Abstract: Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent.

Abstract: This invention relates to a sensor for detecting a stem cell differentiation, including (a) an electrode; and (b) a substrate of an alkaline phosphatase. The phosphorylation or dephosphorylation of the substrate for an alkaline phosphatase as a stem cell undifferentiation marker which dephosphorylates its substrate may be measured using an electrical signal in the present sensor. Therefore, the sensor of the present invention enables to electrically detect a stem cell status in a high-throughput manner and to determine the stem cell differentiation.

Abstract: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.

Abstract: Provided are an antenna apparatus for linearly polarized diversity antennas in a radio frequency identification (RFID) reader, and a method of controlling the antenna apparatus. The antenna apparatus includes: a plurality of linearly polarized diversity antennas disposed to have different directions to one another; a switching unit connecting the linearly polarized diversity antennas to the RFID reader; and a controller controlling the switching unit to selectively activate the linearly polarized diversity antennas.

Abstract: The present invention relates to methods of inducing neuronal production in the brain, recruiting neurons to the brain, and treating a neurodegenerative condition by providing a nucleic acid construct encoding a neurotrophic factor, and injecting the nucleic acid construct intraventricularly into a subject's brain.

Abstract: The disclosure relates to recombinant adult human apohemoglobin (apo-rHb) in which the stability has been increased by replacement of an amino acid with a counterpart from another organism, such as a deep sea diving mammal. This mutated apo-rHb may be more stable and/or give higher production yields than unmutated adult human apo-rHb. The mutated apo-rHb may be produced in microorganisms, such as E. coli or yeast cells, or animal erythroid cells. Some apo-rHb of the present disclosure may be used as part of a blood substitute.

Abstract: An isolated multipotent neural stem cells has a phenotype identified by expression of the protein ?-tubulin IV and Olig2 and the absence of the proteins NG2, PLP, and GFAP.

Abstract: The present invention relates to targets, systems and methods for the cyclotron production of 124I from aluminum telluride (Al2Te3) targets. The systems and methods utilize low energy proton cyclotrons to produce 124I by the 124Te(p,n) reaction from enriched Al2Te3 glassy melts. The 124I is recovered in high yield from the glassy melt by adapted methods of common thermal distillation techniques.

Abstract: The present invention relates to compositions and methods for controlling nematode infestation of plants. In particular, the present invention provides vectors comprising sequences designed to control nematodes by RNA interference (RNAi) and transgenic plants transformed with such vectors.

Abstract: The present invention provides metal silicide nanowires, including metallic, semiconducting, and ferromagnetic semiconducting transition metal silicide nanowires. The nanowires are grown using either chemical vapor deposition (CVD) or chemical vapor transport (CVT) on silicon substrates covered with a thin silicon oxide film, the oxide film desirably having a thickness of no greater than about 5 nm and, desirably, no more than about 2 nm (e.g., about 1-2 nm). The metal silicide nanowires and heterostructures made from the nanowires are well-suited for use in CMOS compatible wire-like electronic, photonic, and spintronic devices.

Abstract: A method for enhancing underwater imaging affected by image degradation effects, the method comprising: acquiring at least one image of an underwater scene using an imaging device; determining information regarding distances of parts of the scene relative to the imaging device; and reconstructing an image of the underwater scene using a physics-based mathematical model, compensating image characteristics influenced by distance-dependent underwater degradation effects including veiling light, using the information on the distances of parts of the scene from the imaging device, and compensating distance-dependent underwater degradation effects relating to the distance of illumination sources from the scene.

Abstract: Method and system that provides, among other things, the capability for using hyperpolarized xenon-129 as a probe to non-invasively and non-destructively characterize important properties of certain structures or materials into which hyperpolarized xenon-129 can be introduced and wherein the xenon exists in two or more chemically-shifted states that are in exchange High-resolution MR images can be generated in a fraction of a second wherein the associated signal intensities reflect material properties that characterize the gas exchange among the different states. For example, in the human or animal lung, the system and related method can exploit the differences in gas-exchange characteristics between healthy and diseased lung tissue to generate high-resolution, high signal-to-noise cross-sectional MR images that permit non-invasive regional detection of variations in lung tissue structure with a combination of spatial and temporal resolution that is unmatched by any current imaging modality.

Abstract: Methods and systems are disclosed for signal processing. A method includes receiving a plurality of digitized coefficients determining a best-fit distribution of a general family of distributions for the plurality of digitized coefficients, and providing a characterization of the digitized coefficients based upon the determined best-fit distribution. The system includes a memory for storing computer program instructions and a processor in communication with the memory. The processor is operable to execute the computer program instructions to receive a plurality of digitized coefficients, determine a best-fit distribution of a general family of distributions for the plurality of digitized coefficients, and provide a characterization of the digitized coefficients based upon the determined best-fit distribution.

Abstract: The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to molecular and biomolecular sensing methods based on analyte recognition by carbodithioate ligands bonded to surfaces.

Abstract: Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.

Abstract: A micropump including one or more microchannels for receiving a fluid and a plurality of electrodes arranged on a diaphragm and energized in a manner to provide an enhanced electrohydrodynamic flow of fluid through the one or more microchannels. The micropump may be used for pumping a working fluid for removing heat from a heat-generating electronic component or for delivery of a drug, medicine, or other treatment agent as or in a fluid to a patient.

Abstract: The present invention provides methods and systems for evaluating biological materials for the diagnosis of disease, such as gland abnormalities, and the cancerous and precancerous conditions. Nonlinear optical microscopy techniques, such as MP microscopy and harmonic generation microscopy, are used to generate high resolution, three dimensional images of a test tissue, such as a biopsy tissue sample and tissue in whole organisms, that are analyzed, optionally in combination, to detect, identify and characterize tumor-associated collagen signatures. The presence, abundance and extent of histological features and structural motifs comprising tumor-associated collagen signatures may be directly and accurately correlated with the onset and progression of cancer, such as breast cancer. The present methods are capable of providing an accurate and selective diagnosis of cancer, and provide diagnostic information complementary to conventional diagnostic methods.

Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.

Abstract: A preparatory pulse sequence is applied prior to an imaging pulse sequence during a diffusion-weighted MRI scan. The preparatory pulse sequence diffusion weights the longitudinal magnetization using a gradient waveform that is first moment nulled to reduce image artifacts caused by patient motion.

Abstract: A new and distinct variety of strawberry (Fragaria×ananassa), which originated from seed produced by a hand-pollinated cross between FL 96-114 and FL 95-200. The new strawberry, named ‘Florida Elyana’, is distinguished by production of large, firm, exceptionally flavored fruit and resistance to crown and fruit rots when grown in west central Florida or other areas that have a subtropical climate similar to that of west central Florida.