Abstract: Mutual prodrugs of glucosamine, and derivatives and analogs of glucosamine and an anti-inflammatory agent, compositions thereof, and methods for, e.g., treating disorders and conditions by administration of the compositions are provided. Topical compositions of glucosamine, and derivatives and analogs of glucosamine are also provided.

Abstract: Vitamin E succinate derivatives according to formula I: are described. These compounds can be included in pharmaceutical compositions, and can be used for the treatment of cancers such as metastatic cancer and as antiadhesive agents.

Abstract: The present invention is to provide means to treat breast cancer and/or mastitis by topically administering a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent and allowing them efficiently to arrive into the mammary gland. The present invention provides an iontophoretic preparation for treating breast cancer and/or mastitis which contains a non-steroidal antiinflammatory analgetic agent and/or an anticancer agent as an active ingredient and has a donor to be applied on a nipple part for topical administration of the active ingredient from the nipple part to the mammary gland by application of electric potential.

Abstract: An apparatus and method is related to providing sensing functions that are similar to “human touch” when located in a prosthetic device such as a BION microstimulator that is implanted in a patient. The apparatus includes a power circuit, a communication circuit, and a sensor circuit. The power circuit provides power to the communication circuit and the sensor circuit. The sensor cooperates with the communication circuit, which communicates to the brain. The sensor uses various techniques to detect changes in the environment for the surrounding tissue using criteria such as reflectivity, impedance, conductivity, return signal spectrum, return signal rate, and return signal phase to name a few. For example, the impedance observed by the sensor changes when: the skin tissue is deformed around the sensor, or when the skin is surrounded by water. The sensory information is interpreted by the brain as an analog of touch or feel.

Abstract: Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

Abstract: Examples of the present invention include methods of assembling structures, such as nanostructures, at predetermined locations on a substrate. A voltage between spaced-apart electrodes supported by substrate attracts the structures to the substrate, and positional registration can be provided the substrate using topographic features such as wells. Examples of the present invention also include devices, such as electronic and optoelectronic devices, prepared by such methods.

Abstract: Disclosed herein is a method for increasing the production of crops, particularly wheat and soybean, using herbicide resistant cultivars. In one aspect of this method, the method increases crop yield by diminishing the impact of the root diseases caused by Gaeumannomyces and Rhizoctonia species by treating the crop with an herbicide, in particular glyphosate. In another aspect the method for treating crops reduces the effects foliar pathogens and diseases, particularly fungal pathogens, such as rusts, including soybean rust, stem rust, stripe rust and leaf rust.

Abstract: Endocytosis of an active agent into a cell having surface receptors can be enhanced by using particles that have a radius no less than an endocytotic threshold determined based on a surface density of the receptors, a surface density of the moieties and interaction parameters that include at least one of a receptor-moiety spring constant and a non-specific interaction strength.

Abstract: The invention relates to methods for making a peptide standard for mass spectrometry said method comprising (a) identifying endopeptidase cleavage sites in a parent polypeptide sequence of interest; (b) selecting peptide sequences from said parent polypeptide which are defined by endopeptidase cleavage sites of step (a); (c) adding a C-terminal extension to each selected sequence; wherein if the endopeptidase cleavage site is C-terminal to its recognition sequence then the C-terminal extension comprises 1 to 6 amino acids, wherein if the endopeptidase cleavage site is N-terminal to its recognition sequence then the C-terminal extension comprises said recognition sequence, wherein if the endopeptidase cleavage site is within its recognition sequence then the C-terminal extension comprises the remainder of said recognition sequence C-terminal to the cleavage site; and (d) synthesizing a peptide having the extended amino acid sequence of step (c).

Abstract: Disclosed are compositions and methods for reducing the proliferation of ALL cancer cells through targeted interactions with ALL1 fusion proteins.

Abstract: Provided are a TDC having a pipeline or cyclic structure and an operating method thereof. The TDC includes a first stage block and a second stage block. The first stage block detects a first bit of a digital code for a time difference between first and second input signals. The second stage block detects a second bit of the digital code for a time difference between first and second output signals of the first stage block. The first stage block amplifies a time difference between first and second delay signals for the first and second input signals to generate the first and second output signals, and transfers the first and second output signals to the second stage block.

