Abstract: The invention provides a complex comprising at least one hydrophobic active agent, an ionic polymer comprising a repetitive unit of formula (I): wherein R1 represents a hydrogen atom or a straight or branched chain alkyl group, preferably a straight or branched chain alkyl group comprising from 1 to 6 carbon atoms, for example a methyl group; R2 represents a straight or branched chain alkyl group which is substituted by a group which may have a positive charge at a physiological pH wherein the ionic polymer is a homopolymer or a random copolymer, wherein the repetitive unit of formula (I) in a random copolymer comprises (dimethylamino)ethyl methacrylate, wherein the molar proportion of (dimethylamino)ethyl methacrylate repetitive units to the total number of repetitive units in a random copolymer is greater than 50%, and wherein the at least one hydrophobic active agent has a molecular weight of from 100 to 1500 g/mol; a complex for use in a method of medical treatment; a pharmaceutical composition; and a

Abstract: An acoustic sensor detects binding of a nucleic acid analyte in an impure liquid sample by measurement of the energy of the acoustic wave resulting from the binding of the nucleic acid target to the sensor surface. The analysis may be preceded by carrying out a nucleic acid amplification procedure in situ on a crude or impure biological sample and the analysis is tolerant of the presence of reagents or by-products of the amplification procedure, and also materials present from the initial biological sample.

Abstract: An acoustic sensor detects binding of a nucleic acid analyte in an impure liquid sample by measurement of the energy of the acoustic wave resulting from the binding of the nucleic acid target to the sensor surface. The analysis may be preceded by carrying out a nucleic acid amplification procedure in situ on a crude or impure biological sample and the analysis is tolerant of the presence of reagents or by-products of the amplification procedure, and also materials present from the initial biological sample.

Abstract: A sensitive assay for an analyte employing an acoustic wave sensor. A label which has a higher dissipative capacity than the analyte is adhered to the sensing surface of an acoustic wave sensor through the analyte such that the body of the label is spaced apart from and anchored to the surface of the acoustic wave sensor by a distance of 15 to 250 nm. The change in the energy losses of the acoustic wave when the label binds to the sensing surface is used to measure the presence or amount of the label. A substantial improvement in the detection limit of the label is obtained. The analyte may for example be a nucleic acid and the label may for example comprise liposomes.

Abstract: A processor-implemented method for spatial sound localization and isolation is described. The method includes segmenting, via a processor, each of a plurality of source signals detected by a plurality of sensors, into a plurality of time frames. For each time frame, the method further includes obtaining, via a processor, a plurality of direction of arrival (DOA) estimates from the plurality of sensors, discretizing an area of interest into a plurality of grid points, calculating, via the processor, DOA at each of grid points, comparing, via the processor, the DOA estimates with the computed DOAs. If the number of sources is more than 1, the method includes obtaining via the processor, a plurality of combinations of DOA estimates, from amongst the plurality of combinations, estimating, via the processor, one or more initial candidate locations corresponding to each of the combinations, selecting location of the sources from amongst the initial candidate locations.

Abstract: APPARATUSES, METHODS AND SYSTEMS FOR ESTIMATING WATER DIFFUSIVITY AND MICROCIRCULATION OF BLOOD USING DW-MRI DATA (“AEW”) are disclosed herein. The apparatuses, methods and systems provide a computational framework for choosing and applying the most appropriate model in different regions of a heterogeneous area on a voxel-by-voxel basis. The apparatuses, methods and systems also configure an intravoxel-incoherent-motion (IVIM) model for estimating water diffusivity and microcirculation of blood in the capillary network from DW-MRI low b-value data. In one implementation, the method uses a small number of b-values (at least 3 in the b-value range of 0-300 s/mm2, increasing the upper bound of the low b-value range by one b-value in the absence of DW-MRI signal at 300 s/mm2 and is able to synthetically generate DW-MRI data corresponding at higher b-values using the derived IVIM equation. The method also accounts for estimating non-Gaussian diffusion parameter Kapp.

