Patents Assigned to Forschungszentrum Borstel
  • Patent number: 11360085
    Abstract: Herein is reported a method for determining bacterial endotoxin at low concentrations in a sample of an antibody (that has been produced using bacterial cells) comprising the following steps in the following order: i) adding magnesium ions to the sample, ii) diluting the sample, iii) dialyzing the sample having a pH-value of 5.7-8.0 against an endotoxin-flee aqueous solution, and iv) determining bacterial endotoxin in the sample using a bacterial endotoxin test, particularly the Limulus amoebocyte lysate assay.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: June 14, 2022
    Assignees: Forschungszentrum Borstel Leibniz Lungenzentrum, Hoffmann-La Roche Inc.
    Inventors: Christian Alexander, Sven Deutschmann, Pierre Lang, Friedrich Von Wintzingerode, Ulrich Zaehringer
  • Patent number: 11179407
    Abstract: The present invention relates to L-arabino-oligosaccharides, in particular synthetically produced L-arabino-oligosaccharides and their uses for the prophylaxis of allergic reactions in mammals.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: November 23, 2021
    Assignees: FORSCHUNGSZENTRUM BORSTEL LEIBNIZ-ZENTRUM FÜR MEDIZIN UND BIOWISSENSHAFTEN, UNIVERSITÄT ROSTOCK, RUHR-UNIVERSITÄT BOCHUM
    Inventors: Marcus Peters, Otto Holst, Christian Vogel, Alice Voss
  • Patent number: 10585097
    Abstract: Herein is reported a method for determining bacterial endotoxin at low concentrations in a sample of an antibody (that has been produced using bacterial cells) comprising the following steps in the following order: i) adding magnesium ions to the sample, ii) diluting the sample, iii) dialyzing the sample having a pH-value of 5.7-8.0 against an endotoxin-free aqueous solution, and iv) determining bacterial endotoxin in the sample using a bacterial endotoxin test, particularly the limulus amoebocyte lysate assay.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: March 10, 2020
    Assignees: Forschungszentrum Borstel Leibniz Lungerzentrum, Hoffmann-La Roche Inc.
    Inventors: Christian Alexander, Sven Deutschmann, Pierre Lang, Friedrich Von Wintzingerode, Ulrich Zaehringer
  • Patent number: 9950017
    Abstract: The present invention relates to a pharmaceutical composition which includes naturally occurring, non-transgenic isolated bacteria from the group of Lactococcus and Acinetobacter or fragments thereof or mixtures thereof, to such a bacterium as a medicament for the prevention and/or treatment of allergic or chronic inflammatory disorders and to a process for producing this composition.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: April 24, 2018
    Assignees: FORSCHUNGSZENTRUM BORSTEL, RUHR-UNIVERSITÄT BOCHUM
    Inventors: Albrecht Bufe, Otto Holst, Harald Renz, Erika Von Mutius, Johann Bauer, Nicole Blumer, Jennifer Debarry, Markus Ege, Susanne Friedrich, Holger Garn, Soren Gatermann, Anna Hanuszkiewicz, Holger Heine, Michael Wegmann
  • Patent number: 9750796
    Abstract: The present invention relates to enterococcal cell wall polymers and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: September 5, 2017
    Assignees: UNIVERSITAETSKLINKUM FREIBURG, FORSCHUNGSZENTRUM BORSTEL
    Inventors: Johannes Huebner, Otto Holst, Christian Theilacker, Karolina Kruszynska, Stefan Geiss-Liebisch, Agnieszka Beczala
  • Patent number: 9636472
    Abstract: The present invention relates to a method for the ventilation of a living being (3), the respiration airflow (v) flowing into the living being (3) and out of the living being (3) being detected, it being ascertained from the detected respiration airflow (v) whether an inhalation phase or an exhalation phase is present, and the air pressure (p) in a respiratory organ of the living being (3) being regulated, characterized in that, upon recognition of an inhalation phase, the air pressure (p) in the respiratory organ is raised at the beginning of the inhalation phase and lowered again with progressing respiration cycle.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: May 2, 2017
    Assignee: Forschungszentrum Borstel Liebniz-Zentrum fuer Medizin und Biowissenschaften
    Inventors: Stephan Rueller, Susanne Greve
  • Patent number: 9375444
    Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: June 28, 2016
    Assignees: PROTECTIMMUN GMBH, FORSCHUNGSZENTRUM BORSTEL
    Inventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holst
  • Patent number: 9255157
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: February 9, 2016
    Assignees: Universitaetsklinikum Freiburg, Forschungszentrum Borstel
    Inventors: Johannes Hübner, Christian Theilacker, Zbigniew Kaczynski, Otto Holst
  • Patent number: 9005622
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: April 14, 2015
    Assignees: Forschungszentrum Borstel, Universitätsklinikum Freiburg
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Publication number: 20140161792
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 12, 2014
    Applicants: FORSCHUNGSZENTRUM BORSTEL, UNIVERSIT TSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Christian Theilacker, Zbignew Kacynski, Otto Holst
  • Publication number: 20140154290
    Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.
