Abstract: Disclosed herein are methods of treating cancer. Some such methods include administration of a first anti-cancer agent that increases CD46 expression on the surface of a cancer cell. Some embodiments include administration of a second anti-cancer agent that binds CD46. The second anti-cancer agent may include an immunoconjugate comprising a CD46 binding domain and effector agent.
Type:
Application
Filed:
January 6, 2022
Publication date:
February 22, 2024
Applicants:
Fortis Therapeutics, Inc., The Regents of the University of California
Inventors:
Bin LIU, Andrew DORR, Jay LICHTER, Marc NASOFF, Leonard POST
Abstract: Disclosed herein are immunoconjugates comprising a CD46 binding domain and effector agent. Further provided herein are methods of treating cancer comprising administering to a subject having cancer a pharmaceutical composition comprising immunoconjugates comprising a CD46 binding domain and effector agent.