Abstract: The present invention provides a method of purifying cross-linked oligomers. The purified cross-linked oligomers are useful as immunogen for generating and isolating cross-linked oligomer reactive antibodies. The cross-linked oligomer reactive antibodies are useful for detecting amyloid deposition and for diagnosing and treating diseases and conditions associated with amyloid deposition.

Abstract: A method and apparatus for recharging a battery of a mobile station are provided which can re-receive a signal emitted from an electromagnetic resonant circuit and automatically recharge the battery having the smallest remaining amount sequentially when a quantity of electric charges remaining in the battery is equal to or less than a reference value while the mobile station is utilizing a mobile communication service. The method includes the steps of: radiating the signal emitted from the electromagnetic resonant circuit; re-receiving the signal emitted from the electromagnetic resonant circuit; activating a conversion of power of the re-received signal; and charging the battery on the basis of a signal obtained by rectifying the re-received signal in accordance with the conversion of power.

Abstract: A radiation detection system and method suitable for use by a first responder to detect a radiological source. The system includes a container that encloses a chamber containing a pressurized inert gas. Incident gamma rays pass through walls of the container to interact with inert gas atoms within the chamber. Wavelength-shifting fiber elements are disposed within scintillator bars oriented parallel to and radially spaced from the chamber axis. At least one sensor is interconnected with the fiber elements to receive first signals therefrom in response to the scattered gamma rays. An electrically-charged wire is disposed within the container along the axis thereof. The wire is adapted to attract electrons released from atoms of the inert gas that are ionized from being impacted by an incident gamma ray, and then produce second signals in response to the released electrons.

Abstract: The ?-trefoil protein human fibroblast growth factor-1 (FGF-1) is made up of a six-stranded anti-parallel ?-barrel closed off on one end by three ?-hairpins, thus exhibiting a three-fold axis of structural symmetry. The N- and C-termini ?-strands hydrogen bond to each other and are postulated from both NMR and X-ray structure data to represent a structurally-weakened region of the ?-barrel. Val mutations within the N- and C-termini ?-strands are shown to stabilize the structure and to increase van der Waals contacts by filling local cavities present within this region. Mutations that increase van der Waals contacts between both the N- and C-termini ?-strands are generally associated with significant reductions in the unfolding kinetics, and also increase the cooperativity of unfolding. Surprisingly, several mutant polypeptides herein disclosed greatly exceed the wild-type polypeptide in ability to stimulate human fibroblasts to proliferate.

Abstract: A method is provided for detecting an analyte indicative of a cancer or a metastatic disease condition, which utilizes the ability of the analyte to induce permeability in a barrier. The method includes providing a biosensor having a barrier which is substantially impermeable to an ion, a permeable membrane which is selective for the ion, and a detector capable of detecting the ion. The biosensor is contacted with a sample including at least one of the ion and the analyte, wherein the analyte causes at least a portion of the ion to pass through the barrier and the membrane. Passage of the ion through the barrier and membrane allows detection of the ion, providing indirect detection of the analyte. In one embodiment, the barrier is a cell monolayer, the membrane is selective for potassium, and the analyte is vascular endothelial cell growth factor.

Abstract: The present invention provides molecules and methods for the prevention and/or treatment of memory deficit related conditions and/or enhancement of cognizance. In a preferred embodiment, the invention includes compounds, salts and prodrugs thereof for the prevention and/or treatment of these conditions.

Abstract: The present invention relates to the preparation of a series of oxidized cellulose esters suitable for use as a drug carrier in the development of biodegradable controlled and/or sustained release pharmaceutical, agricultural, and veterinary compositions, such as films, compacts, microspheres, and pellets. The esters are prepared by acylation of oxidized cellulose having at least 3% carboxyl groups. The resulting oxidized cellulose esters are soluble in aqueous alkaline solutions, water, and a variety of organic solvents.

Abstract: A method for expanding the domain of imaging software in a diagnostic work-up includes the steps of: imaging a patient's body parts for a first condition using a first imaging technique directed to a first condition; acquiring known patient risk factors indicating a second condition; compensating for differences in accuracy between a first imaging technique directed to a first condition, and a second imaging technique directed to testing for the second condition to generate a set of measures; placing a range and confidence interval around the set of measures; and evaluating for a second condition using the set of measures and known patient risk factors.

Abstract: The present invention is related to a method for modulating the immune system of a mammal patient towards an allergen, which comprises the step of inducing a pre-sensitisation of the immune system of said patient towards an immunogen carrying at least one T cell epitope homologous and functionally similar to an epitope present on said allergen and deriving from a naturally-occurring antigen in order to modify the response of said patient to a further sensitisation to said allergen, allowing that the immune response towards the allergen is modulated and that no allergy towards said allergen will be developed in said patient.

