Patents Assigned to Foundation
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Patent number: 7135143Abstract: A device for detecting a compound in a sample includes a substrate and a self-assembled monolayer. The substrate includes a support with a metallized top surface, and the self-assembled monolayer includes an alkanethiol attached to the metallized top surface of the substrate and having a functional group that reversibly or irreversibly interacts with the compound. A liquid crystal is disposed on the self-assembled monolayer opposite the side of the self-assembled monolayer attached to the metallized top surface of the substrate. The liquid crystal includes a moiety that interacts with the functional group of the alkanethiol. When the compound is present in a sample that that contacts the self-assembled monolayer, the orientation of the liquid crystal is altered.Type: GrantFiled: August 16, 2001Date of Patent: November 14, 2006Assignee: Wisconsin Alumni Research FoundationInventors: Nicholas L. Abbott, Rahul R. Shah
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Patent number: 7136696Abstract: Electrical signal data from a target location are recorded and collected. A signal analyzer analyzes the signal data and determines whether characteristics of the signal data resemble noise data or whether a departure from noise is present. If the characteristics show a departure from noise, neuronal activity at the target location is indicated.Type: GrantFiled: May 3, 2002Date of Patent: November 14, 2006Assignee: The Cleveland Clinic FoundationInventor: Erwin B. Montgomery, Jr.
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Patent number: 7136704Abstract: An oxygen monitoring system measures the oxygen concentration in a patient's blood for use as a physiological control parameter in rate responsive pacing. The oxygen monitoring system includes an oxygen monitoring circuit embedded in a cardiac stimulation lead and monitors the blood oxygen in a patient's venous system that passes through and into the lead. The oxygen monitoring circuit includes a working electrode, a counter electrode, a reference electrode and an IC chip electrically interconnected between the electrodes and programmed to carry out an oxygen concentration measuring process. Oxygen surrounding the electrodes causes current to flow between the electrodes and the IC chip varies the value of current generated by a current source coupled between the working electrode and counter electrode in a manner to maintain the voltage between the working electrode and reference electrode at a preselected value. The variation of the current source value is a direct measure of the blood oxygen concentration.Type: GrantFiled: April 16, 2003Date of Patent: November 14, 2006Assignee: Alfred E. Mann Foundation for Scientific ResearchInventor: Joseph H. Schulman
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Patent number: 7134435Abstract: Described are sleeping apparatus and related methods that involve a motion-limiting member, a therapeutic device, or both, positioned at the lumbar spine.Type: GrantFiled: October 22, 2003Date of Patent: November 14, 2006Assignee: Mayo Foundation for Medical Education and ResearchInventor: Ruel W. Scott
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Patent number: 7135697Abstract: A semiconductor quantum dot device converts spin information to charge information utilizing an elongated quantum dot having an asymmetric confining potential along its length so that charge movement occurs during orbital excitation. A single electron sensitive electrometer is utilized to detect the charge movement. Initialization and readout can be carried out rapidly utilizing RF fields at appropriate frequencies.Type: GrantFiled: February 25, 2004Date of Patent: November 14, 2006Assignee: Wisconsin Alumni Research FoundationInventors: Mark Gregory Friesen, Charles George Tahan, Robert James Joynt, Mark A. Eriksson
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Patent number: 7135173Abstract: The present invention provides methods and compositions for eliminating virally-infected cells by administering a Shiga-toxin composition, and the present invention provides methods and compositions for suppressing bovine leukemia-related cell proliferation. In the methods, a Shiga-toxin composition is administered in an amount effective to suppress bovine leukemia-related cell proliferation. The Shiga-toxin composition can include a Shiga-toxin polypeptide; a probiotic microorganism expressing a Shiga-toxin polypeptide; or a transgenic plant expressing a Shiga-toxin polypeptide. In one embodiment, the Shiga-toxin polypeptide is Stx1A and, in another embodiment, the Shiga-toxin polypeptide is Stx1 holotoxin. In yet a further embodiment, the Shiga-toxin polypeptide comprises Stx2.Type: GrantFiled: December 18, 2002Date of Patent: November 14, 2006Assignee: Idaho Research Foundation, Inc.Inventors: Carolyn H. Bohach, Witold A. Ferens
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Patent number: 7135917Abstract: A left-handed nonlinear transmission line system has multiple nonlinear capacitors connected in series between input and output terminals and multiple inductances connected in parallel between the nonlinear capacitors and a return conductor extending between the input and output terminals. The nonlinear capacitors have a capacitance characteristic that changes with the voltage applied across the capacitors, such as a capacitance that decreases with increasing voltage. A radio frequency signal source is coupled to the input terminals and provides power at a selected drive frequency. Depending on the frequency of the drive signal with respect to the Bragg cutoff frequency of the nonlinear transmission line, the output signal may include a strong signal component at the third harmonic of the input drive signal frequency, components at higher harmonics, or components at fractional frequencies of the input drive signal frequency.Type: GrantFiled: June 3, 2004Date of Patent: November 14, 2006Assignee: Wisconsin Alumni Research FoundationInventors: Alexander B. Kozyrev, Daniel W. van der Weide
