Abstract: An aqueous pharmaceutical composition comprising: a) 0.005 to 10% by wt of one or more water-soluble pharmaceutically active ingredients or pharmaceutically acceptable salts thereof; b) from 0.01 to 10% by wt hydroxypropyl methyl cellulose having a viscosity of from 2500 to 5500 cps (mPa·s); and c) a buffer for maintaining the pH of the aqueous pharmaceutical composition from 5 to 7; can be prepared by a method which comprises: i) dissolving the above components in water to form an aqueous solution, and ii) filtering the aqueous solution formed in i) through a sieve having a mesh size from ?1 micron but ?10 microns. The compositions obtainable by this method are capable of demonstrating improved mucoadhesive consistency and stability.