Abstract: The invention provides methods to identify moieties which specifically bind the flap-tip helix of the ? subunit of RNA polymerase and to identify inhibitors of the interaction between those moieties and the flap-tip helix.

Abstract: An apparatus and method for capillary zone electrophoresis includes a polyelectrolyte multilayer positioned in a capillary tube for analytical separations of macromolecules. The capillary comprises a passage defined by passage walls comprising fused silica. The polyelectrolyte multilayer is positioned within the passage adjacent the walls, and comprises an organic polyelectrolyte. The passage may further comprise nonporous silica particles coated with a multilayer including a plurality of polyelectrolyte layers. An apparatus includes a power supply having a positive electrode and a negative electrode for generating an electric field therebetween. The apparatus includes a capillary having a passage formed by passage walls and comprising therein a polyelectrolyte multilayer positioned substantially within the passage.

Abstract: A computer-assisted detection method is provided for detecting suspicious locations of lesions in the volumetric medical images. The method includes steps of features extraction and fusion. The first step is computing gradient feature for extraction of the layer of Partial Volume Effect (LPVE) between different tissues that related to specific organs. The LPVE will combine with the result of voxel classification to fulfill the task of tissue classification. After tissue classification, the contour of tissue boundary is determined. The gradient feature is also used to determine the direction that intensity changes. This direction that intensity changes most dramatically serves as the normal vector for voxel on the contour of the tissue boundary. The second step is to determine a local surface patch on the contour for each voxel on the contour. A local landmark system is then created on that patch and the so-called Euclidean Distance Transform Vector (EDTV) is computed based on those landmarks.

Abstract: The present invention features a qualitative method to detect independent motion revealed in successive frames of a compressed surveillance MPEG video stream using linear system consistency analysis without decompression of the stream, identifying the segments containing independent motion in a real-time or faster manner, for the retrieval of these segments. The linear system is constructed using the macroblocks of MPEG compressed video frames. The normal flow value of the macroblock is obtained by taking the dot product between the macroblock gradient vector, computed by averaging the four block gradient vectors, and the motion vector of this macroblock. The normal flow value is filtered for inclusion in the linear system, and the statistic of the matrices of the resulting linear system is determined, filtered to screen out false negatives and outliers, and used to determine the presence or absence of independent motion.

Abstract: Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also provided is a Ccl2-deficient, Ccr2-deficient dual knockout mouse, which is a useful animal model for age-related macular degeneration.

Abstract: Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed.

Abstract: A time-mode analog computation circuit is provided. The time-mode analog computation circuit includes one or more inputs for receiving one or more temporal input signals. The time-mode analog computation circuit further includes circuitry for performing a mathematical operation based on the one or more temporal input signals. A result of the mathematical operation is expressed in a timing of an output signal generated by the circuit.

Abstract: A method of rejuvenating Leydig cells in a subject having Leydig cells is disclosed. Rejuvenation of Leydig cells is accomplished, in one embodiment, by coadministering TH and LH to a subject. Rejuvenating Leydig cells can enhance serum testosterone levels and can have other desirable effects as well. The presently claimed subject matter also encompasses methods relating to the treatment of andropause and the elevation of serum testosterone levels.

Abstract: Novel, monodispersed, spherical ZrO2 particles in the size range of approximately 10 to approximately 600 nm exhibiting metastable tetragonal crystal structure at room temperature and novel methods of preparation. The ZrO2 particles are approximately 100% in the tetragonal phase at room temperature and can be pure and free of foreign oxides. The novel method can include mixing zirconium-alkoxide and an alcohol, forming preparation one, followed by separately dissolving completely de-ionized water and a polymeric steric stabilizer in an alcohol forming preparation two. Next the preparations can be mixed with vigorous stirring while subjecting the materials to hydrolysis and condensation reactions with very slow stirring. Next, there is waiting for the formation of a sol from the mixture, followed by drying at approximately 80 degrees C. to form resultant material followed by crushing the resultant material.

Abstract: An apparatus and method for reducing EMI generated by a power conversion device, as well as a power conversion device employing such apparatus or method (and/or devices employing such a power conversion device) are disclosed. In at least some embodiments, the apparatus includes a hybrid filter for use in reducing EMI. The hybrid filter includes a passive filtering component, and an active filtering component coupled at least indirectly to the passive filtering component. The active filtering component includes a voltage controlled voltage source, and the hybrid filter operates to reduce a level of a common mode current, whereby the EMI generated due to the common mode current is reduced.

Abstract: Disclosed is a method for transmitting and receiving data according to a channel state in a wireless communication system, the method includes measuring a characteristic of transmission channels used for data transmission and transmitting channel state information of the measured channel characteristic; and selecting sub-channels for data transmission according to the channel state information, and transmitting data through the selected sub-channels.