Abstract: Methods of treating, and for selecting a chemotherapy regimen for treatment of cancer in a patient (FIG. 9). For example, a patient genetic sample from a bilary cancer such as cholangiocarcinoma is analyzed for a mutation in ERRFII and a chemotherapeutic agent is selected as a result of the analysis. If a mutation in ERRFII is present, treatment with an inhibitor of Epidermal Growth Factor Receptor (EGFR) is shown to have inhibitory effects on tumor growth. In this manner, the chemotherapy regimen is targeted to a given mutation in a patient's cancer.
Type:
Application
Filed:
August 1, 2017
Publication date:
May 10, 2018
Applicants:
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Inventors:
Mitesh Jivraj Borad, David Craig, John Carpten
Abstract: Disclosed are a condition based preventive maintenance apparatus and method for a large operation system. The condition based preventive maintenance apparatus for a large operation system comprises: a collection part for collecting sensor data from a plurality of sensors installed in a system; a feature extraction part for wavelet-transforming the collected sensor data and extracting an energy spectrum as a feature value; a calculation part for calculating a slope and an intercept of the extracted feature value; and a monitoring part for monitoring whether the system is broken or not using the calculated slope and intercept.
Type:
Application
Filed:
January 9, 2018
Publication date:
May 10, 2018
Applicant:
Industry-University Cooperation Foundation Hanyang University
Abstract: A method for preparing a three-dimensional graphene structure, and an energy storage device are provided, the method including forming a graphene precursor by heating a carbohydrate and a gas generator, forming a graphene structure having a cavity therein by carbonizing the graphene precursor, and forming nanopores in the graphene structure, wherein the nanopores pass through an outer surface and an inner surface of the graphene structure, and are connected with the cavity.
Type:
Application
Filed:
November 3, 2017
Publication date:
May 10, 2018
Applicants:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, Gachon University of Industry-Academic Cooperation Foundation
Inventors:
Tae-Young KIM, In-Kyu YOU, Bit Na KIM, In Gyoo KIM, Sung-Hoon JUNG, Seung-Jun PARK
Abstract: Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FR?.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
May 8, 2018
Assignee:
PURDUE RESEARCH FOUNDATION
Inventors:
Philip S. Low, Dimiter S. Dimitrov, Yang Feng, Jiayin Shen
Abstract: A method for performing positioning for estimating position in a wireless communication system according to the present invention comprises transmitting, by a first UE, a positioning request message for performing the positioning to an eNB; transmitting, by the eNB, an anchor request message to neighboring UEs within a cell to find UEs which may become a second UE; receiving, the eNB, an anchor response message corresponding to a response to the anchor request message from at least one UE from among neighboring UEs within the cell; and determining, by the eNB, the second UE based on the received anchor response message.
Type:
Grant
Filed:
July 21, 2015
Date of Patent:
May 8, 2018
Assignees:
LG Electronics Inc., SNU R&DB Foundation
Inventors:
Hakseong Kim, Hanbyul Seo, Seonik Seong, Kwangbok Lee, Sunghyun Choi
Abstract: This invention describes a cell growth apparatus, particularly neuronal printed circuit board apparatus comprising an aerogel base and a pre-printed cellular growth pattern. The cellular growth pattern is comprised of combinations of layers of cellular adhesion promoting materials, cellular adhesion inhibiting materials, and/or cellular signal promoting materials. The invention further describes methods of promoting cell growth using the neuronal printed circuit board apparatus of the invention. The invention is useful for regeneration and precise guidance of cells, particularly nerve cells, when used as an implant.
Type:
Grant
Filed:
April 15, 2010
Date of Patent:
May 8, 2018
Assignee:
The University of Memphis Research Foundation
Abstract: A seamless hexagonal h-BN atomic monolayer thin film has a pseudo-single crystal structure including a plurality of h-BN grains that are seamlessly merged. Each of the h-BN grains has a dimension in a range from about 10 ?m to about 1,000 ?m. The seamless hexagonal boron nitride (h-BN) atomic monolayer thin film may be fabricated by a process including pre-annealing a metal thin film at a first temperature in a chamber while supplying hydrogen gas to the chamber; supplying nitrogen source gas and boron source gas to the chamber; and forming the seamless h-BN atomic monolayer thin film having a pseudo-single crystal atomic monolayer structure having a grain dimension in a range from about 10 ?m to about 1,000 ?m by annealing the pre-annealed metal thin film at a second temperature.
