Abstract: The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof.
Type:
Application
Filed:
June 18, 2009
Publication date:
February 18, 2010
Applicant:
University of Georgia Research Foundation, Inc.
Abstract: Techniques for positioning the nano-materials onto one or more targets are provided. In some embodiments, a device for positioning the nano-materials onto one or more targets may comprise a delivery line for delivering a gas from a gas supply, an applicator coupled to the delivery line and having a tip for ejecting the gas, the tip being adjustable so as to be oriented at a predetermined ejection angle with respect to said one or more targets, and an actuator coupled to the applicator for driving the applicator to move over said one or more targets and change the orientation of the tip.
Abstract: This application relates to the functional identification and characterization of a nucleic acid molecule encoding a triterpene synthase, in particular botryococcene synthase. Also described are host cells comprising the nucleic acid molecules of this invention, proteins encoded by the nucleic acid molecules and methods for using the nucleic acid molecules, transformed hosts and encoded proteins to produce high levels of triterpene hydrocarbons.
Type:
Application
Filed:
August 11, 2009
Publication date:
February 18, 2010
Applicant:
University of Kentucky Research Foundation
Inventors:
Joe CHAPPELL, Shigeru Okada, Tom Niehaus, Tim Devarenne
Abstract: Provided are a method and apparatus for processing an image. The method includes receiving a first luminance image of an image including airlight, which is a type of light that occurs in a foggy environment, and generating an airtight map based on a ratio between an average luminance of the first luminance image, and a standard deviation; and removing the airtight by subtracting the airtight map from the first luminance image and outputting a second luminance image. According to the present invention, airlight components may be effectively removed.
Type:
Application
Filed:
May 7, 2009
Publication date:
February 18, 2010
Applicants:
Samsung Techwin Co., Ltd., Korea University Industrial & Academic Collaboration Foundation
Inventors:
Bong-hyup Kang, Dong-jun Kim, Chang-won Jeon, Hanseok Ko
Abstract: The present invention provides methods and compositions for modulating proliferation, differentiation, migration, and adhesion of cardiovascular cell types.
Abstract: The present invention provides photosensitizing agents obtained by reducing a single double bond in the porphyrin macrocycle of a sulphonated meso-tetraphenylporphyrin, preferably a disulphonated meso-tetraphenylporphyrin such as TPPS2a. The resulting sulphonated meso-tetraphenyl chlorins include compounds of formula (I) (wherein X is —SO3H; n, p, q and r are each independently 0 or 1; and the sum of n, p, q and r is an integer from 1 to 4, preferably at least 2, e.g. 2 or 4) isomers and isomer mixtures thereof. The compounds of the invention and their pharmaceutically acceptable salts find particular use as photosensitizing agents in the photochemical internalization of molecules and in photodynamic therapy.
Type:
Grant
Filed:
August 30, 2002
Date of Patent:
February 16, 2010
Assignee:
The Norwegian Radium Hospital Research Foundation
Inventors:
Claude Rimington, Greta Rimington, legal representative, Kristian Berg, Diem Thuy Thi Tran, Pal Kristian Selbo
Abstract: The invention provides methods and materials for determining a prognosis for myeloma and myeloma-disposed patients. The methods include the use of FISH techniques. The identification of the chromosomal abnormalities t(4;14)(p16;q32), t(14;16)(q32;q23), or 17p13 deletion (p53) in plasma cells from a patient indicates a poor prognosis.
Type:
Grant
Filed:
November 10, 2003
Date of Patent:
February 16, 2010
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation, methods for assessing eosinophil degranulation, and methods for identifying inhibitors of fungus-induced inflammation and/or eosinophil degranulation are provided.
Type:
Grant
Filed:
October 13, 2006
Date of Patent:
February 16, 2010
Assignees:
Mayo Foundation for Medical Education and Research, Virginia Tech Intellectual Properties, Inc.
Inventors:
Hirohito Kita, Jens Ponikau, Christopher Lawrence
Abstract: A Doherty power amplifying apparatus includes a harmonic-controlled Doherty amplifier; and an input matching unit and an output matching unit for input matching and output matching the harmonic-controlled Doherty amplifier, respectively. The harmonic-controlled Doherty amplifier includes a carrier amplifier; a peaking amplifier arranged in parallel to the carrier amplifier; and a harmonic control circuit, arranged in front of the output matching unit, for controlling a harmonic component of an output of the Doherty amplifier to enable the Doherty amplifier to perform a switching or saturation operation.
Type:
Grant
Filed:
February 11, 2008
Date of Patent:
February 16, 2010
Assignee:
Postech Academy-Industry Foundation
Inventors:
Bumman Kim, Jangheon Kim, Young yun Woo, Junghwan Moon
Abstract: Detection apparatus for use in the detection of the presence of a selected pathogen in a sample are disclosed. Such apparatus include: a substrate with a detection region on a surface thereof, the detection region having microstructures including grooves formed therein that will align liquid crystal material in contact therewith, the width and depth of the grooves being in the range of 10 ?m or less; a blocking layer on the surface of the detection region of the substrate that does not disrupt the alignment of liquid crystal material in contact therewith, the blocking layer blocking nonspecific adsorption of pathogens to the surface; and a binding agent on the surface of the detection region of the substrate, the binding agent specifically binding the selected pathogen.
