarry, Markus Ege, Susanne Friedrich, Holger Garn, Soren Gatermann, Anna Hanuszkiewicz, Holger Heine, Michael Wegmann
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Patent number: 9750796Abstract: The present invention relates to enterococcal cell wall polymers and their uses in the prevention and therapy of bacterial infection.Type: GrantFiled: March 4, 2013Date of Patent: September 5, 2017Assignees: UNIVERSITAETSKLINKUM FREIBURG, FORSCHUNGSZENTRUM BORSTELInventors: Johannes Huebner, Otto Holst, Christian Theilacker, Karolina Kruszynska, Stefan Geiss-Liebisch, Agnieszka Beczala
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Patent number: 9636472Abstract: The present invention relates to a method for the ventilation of a living being (3), the respiration airflow (v) flowing into the living being (3) and out of the living being (3) being detected, it being ascertained from the detected respiration airflow (v) whether an inhalation phase or an exhalation phase is present, and the air pressure (p) in a respiratory organ of the living being (3) being regulated, characterized in that, upon recognition of an inhalation phase, the air pressure (p) in the respiratory organ is raised at the beginning of the inhalation phase and lowered again with progressing respiration cycle.Type: GrantFiled: February 18, 2011Date of Patent: May 2, 2017Assignee: Forschungszentrum Borstel Liebniz-Zentrum fuer Medizin und BiowissenschaftenInventors: Stephan Rueller, Susanne Greve
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Patent number: 9375444Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.Type: GrantFiled: October 21, 2013Date of Patent: June 28, 2016Assignees: PROTECTIMMUN GMBH, FORSCHUNGSZENTRUM BORSTELInventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holst
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Patent number: 9255157Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.Type: GrantFiled: May 25, 2012Date of Patent: February 9, 2016Assignees: Universitaetsklinikum Freiburg, Forschungszentrum BorstelInventors: Johannes Hübner, Christian Theilacker, Zbigniew Kaczynski, Otto Holst
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Patent number: 9005622Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.Type: GrantFiled: January 19, 2010Date of Patent: April 14, 2015Assignees: Forschungszentrum Borstel, Universitätsklinikum FreiburgInventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
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Publication number: 20140161792Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.Type: ApplicationFiled: May 25, 2012Publication date: June 12, 2014Applicants: FORSCHUNGSZENTRUM BORSTEL, UNIVERSIT TSKLINIKUM FREIBURGInventors: Johannes Hübner, Christian Theilacker, Zbignew Kacynski, Otto Holst
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Publication number: 20140154290Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.Type: ApplicationFiled: October 21, 2013Publication date: June 5, 2014Applicants: FORSCHUNGSZENTRUM BORSTEL, PROTECTIMMUN GMBHInventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holst
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Patent number: 8501199Abstract: The present invention concerns novel synthetic blocking reagents for the reduction of non-specific bindings in solid phase assays that rely on biological and specific recognition, e.g., in enzyme-linked immunosorbent assays (ELISAs). The invention provides the use of compounds as blocking reagents as well as kits comprising these compounds. The compounds comprise one or more poly(ethylene glycol) moieties, one or more alkyl- or aminoalkyl groups and another unit bridging the aforementioned groups, wherein the compound comprises at least one amino group.Type: GrantFiled: June 10, 2010Date of Patent: August 6, 2013Assignee: Forschungszentrum BorstelInventors: Naho Fujimoto, Niels Röckendorf, Steffen Bade, Katrin Ramaker, Andreas Frey
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Publication number: 20120128597Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.Type: ApplicationFiled: August 14, 2009Publication date: May 24, 2012Applicants: Forschungszentrum Borstel, Protectimmun GmbHInventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holt
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Publication number: 20110201023Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.Type: ApplicationFiled: August 6, 2009Publication date: August 18, 2011Applicants: UNIVERSITATSKLINKUM HAMBURGEPPENDORF, FORSCHUNGSZENTRUM BORSTELInventors: Thomas Braulke, Sven Müller-Loennies
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Patent number: 7601812Abstract: The invention relates to active agents from parasitic worms, in particular Schistosoma mansoni, which induce a T-helper type 2 response (Th2 immune response).Type: GrantFiled: March 1, 2002Date of Patent: October 13, 2009Assignee: Forschungszentrum Borstel Zentrum fur Medizin und BiowissenschaftenInventors: Gabriele Schramm, Helmut Haas, Franco Falcone, Achim Gronow, Karin Haisch
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Patent number: 6743606Abstract: The invention relates to a protein which presents identical or different catalytically active domains of glycosyltransferases and has a processive action. In particular, the same protein is successively active in at least two successive process steps.Type: GrantFiled: September 22, 2000Date of Patent: June 1, 2004Assignees: Gesellschaft Für Erwerb und Verwertung von Schutzrechten-GVS mbH, Forschungszentrum BorstelInventors: Frank P. Wolter, Petra Jorasch, Ernst Heinz, Ulrich Zähringer