Type:
Grant
Filed:
February 8, 2016
Date of Patent:
May 8, 2018
Assignees:
SAMSUNG ELECTRONICS CO., LTD., RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
Inventors:
Hwansoo Suh, Youngjae Song, Qinke Wu, Sungjoo Lee, Minwoo Kim, Sangwoo Park
Abstract: The present invention relates to a novel gene, IbENOD93, and transgenic plants using the same. More specifically, the present invention provides an IbENOD93 gene, an open reading frame (ORF) of the IbENOD93 gene, a recombinant vector comprising the gene or the ORF, and a transformant transformed with the vector. Moreover, the present invention provides a composition for enhancing root thickening growth and promoting maturation in a plant having storage root(s). Furthermore, the present invention provides a method for producing a transgenic plant having storage root(s) with enhanced thickening growth, and a method for regulating or enhancing root thickening growth and maturation in a plant having storage root(s). According to the present invention, it is possible to promote the thickening growth of storage roots as well as the growth of aerial part.
Type:
Grant
Filed:
July 31, 2015
Date of Patent:
May 8, 2018
Assignee:
Korea University Research and Business Foundation
Abstract: A condensed cyclic compound is represented by Formula 1. An organic light-emitting device includes the condensed cyclic compound represented by Formula 1. X, Y1, Y2, A, B, and R1 of Formula 1 are described herein. An organic light-emitting device including an organic layer including the condensed cyclic compound may have low driving voltage, high efficiency, high brightness, and long lifespan.
Type:
Grant
Filed:
July 22, 2014
Date of Patent:
May 8, 2018
Assignees:
Samsung Display Co., Ltd., Pusan National University Industry-University Cooperation Foundation
Inventors:
Jae-Hong Kim, Myeong-Suk Kim, Sung-Wook Kim, Jin-Soo Hwang, Hong-Suk Suh
Abstract: A vehicle system includes a plurality of capacitors each forming a portion of a vehicle structure, and a parallel electrical link between a pair of the plurality of capacitors, such that the pair of capacitors act as an aggregate capacitor.
Type:
Grant
Filed:
August 12, 2014
Date of Patent:
May 8, 2018
Assignees:
University of North Dakota, NDSU Research Foundation
Abstract: The present invention relates to a Krueppel-like factor 10 (KLF10) gene expression inhibitor promoting cartilage differentiation, and more specifically, to: a composition for promoting chondrocyte differentiation or treating cartilage diseases, containing a KLF10 gene expression inhibitor promoting cartilage differentiation and inhibiting the hypertrophy and dedifferentiation of chondrocytes; a cell therapeutic agent containing the composition; a method for promoting cartilage differentiation in bone marrow stem cells, comprising a step of expressing the composition in bone marrow stem cells; and a method for screening a chondrocyte differentiation promoter or a chondrocyte therapeutic agent.
Type:
Grant
Filed:
December 30, 2014
Date of Patent:
May 8, 2018
Assignee:
DONGGUK UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION
Abstract: A computing device may include a display, a memory to store electronic textbook data comprising at least one configurable problem to be solved for a system having a plurality of different parameters, a user input device, and a processor coupled to the display, the memory, and the user input device. The processor may be configured to display the electronic textbook data with the at least one configurable problem on the display, selectively change at least one of the parameters of the system to define a new solution for the at least one configurable problem based upon the user input device, and display the new solution on the display.
Type:
Grant
Filed:
October 5, 2015
Date of Patent:
May 8, 2018
Assignee:
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
Inventors:
Issa Batarseh, Ghaith Haddad, Rashad Oreifej, Rawad Al-Haddad
Abstract: A fusion peptides with sequences derived from the extracellular domain of syndecan-1 that inhibits VLA-4 and IGF-1R signaling are disclosed. The fusion peptides include an IGF-1R-binding segment having the amino acid sequence LPAGEGPKEGEAVVLPEVEPGLTAREQ (SEQ ID NO:1) and a VLA-4-binding segment having the amino acid sequence sequence DFTFETSGENTA (SEQ ID NO:2).