    Type: Application
    Filed: October 21, 2013
    Publication date: June 5, 2014
    Applicants: FORSCHUNGSZENTRUM BORSTEL, PROTECTIMMUN GMBH
    Inventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holst
  • Patent number: 8501199
    Abstract: The present invention concerns novel synthetic blocking reagents for the reduction of non-specific bindings in solid phase assays that rely on biological and specific recognition, e.g., in enzyme-linked immunosorbent assays (ELISAs). The invention provides the use of compounds as blocking reagents as well as kits comprising these compounds. The compounds comprise one or more poly(ethylene glycol) moieties, one or more alkyl- or aminoalkyl groups and another unit bridging the aforementioned groups, wherein the compound comprises at least one amino group.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: August 6, 2013
    Assignee: Forschungszentrum Borstel
    Inventors: Naho Fujimoto, Niels Röckendorf, Steffen Bade, Katrin Ramaker, Andreas Frey
  • Publication number: 20120128597
    Abstract: A prophylactic antiallergenic composition includes at least one arabinogalactan or arabinogalactan protein. The arabinogalactan or arabinogalactan protein is isolated from a grass or corresponds in its structural arrangement to an arabinogalactan that can be isolated from a grass.
    Type: Application
    Filed: August 14, 2009
    Publication date: May 24, 2012
    Applicants: Forschungszentrum Borstel, Protectimmun GmbH
    Inventors: Marcus Peters, Marion Kauth, Albrecht Bufe, Otto Holt
  • Publication number: 20110201023
    Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof which specifically binds to mannose 6-phosphate and methods for preparing such antibody or antigen-binding fragment thereof. The invention further relates to a nucleic acid molecule encoding such antibody or antibody fragment, an expression vector comprising such nucleic acid molecule and a host cell comprising such nucleic acid molecule or expression vector. The invention also relates to a method for purifying or concentrating a target molecule comprising at least one mannose 6-phosphate residue from a sample. In another aspect, the invention relates to a method for diagnosing a disease which is characterized by an absent or reduced modification of molecules with mannose 6-phosphate residues.
    Type: Application
    Filed: August 6, 2009
    Publication date: August 18, 2011
    Applicants: UNIVERSITATSKLINKUM HAMBURGEPPENDORF, FORSCHUNGSZENTRUM BORSTEL
    Inventors: Thomas Braulke, Sven Müller-Loennies
  • Patent number: 7601812
    Abstract: The invention relates to active agents from parasitic worms, in particular Schistosoma mansoni, which induce a T-helper type 2 response (Th2 immune response).
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: October 13, 2009
    Assignee: Forschungszentrum Borstel Zentrum fur Medizin und Biowissenschaften
    Inventors: Gabriele Schramm, Helmut Haas, Franco Falcone, Achim Gronow, Karin Haisch
  • Patent number: 6743606
    Abstract: The invention relates to a protein which presents identical or different catalytically active domains of glycosyltransferases and has a processive action. In particular, the same protein is successively active in at least two successive process steps.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: June 1, 2004
    Assignees: Gesellschaft Für Erwerb und Verwertung von Schutzrechten-GVS mbH, Forschungszentrum Borstel
    Inventors: Frank P. Wolter, Petra Jorasch, Ernst Heinz, Ulrich Zähringer