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Patent number: 7134597Abstract: A voting system that allows voters who may be blind or otherwise disabled to use election ballots without needing to see the ballot. The present invention provides a balloting system which presents and holds an election ballot while allowing a voter to cast and inspect votes. The system provides audible or tactile feedback when voting targets are probed with a wand or other pointing means. The feedback can comprise information pertaining to a candidate at a position on the ballot. The feedback can also comprise information pertaining to a mark that may or may not have been made on the ballot.Type: GrantFiled: August 23, 2002Date of Patent: November 14, 2006Assignee: University of Iowa Research FoundationInventor: Douglas W. Jones
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Publication number: 20060251298Abstract: Apparatus for obtaining 3-Dimensional data of a geometric body for matching, and particularly for use in facial matching, comprises a three dimensional scanner for obtaining three-dimensional topographical data of the body, a triangulator for receiving or forming said data into a triangulated manifold, a geodesic converter, for converting the triangulated manifold into a series of geodesic distances between pairs of points of the manifold, and a multi-dimensional scaler, for forming a low dimensional Euclidean representation of the series of geodesic distances, to give a bending invariant representation of the geometric body. In one variant, matching is carried out by taking the principle eigenvalues from the representation and plotting as co-ordinates in a feature space. Tilted or different expression versions of the same face tend to form clusters in the feature space allowing for matching. The apparatus preferably uses the fast marching method for the triangulated domain to obtain the geodesic distances.Type: ApplicationFiled: September 6, 2005Publication date: November 9, 2006Applicant: Technion Research & Development Foundation Ltd.Inventors: Alexander Bronstein, Michael Bronstein, Ron Kimmel
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Publication number: 20060253181Abstract: An implantation device comprising a hollow tube for locating an electrode of a lead of a lead adjacent to or in contact with a nerve, muscle or organ in living tissue. The device includes an opening extending the length of the device adapted for introducing and releasing a lead from the tube. The distal end of the device includes a sharpened edge for penetrating through tissue and defines a recess adapted to retain the electrode as the device penetrates into tissue. The electrode is released from the device as it is withdrawn from the tissue. The electrode may be formed of metal having shape memory configured to wrap around a neuromuscular pathway.Type: ApplicationFiled: May 4, 2006Publication date: November 9, 2006Applicant: Alfred E. Mann Foundation for Scientific ResearchInventors: Joseph Schulman, Yitzhak Zilberman
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Publication number: 20060251480Abstract: A tool holder assembly and method for intentionally inducing modulation in a machining process. The tool holder assembly is configured for mounting in a tool block on a machining apparatus and includes a tool holder body configured to be secured to the tool block of the machining apparatus, a tool holder mounted on the tool holder body and configured for securing a cutting tool thereto, and a device for imposing a superimposed modulation on the tool holder so as to move the cutting tool relative to the tool holder body and thereby relative to the tool. The tool holder assembly is useful in a process for producing chips having a desired shape and size, and particularly to a method of controllably producing nanocrystalline chips.Type: ApplicationFiled: May 3, 2006Publication date: November 9, 2006Applicant: Purdue Research FoundationInventors: James Mann, Srinivasan Chandrasekar, Walter Compton
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Publication number: 20060248980Abstract: A products having at least a portion thereof with a nanocrystalline microstructure, and methods of producing such products. The method generally entails machining a body to produce a polycrystalline chip having a nanocrystalline microstructure. The chips produced by the machining operation may be in the form of particulates, ribbons, wires, filaments and/or platelets. The chips may be consolidated (with or without comminution) to form a product, such that the product is essentially a nanocrystalline monolithic material consisting essentially or entirely of nano-crystals, or of grains grown from nano-crystals. Alternatively, the chips may be dispersed in a matrix material, such that the product is a composite material in which the chips are dispersed as a reinforcement material. According to a particular aspect, a monolithic article can be formed entirely from a single chip by deforming the chip and/or removing material from the chip.Type: ApplicationFiled: May 3, 2006Publication date: November 9, 2006Applicant: Purdue Research FoundationInventors: James Mann, Srinivasan Chandrasekar, Walter Compton
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Patent number: 7134082Abstract: A method for individualizing an Internet/Intranet global directory and for adaptively changing the global directory structure based upon the individual alterations of multiple users. The method provides a default computer directory of prearranged files on a server computer. Client directory customization data is then provided to the server computer. With this information, the default directory is reconfigured into an individualized Internet/Intranet directory by modifying a copy of the default Internet/Intranet directory based upon the directory customization data. Further aspects include the step of updating the client directory customization data based upon user inputs; the step of collecting a history of client directory customization data; or the step of updating the default computer directory based on a history of client customization data.Type: GrantFiled: December 4, 2001Date of Patent: November 7, 2006Assignee: Louisiana Tech University Research Foundation as a division of the Louisiana Tech University FoundationInventor: Chee Hung Ben Choi