Abstract: A non-contact, passive method for measurement of arterial pulse from areas such as the major superficial arteries of the body through analysis of thermal IR images acquired by passive thermal IR imaging sensors, and through the modeling of the pulsatile nature of the blood flow and arterial pulse propagation in the circulatory system. The method is automatic and does not need operator input. The output waveform readily contains the information on heart rate, cardiac interbeat intervals, heart-rate variability and other features inherent in arterial pulse.

Abstract: A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.

Abstract: A spelling correction system and method automatically recognizes and corrects misspelled inputs in an electronic device with relatively lower computing power. In a learning process, a misspelling correction dictionary is constructed on the basis of a corpus of accepted words, and context-sensitive strings are selected from among all the strings registered in the dictionary. Context information about the context-sensitive strings is acquired. In an applying process, at least one target string is selected from among all the strings in a user's input sentence through the dictionary. If the target string is one of the context-sensitive strings, the target string is corrected by use of the context information.

Abstract: A cubic epitaxial article and electronic devices therefrom includes a single crystal cubic oxide substrate having a substrate band gap and a top surface. An epitaxial cubic oxide alloy layer that includes at least one transition metal or group IIA metal disposed on the top surface of the substrate. The epitaxial cubic oxide alloy layer has a band gap that is different than the substrate band gap and has a lattice that is lattice matched within 5% to a lattice of the single crystal cubic oxide substrate.

Abstract: The subject invention concerns materials and methods for providing plants or plant tissue with increased starch biosynthesis. Increased starch biosynthesis provides for increased yield. One aspect of the invention concerns polynucleotides that encode a mutant plant large subunit of AGPase. In one embodiment, a polynucleotide of the invention encodes a plant AGPase large subunit having an amino acid mutation wherein the cysteine amino acid corresponding to amino acid position 424 of wild type maize AGPase large subunit is substituted with an amino acid that results in increased AGPase activity when provided in an AGPase enzyme. In a specific embodiment, the cysteine corresponding to amino acid position 424 of wild type maize AGPase large subunit is substituted with a valine amino acid. The subject invention also comprises a mutant plant large subunit of AGPase encoded by a polynucleotide of the invention.

Abstract: The invention herein generally relates to non-destructive, high order harmonic ion motion image current detection. In certain embodiments, ion motion corresponding to high order harmonic frequencies, instead of the secular frequencies, is detected using image current detection with a constant excitation applied to the waveform signal.

Abstract: Disclosed are an apparatus and method of determining an optimal cyclic delay value. The method of determining the optimal cyclic delay value includes determining a Signal-to-Interference and Noise Ratio (SINR) function depending on a diversity order; determining a channel estimation error variance function; and determining an SINR being required for a system according to the SINR function and the channel estimation error variance function.

Abstract: The timing cycles in a circuit design are identified and cut such that timing constraint paths in the circuit design are preserved. Timing cycles in the circuit design may be identified by traversing an adjacency list data structure, in which elements of the circuit design are represented as vertices interconnected by edges. Timing constraint paths may be distinguished from false timing paths using timing analysis, such as a greatest common path heuristic. Timing constraint paths may be marked as “constrained” to prevent these paths from being cut. With the cycles and timing constraint paths identified, cuts may be selected that cut the identified timing cycles while preserving the timing constraint paths. The cycle cuts allow the circuit design to be correctly processed within a conventional CAD tool design flow.

Abstract: The present system and method provides a more precise way to record food and beverage intake than traditional methods. The present disclosure provides custom software for use in mobile computing devices that include a digital camera. Photos captured by mobile digital devices are analyzed with image processing and comparisons to certain databases to allow a user to discretely record foods eaten. Specifically, the user captures images of the meal or snack before and after eating. The foods pictured are identified. Image processing software may identify the food or provide choices for the user. Once a food is identified and volume of the food is estimated, nutrient databases are used for calculating final portion sizes and nutrient totals.