Type:
Grant
Filed:
August 18, 2017
Date of Patent:
May 8, 2018
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Alan C. Rapraeger, DeannaLee M. Beauvais, Oisun Jung
Abstract: Various embodiments of the present invention include assemblies and methods for utilizing antennas with high gain in small satellites. In one embodiment, a satellite comprising a payload configured for transmitting data is provided. The payload may include various components of the satellite, such as the attitude control system, electrical power system, and/or communication system. The satellite may be configured to communicate with one or more ground stations. The satellite includes a support structure comprising at least one deployable panel, wherein the support structure houses the payload. The satellite also includes at least one antenna coupled to the support structure, wherein the deployable panel is configured to cover the antenna in a non-deployed state and to expose the antenna in a deployed state.
Type:
Grant
Filed:
June 11, 2013
Date of Patent:
May 8, 2018
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Norman G. Fitz-Coy, Vivek Shirvante, Shawn Johnson, Kathryn Cason
Abstract: Embodiments of the invention provide methods and devices for improved drainage systems and tubing. In one embodiment, a context-sensitive flow interrupter is provided that inhibits or facilitates flow of fluid when engaged with a mating holder. In another embodiment, outflow is optimized through control of the pressure in gas pockets in a tube, drainage tube or assembly. In one such embodiment, gas pockets are vented to inhibit excessive back-pressure or suction on an organ, vessel or cavity being drained. In another such embodiment, loops in the tubes are avoided by using a mechanical template in the form of a groove or peg assembly to thread the slack in the drainage tube to generate a monotonic gradient. In another embodiment, such as for active drainage systems, a bypass channel is provided that allows an applied vacuum to go around an obstruction created by the collection of fluid in an undrained dependent loop.
Type:
Grant
Filed:
September 8, 2011
Date of Patent:
May 8, 2018
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Samsun Lampotang, Nikolaus Gravenstein, Wilhelm K. Schwab, David E. Lizdas, Francesca K. Enneking
Abstract: A ray tracing core includes a ray generation unit and a plurality of T&I (Traversal & Intersection) units with MIMD (Multiple Instruction stream Multiple Data stream) architecture. The ray generation unit generates at least one eye ray based on an eye ray generation information. The eye ray generation information includes a screen coordinate value. Each of the plurality of T&I units receives the at least one eye ray and checks whether there exists a triangle intersected with the received at least one eye ray. The triangle configures a space.
Type:
Grant
Filed:
March 23, 2016
Date of Patent:
May 8, 2018
Assignees:
SILICONARTS, INC., INDUSTRY-ACADEMIA COOPERATION FOUNDATION OF SEJONG UNIVERSITY
Abstract: Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and a uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid.
Type:
Grant
Filed:
July 6, 2012
Date of Patent:
May 8, 2018
Assignee:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
Inventors:
James F. Klausner, Renwei Mei, Ayyoub Mehdizadeh Momen, Kyle Allen
Abstract: An implantable pressure sensor arrangement is disclosed. The arrangement includes a substrate, a coil positioned on the substrate, a flexible membrane positioned proximate to the coil and configured to be moveable with respect to the coil, thereby forming a fluid chamber, fluidly sealed from outside of the implantable pressure sensor arrangement, a porous membrane positioned on the flexible membrane and configured to transfer pressure from outside of the implantable pressure sensor arrangement onto the flexible membrane wherein a differential pressure is generated on the two sides of the flexible membrane thereby causing the flexible membrane to deflect towards and away from the coil, and an electrode coupled to the flexible membrane.
Type:
Grant
Filed:
June 16, 2014
Date of Patent:
May 8, 2018
Assignee:
PURDUE RESEARCH FOUNDATION
Inventors:
Babak Ziaie, Marcus Anthony Brown, Teimour Maleki-Jafarabadi, Seung Hyun Song
Abstract: The present invention relates to a use of a human small leucine zipper protein in the osteogenesis procedure. More specifically, sLZIP increases the transcriptional activity of Runx2 and inhibits the transcriptional activity of PPAR?2, thereby increasing the osteoblast differentiation, so that sLZIP performs an important role in the osteogenesis procedure, and thus can be used as a marker for treating bone disease and developing new medicines.
Type:
Grant
Filed:
April 30, 2014
Date of Patent:
May 8, 2018
Assignee:
Korea University Research and Business Foundation
Abstract: An isothiocyanate functional surfactant, wherein the protonated form of said surfactant is represented by the following chemical structure: wherein X includes an integer ranging from approximately 1 to approximately 25, and wherein Y includes an integer ranging from approximately 6 to approximately 25.