Abstract: Aspects of the present invention also provide methods based on novel UCN3 nucleotide polymorphisms selected from the group consisting of AAFC03043460.1:g.8272-8281AATAATAAAT(SEQ ID NO: 9)>GGAGC, g.8208C>T, g.8265C>T, g.8287T>C, g.8412A>G, g.8426T>A, c.8786C>T, g.9074T>C, c.12609C>T, c.12621T>C, c.12667T>G and c.12669C>A , which may provide novel markers for marbling and/or subcutaneous fat. Additional aspects provide for novel methods which may comprise marker-assisted selection or marker-assisted management to improve marbling and/or subcutaneous fat depth in cattle.
Type:
Grant
Filed:
November 15, 2007
Date of Patent:
February 16, 2010
Assignee:
Washington State University Research Foundation
Inventors:
Zhihua Jiang, Jennifer J. Michal, Galen A. Williams
Abstract: A class of 2?-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer.
Type:
Grant
Filed:
November 19, 2007
Date of Patent:
February 16, 2010
Assignees:
Emory University, The University of Georgia Research Foundation, Inc.
Inventors:
Raymond F. Schinazi, Dennis C. Liotta, Chung K. Chu, J. Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H. Hong
Abstract: Disclosed herein is a method of making a film, the method comprising depositing a first layer polyelectrolyte on a surface of a substrate to form a first layer; and depositing a second layer polyelectrolyte on the first layer polyelectrolyte to form a second layer. The first layer polyelectrolyte, the second layer polyelectrolyte, or both, is deposited on the substrate in the presence of a polymeric precipitant; and the first layer polyelectrolyte and the second layer polyelectrolyte have net charges of opposite polarity. Also disclosed are methods of improving bioactive molecule retention during fabrication of a polyelectrolyte multilayer film.
Type:
Grant
Filed:
November 13, 2006
Date of Patent:
February 16, 2010
Assignee:
Louisiana Tech University Research Foundation
Abstract: An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation.
Type:
Grant
Filed:
October 29, 2002
Date of Patent:
February 16, 2010
Assignee:
Colorado State University Research Foundation
Inventors:
Susan P. James, Min Zhang, Guy Beauregard
Abstract: Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides according to formulae (I) and (II) are disclosed where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
Type:
Grant
Filed:
July 19, 2006
Date of Patent:
February 16, 2010
Assignees:
Ohio State Univesity Research Foundation, The University of Tennessee Research Foundation
Inventors:
Duane D. Miller, James T. Dalton, Veeresa Gududuru, Eunju Hurh
Abstract: The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction.
Type:
Grant
Filed:
December 6, 2004
Date of Patent:
February 16, 2010
Assignees:
The Research Foundation of State University of New York, Roswell Park Cancer Institute
Inventors:
David G. Hangauer, Tao Ji, Madison Lee, Steven Pruitt
Abstract: High aspect ratio micromachined structures in semiconductors are used to improve power density in Betavoltaic cells by providing large surface areas in a small volume. A radioactive beta-emitting material may be placed within gaps between the structures to provide fuel for a cell. The pillars may be formed of SiC. In one embodiment, SiC pillars are formed of n-type SiC. P type dopant, such as boron is obtained by annealing a borosilicate glass boron source formed on the SiC. The glass is then removed. In further embodiments, a dopant may be implanted, coated by glass, and then annealed. The doping results in shallow planar junctions in SiC.
Type:
Grant
Filed:
August 24, 2006
Date of Patent:
February 16, 2010
Assignee:
Cornell Research Foundation, Inc.
Inventors:
M V S Chandrashekhar, Christopher Ian Thomas, Michael G. Spencer
Abstract: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine gene encoding mitochondrial transcription factor A (“TFAM”) and their associations with economically relevant traits in beef production. The invention further encompasses methods and systems, including network-based processes, to manage the SNP data and other data relating to specific animals and herds of animals, veterinarian care, diagnostic and quality control data and management of livestock which, based on genotyping, have predictable meat quality traits, husbandry conditions, animal welfare, food safety information, audit of existing processes and data from field locations.
Type:
Grant
Filed:
May 26, 2006
Date of Patent:
February 16, 2010
Assignee:
Washington State University Research Foundation
Abstract: A method for designing a metal ion for use in a molecular dynamics simulation can include the steps of building a metal ion molecule having a center atom and a dummy atom, assigning a van der Waals radius to the center atom, and assigning a charge to the dummy atom. A metal ion molecule may have the center atom covalently linked to one or more dummy atoms resulting in the metal ion molecule having a polyhedron geometry. New force field parameters may be used in methods for designing metal ions for use in molecular dynamics simulations.
Type:
Grant
Filed:
November 26, 2003
Date of Patent:
February 16, 2010
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: Antibodies to heavy chain of human FcRn are provided which function as non-competitive inhibitors of IgG binding to FcRn. The antibodies may be polyclonal, monoclonal, chimeric or humanized, or antigen binding fragments thereof. These antibodies are useful for reducing the concentration of pathogenic IgGs in individuals and therefore used as a therapeutic tool in autoimmune and alloimmune conditions.
Type:
Grant
Filed:
December 6, 2006
Date of Patent:
February 16, 2010
Assignee:
The Research Foundation of State University of New York
Inventors:
Joseph P. Balthasar, Ryan J. Hansen, Feng Jin