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Patent number: 7132754Abstract: A flip chip stack of integrated circuits for minimum volume packaging with interconnected chips attached to one or two sides of a flexible circuit board where stacking arrangements for two, five and six chips are disclosed.Type: GrantFiled: December 16, 2005Date of Patent: November 7, 2006Assignee: Alfred E. Mann Foundation for Scientific ResearchInventor: Siegmar Schmidt
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Patent number: 7133041Abstract: An apparatus and method for real-time volume processing and universal three-dimensional rendering. The apparatus includes a plurality of three-dimensional (3D) memory units; at least one pixel bus for providing global horizontal communication; a plurality of rendering pipelines; at least one geometry bus; and a control unit. The apparatus includes a block processor having a circular ray integration pipeline for processing voxel data and ray data. Rays are generally processed in image order thus permitting great flexibility (e.g., perspective projection, global illumination). The block processor includes a splatting unit and a scattering unit. A method for casting shadows and performing global illumination in relation to light sources includes sweeping a two dimensional array of rays through the volume can also be implemented with the apparatus. A method for approximating a perspective projection includes using parallel projection.Type: GrantFiled: February 26, 2001Date of Patent: November 7, 2006Assignee: The Research Foundation of State University of New YorkInventors: Arie E. Kaufman, Ingmar Bitter, Frank Dachille, Kevin Kreeger, Baoquan Chen
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Patent number: 7133083Abstract: A technique and system for detecting a radiometric variation/artifacts of a front-projected dynamic display region under observation by at least one camera. The display is comprised of one or more images projected from one or more of a plurality of projectors; the system is preferably calibrated by using a projective relationship. A predicted image of the display region by the camera is constructed using frame-buffer information from each projector contributing to the display, which has been geometrically transformed for the camera and its relative image intensity adjusted. A detectable difference between a predicted image and the display region under observation causes corrective adjustment of the image being projected from at least one projector.Type: GrantFiled: December 9, 2002Date of Patent: November 7, 2006Assignee: University of Kentucky Research FoundationInventors: Christopher O. Jaynes, Stephen B. Webb, Robert M. Steele
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Patent number: 7132405Abstract: The present invention relates to the targeted delivery of a delivery vehicle construct which specifically binds to and stimulates endocytosis into cells expressing the urokinase plasminogen activator receptor (uPAR), and particularly human airway epithelia. The delivery vehicle construct comprises a portion of uPA and a cargo linked thereto and is useful for the targeted delivery of the cargo to a cell. In one aspect of the invention, the uPA portion of the delivery vehicle construct comprises the wild-type uPA, a fragment of uPA which has the PAI-1 binding region deleted, or a uPA peptide comprising amino acids 13–19 and is useful for the targeted delivery of the cargo to cells, and in particular to airway epithelia. The present invention also provides a method for delivering the delivery vehicle construct to a cell.Type: GrantFiled: May 21, 2003Date of Patent: November 7, 2006Assignee: The University of Iowa Research FoundationInventors: Michael J. Welsh, Paola T. Drapkin
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Patent number: 7132243Abstract: A process for clonally expanding T cells of unknown specificity and a process for identifying a peptide ligand recognized by said T cells are provided.Type: GrantFiled: September 26, 2001Date of Patent: November 7, 2006Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research InstituteInventors: Sho Matsushita, Toshihiro Nakashima
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Patent number: 7132237Abstract: The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.Type: GrantFiled: March 13, 2002Date of Patent: November 7, 2006Assignee: Mayo Foundation for Medical Education and ResearchInventors: Mark J. Federspiel, Stephen J. Russell, Pranay D. Khare
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Patent number: 7132525Abstract: Isolated fragments of an Erwinia hypersensitive response elicitor protein or polypeptide that elicit a hypersensitive response in plants and isolated DNA molecules that encode those fragments are disclosed. Isolated fragments of hypersensitive response elicitor proteins or polypeptides, which elicit a hypersensitive response, and the isolated DNA molecules that encode them can be used to impart disease resistance to plants, to enhance plant growth, and/or to control insects on plants, either by applying the hypersensitive response eliciting fragments to plants or plant seeds or by providing transgenic plants or plant seeds transformed with a DNA molecule encoding a hypersensitive response eliciting fragment.Type: GrantFiled: March 12, 2003Date of Patent: November 7, 2006Assignees: Cornell Research Foundation, Inc., Eden BioScience CorporationInventors: Ron J. Laby, Zhong-Min Wei, Steven V. Beer