Abstract: Physiology simulation garments, systems including physiology simulation garments, and methods of using the same are described herein.

Abstract: The present invention relates to apolipoprotein A-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising the same. More specifically, the apolipoprotein A-1 mimic peptides of the present invention were manufactured by modifying hydrophilic or hydrophobic face of existing 4F amphipathic peptides to produce Apo A-I mimic peptides which specifically bind with cholesterol ester to allow high density lipoprotein content to increase, and the peptide of which phenylalanine in hydrophobic face of 4F is substituted with 2-naphthylalanine has superior cholesterol efflux capability and cognitive function for lipids to the existing 4F peptides, among the mimic peptides. Thus, the Apo A-I mimic peptides of the present invention can be used as Apo A-I mimic peptides and as a therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia.

Abstract: Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.

Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference.

Abstract: Contrast agents comprising a scaffold protein having at least one operative integrated metal ion binding site.

Abstract: The present disclosure provides a DNA molecule capable of replication in Mycobacteria having a nucleic acid sequence as disclosed in SEQ ID NO: 1, a shuttle vector constructed using it and a transformed cells containing the present vector. The vector of about 18 kb of the present disclosure contains 16 ORFs, a replication origin and a rep-like protein essential for replication. Therefore, the plasmid of the present disclosure can be utilized as a gene delivery system/research, and also in a therapeutic system such as immune therapeutics by effectively delivering proteins or heterologous DNA and expressing the encoded DNA in cells.

Abstract: Embodiments of the present disclosure provide for devices, methods for forming non-spherical particles, and the like.

Abstract: The present invention relates to a compound as a peroxisome proliferator activated receptor (PPAR) activator and a hydrate, a solvate, a stereoisomer and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition, a cosmetic composition, a muscle strengthening agent, a memory improving agent, a therapeutic agent for dementia and Parkinson's disease, a functional food and a feed composition containing the same.

Abstract: Provided is a data reception error reduction system and method in acoustic communication in audible frequency range, and an apparatus applied thereto. The data reception error reduction system in the acoustic communication in audible frequency range may be configured to reduce a data reception error in a receiver by taking into consideration that a sound signal is noisy and is significantly affected by a change in the ambient environment when the acoustic communication is performed in the audio frequency band through modification of an audio signal or adding of a predetermined signal to an audio signal. Accordingly, the data reception error may be reduced in the receiver even in an environment where a sound signal is noisy and is significantly affected by a change in the ambient environment, and reliability of data transmission may increase.

Abstract: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence difference.

Abstract: A semiconductor electrode for a dye-sensitized solar cell, a method of manufacturing the semiconductor electrode, and a dye-sensitized solar cell having the semiconductor electrode are provided which can prevent electrons from being transported to an electrolyte from the surface of the semiconductor electrode to raise photocurrent and photovoltage and to improve an energy conversion efficiency by forming a semiconductor oxide layer on a conductive substrate, forming an organic layer in a core-shell structure thereon, and adsorbing a dye on the organic layer through the use of an electrostatic attraction.

Abstract: The present disclosure relates generally to systems and methods for the photo-inactivation of microorganisms. More specifically, the present invention is directed towards the photo-inactivation of microorganisms, such as viruses, using at least one furanocoumarin and broad spectrum pulsed light. For example, an aspect of the present invention includes a method for inactivating a herpesvirus, such as herpes B virus or herpes virus papio 2 using a psoralen and broad spectrum pulsed light.

Abstract: This study reports in vitro and in vivo properties of fluorapatite (FA)-forming calcium phosphate cements (CPCs). Experimental cements contained from (0 to 3.1) mass % of F, corresponding to presence of FA at levels of approximately (0 to 87) mass %. The crystallinity of the apatitic cement product increased greatly with the FA content. When implanted subcutaneously in rats, the in vivo resorption rate decreased significantly with increasing FA content. The cement with the highest FA content was not resorbed in soft tissue, making it biocompatible and bioinert CPC. These bioinert CPCs are candidates for use in useful applications where slow or no resorption of the implant is required to achieve the desired clinical outcome.

Abstract: An embodiment of the invention is a soft tissue impact assessment device. The device includes a skin that is shaped or moldable to a human-like form. A positional force or pressure sensor within the skin measures force or pressure and location of impact or contact with the skin and provides data regarding the force or pressure and location of impact or contact with the skin. In preferred embodiments, the skin includes a top layer made of a material and thickness that simulates the protection provided by particular human skin to underlying tissue. A pressure or force sensor sheet closely contacts the top layer in a manner that avoids any substantial movement between the top layer and the pressure or force sensor sheet during a range of anticipated force or pressure conditions to be experienced by the human surrogate during testing. A lining layer is suitable to be in close contact with a surface of a human like form.

Abstract: A method and system that compensates for thermal induced stresses in structures composed of different materials fastened together. The system utilizes three compensation mounts made from a material with a coefficient of thermal expansion that is between that of the two materials being fastened together. These mounts can be linear or, for a thinner structure, the mounts are “C” shaped. The size of the “C” mounts and fastening locations are calculated based on the coefficient of thermal expansion for the two materials being fastened together and the “C” mount material. The geometry of the “C” mounts allows for fastening the two planar surfaces without introducing a large thickness increase to the structure. This system allows for materials to be fastened together, and when placed in an environment with temperature fluctuations, the system experiences zero, minimal or insignificant amounts of thermal induced stress.

Abstract: Fluid transfer devices for use in, for example, ambulatory infusion devices and infusions devices including fluid transfer devices.

Abstract: Provided are fabrication, characterization and application of a nanodisk electrode, a nanopore electrode and a nanopore membrane. These three nanostructures share common fabrication steps. In one embodiment, the fabrication of a disk electrode involves sealing a sharpened internal signal transduction element (“ISTE”) into a substrate, followed by polishing of the substrate until a nanometer-sized disk of the ISTE is exposed. The fabrication of a nanopore electrode is accomplished by etching the nanodisk electrode to create a pore in the substrate, with the remaining ISTE comprising the pore base. Complete removal of the ISTE yields a nanopore membrane, in which a conical shaped pore is embedded in a thin membrane of the substrate.

Abstract: This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.

Abstract: Materials and methods for using biomarkers to determine prognosis and response to treatment in subjects having chronic vascular dysfunction.

Abstract: A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor cells.