Abstract: The invention relates to the method for preparation of orally administrated insulin oil formulation comprising: dissolving an amount of insulin in an acidic aqueous buffer(A); adding A to liquid surfactant, the HLB value of which is between 10 and 20, with agitation to form a homogeneous solution(B); adding B to an oil, the HLB value of which is between 0 and 10, with agitation to form oil formulation. This invention has a simple process with low cost. After orally administrated, the formulation prepared with the process of the invention can resist the gastrointestinal degradation by digestive enzymes, and is easily absorbed for hypoglycemic effect.
Type:
Grant
Filed:
April 12, 2002
Date of Patent:
March 28, 2006
Assignees:
Tsinghua University, Fosse Bio-Engineering Development, Ltd.
Inventors:
Changxue Zheng, Mingxing Duan, Hong Ma, Housheng Zhong