Abstract: The ARS offers tracking, estimation of position, orientation and full articulation of the human body from marker-less visual observations obtained by a camera, for example an RGBD camera. An ARS may provide hypotheses of the 3D configuration of body parts or the entire body from a single depth frame. The ARS may also propagates estimations of the 3D configuration of body parts and the body by mapping or comparing data from the previous frame and the current frame. The ARS may further compare the estimations and the hypotheses to provide a solution for the current frame. An ARS may select, merge, refine, and/or otherwise combine data from the estimations and the hypotheses to provide a final estimation corresponding to the 3D skeletal data and may apply the final estimation data to capture parameters associated with a moving or still body.

Abstract: A processor-implemented method for regulating the flow rate of data packets in a network, including defining a global constant representing a regularly repeating time period common among flow sources in the network; transmitting current flow rate information from each of the flow sources, and for each flow, to the links traversed by each flow, exactly once during a current period; categorizing each of the flows passing through the links on the network into a category for the current period for each link by comparing the current flow rate information to a previously determined fair-share flow rate for the link; counting, in each link, the flows per category for the current period; determining a current fair-share flow rate for the current period in each link using the results of the categorizing and counting; and providing control instructions to each of the flow sources to regulate the rate of each flow.

Abstract: A storage system for organizing and maintaining metadata in a distributed network. The system includes: a network; a plurality of distributed nodes configured to communicate through the network; a plurality of block devices configured to communicate with the plurality of distributed nodes through the network; and a management server configured to communicate with each of the plurality of distributed nodes and block devices and further configured to arbitrarily associate metadata and data to any of the plurality of distributed nodes such that a global copy of the metadata does not exist in one or more fixed locations known to all distributed nodes.

Abstract: The GESTURE RECOGNITION APPARATUSES, METHODS AND SYSTEMS FOR HUMAN-MACHINE INTERACTION (“GRA”) discloses vision-based gesture recognition. GRA can be implemented in any application involving tracking, detection and/or recognition of gestures or motion in general. Disclosed methods and systems consider a gestural vocabulary of a predefined number of user specified static and/or dynamic hand gestures that are mapped with a database to convey messages. In one implementation, the disclosed systems and methods support gesture recognition by detecting and tracking body parts, such as arms, hands and fingers, and by performing spatio-temporal segmentation and recognition of the set of predefined gestures, based on data acquired by an RGBD sensor. In one implementation, a model of the hand is employed to detect hand and finger candidates.

Abstract: A method for storage input/output (I/O) path configuration in a system that includes at least one storage device in network communication with at least one computer processor; the method comprising providing in the I/O path into at least: (a) a block-based kernel-level filesystem, (b) an I/O cache module controlling an I/O cache implemented on a first computer readable medium, (c) a journaling module, and (d) a storage cache module controlling a storage cache implemented on a second computer readable medium, the second computer readable medium having a lower read/write speed than the first computer readable medium. Furthermore, the steps of translating by the filesystem, based on computer executable instructions executed by the at least one processor, a file I/O request made by an application executed by the at least one computer processor into a block I/O request and fulfilling by the at least one processor the block I/O request from one of the I/O cache and the storage cache complete the I/O operation.

Abstract: This disclosure details the implementation of apparatuses, methods and systems for audio processing and transmission. Some implementations of the system are configured to provide a method for encoding an arbitrary number of audio source signals using only a small amount of (transmitted or stored) information, while facilitating high-quality audio playback at the decoder side. Some implementations may be configured to implement, a parametric model for retaining the essential information of each source signal (side information). After the side information is extracted, the remaining information for all source signals may be summed to create a reference signal from which noise information for the original source signals may be reconstructed. The reference signal and the side information form the new collection of information to be transmitted or stored for subsequent decoding.

Abstract: A processor-implemented method for spatial sound localization and isolation is described. The method includes segmenting, via a processor, each of a plurality of source signals detected by a plurality of sensors, into a plurality of time frames. For each time frame, the method further includes obtaining, via a processor, a plurality of direction of arrival (DOA) estimates from the plurality of sensors, discretizing an area of interest into a plurality of grid points, calculating, via the processor, DOA at each of grid points, comparing, via the processor, the DOA estimates with the computed DOAs. If the number of sources is more than 1, the method includes obtaining via the processor, a plurality of combinations of DOA estimates, from amongst the plurality of combinations, estimating, via the processor, one or more initial candidate locations corresponding to each of the combinations, selecting location of the sources from amongst the initial candidate locations.

Abstract: A method for storage input/output (I/O) path configuration in a system that includes at least one storage device in network communication with at least one computer processor; the method comprising providing in the I/O path into at least: (a) a block-based kernel-level filesystem, (b) an I/O cache module controlling an I/O cache implemented on a first computer readable medium, (c) a journaling module, and (d) a storage cache module controlling a storage cache implemented on a second computer readable medium, the second computer readable medium having a lower read/write speed than the first computer readable medium. Furthermore, the steps of translating by the filesystem, based on computer executable instructions executed by the at least one processor, a file I/O request made by an application executed by the at least one computer processor into a block I/O request and fulfilling by the at least one processor the block I/O request from one of the I/O cache and the storage cache complete the I/O operation.

Abstract: Disclosed is a method of investigating the conformation of biomolecules or changes in the conformation of biomolecules as a result of an interaction, in which biomolecules from a sample of biomolecules are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, and a conformation parameter which is related to the conformation of the biomolecules from the said sample which are adhered discretely to the sensing surface, but substantially independent of the resulting change in mass loading of the sensing surface, is calculated from the resulting change in the output signals of the acoustic wave sensor. The conformation parameter may the acoustic ratio or a parameter which is directly related to the acoustic ratio.

Abstract: A method of production of photocatalytic material to be used under UV and visible light. The photocatalyst is obtained by precipitating titanium dioxide on a sol of manganese dioxide. The method includes providing a mixture of a) hydrated manganese dioxide sol, b) titanium solution and c) NH3 solution, and, the processing of the above. The photocatalyst produced with the method of the invention includes titanium and manganese with the atomic ratio Mn:Ti varying between 0.01:100 and 33:100. The manganese acts both as a dopant and as a photosensitizer. The photocatalyst is active under both UV and visible light and is able to decompose organic and inorganic pollutants. In general the photocatalyst can be used as obtained or embedded in a matrix (e.g. concrete, cement, mortar, stucco, paint etc) or immobilized on or in a solid surface/body. The photocatalyst can be further used for air or water de-pollution.

Abstract: A computer readable storage medium includes executable instructions to receive a specification of a combinational logic circuit. The specification of the combinational logic circuit is converted to a Single-Rail un-encoded circuit and a Dual-Rail encoded circuit, which periodically encodes a null value, a first valid state and a second valid state on two wires. A logic operation of the Single-Rail un-encoded circuit transpires during processing of a null value by the Dual-Rail encoded circuit.

Abstract: A computer readable storage medium includes executable instructions to construct a delay element to replicate the timing of critical gates and paths within a segment of an asynchronous circuit. The rise and fall delay mismatch of the delay element is minimized without obeying timing constraints. The position of each output of the delay element is determined to include a globally shared node within the segment and a non-shared local node in the segment.

Abstract: Disclosed is a method of investigating the conformation of biomolecules or changes in the conformation of biomolecules as a result of an interaction, in which biomolecules from a sample of biomolecules are adhered discretely to the sensing surface of an acoustic wave sensor operating in a liquid, and a conformation parameter which is related to the conformation of the biomolecules from the said sample which are adhered discretely to the sensing surface, but substantially independent of the resulting change in mass loading of the sensing surface, is calculated from the resulting change in the output signals of the acoustic wave sensor. The conformation parameter may the acoustic ratio or a parameter which is directly related to the acoustic ratio.

Abstract: A method of converting a Boolean logic circuit into an asynchronous multi-rail circuit is provided. A Boolean logic circuit is converted into a first multi-rail circuit using at least Shannon's expansion. The first multi-rail circuit is technology mapped into a second multi-rail circuit. Completion detection circuitry is added which receives the primary outputs of the second multi-rail circuit.