Abstract: Disclosed herein are systems and methods to detect a wide range of eardrum abnormalities by using high-resolution otoscope images and report the condition of the eardrum as “normal” or “abnormal.
Type:
Grant
Filed:
September 1, 2017
Date of Patent:
March 2, 2021
Assignee:
Ohio State Innovation Foundation
Inventors:
Caglar Senaras, Aaron Christopher Moberly, Theodoros Teknos, Garth Fredric Essig, Jr., Charles Albert Elmaraghy, Nazhat Fatima Taj-Schaal, Lianbo Yu, Metin Nafi Gurcan
Abstract: The present invention relates to a composition comprising a Ttyh1 gene expression inhibitor or a Ttyh1 protein activity inhibitor, and a method of preventing or treating Alzheimer's disease using the same.
Type:
Grant
Filed:
June 27, 2019
Date of Patent:
March 2, 2021
Assignee:
Research & Business Foundation Sungkyunkwan University
Abstract: Disclosed is a liquid hydrogen storage material, and more particularly, a hydrogen storage material which contains m-phenyltoluene (m=2, 3) and undergoes reversible dehydrogenation/hydrogenation reactions or contains a binary eutectic mixture or a ternary eutectic mixture of m-phenyltoluene (m=2, 3, 4).
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
March 2, 2021
Assignee:
Korea University Research and Business Foundation
Abstract: Disclosed are next-generation multi-mutated capsid protein-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using these high transduction efficiency vector constructs in a variety of therapeutic applications including, inter alia, as delivery agents for the treatment or amelioration of one or more diseases or abnormal conditions in an affected mammal using in vivo and/or ex situ viral vector-based gene therapy protocols. Also disclosed are large-scale production methods for the multi-mutated, capsid-modified rAAV expression vectors, viral particles, and infectious virions, as well as use of the disclosed compositions in the manufacture of medicaments for use in a variety of in vitro and/or in vivo therapeutic methodologies.
Type:
Grant
Filed:
November 28, 2017
Date of Patent:
March 2, 2021
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Arun Srivastava, Li Zhong, Sergei Zolotukhin, George Vladimirovich Aslanidi, Mavis Agbandje-McKenna, Kim M. Van Vliet, Chen Ling
Abstract: A three-dimensional phantom for providing displacement profiles for a CT table having 6 degrees of freedom includes a body having at a top face, a side face and an end face; the top face and the side face sharing a common edge; the top face and the end face sharing a common edge; and the side face and the end face sharing a common edge; wherein an angle formed by the top face and the end face is less than 90 degrees; the side face including a first isocenter mark and a first offset mark, wherein the first offset mark has an angle corresponding to the angle formed by the top face and the end face; and an isocenter marker at the isocenter of the body.
Type:
Grant
Filed:
August 17, 2018
Date of Patent:
March 2, 2021
Assignee:
Ohio State Innovation Foundation
Inventors:
Kyle Woods, Ahmet Ayan, Jeffrey Woollard, Nilendu Gupta
Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.
Type:
Grant
Filed:
November 28, 2018
Date of Patent:
March 2, 2021
Assignees:
Mayo Foundation for Medical Education and Research, Exact Sciences Development Company, LLC
Inventors:
David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Tracy C. Yab, John B. Kisiel, Hatim T. Allawi, Graham P. Lidgard, Michael W. Kaiser
Abstract: A transmitter includes a driver circuit configured to drive a channel connected to a first node by controlling a turn-on impedance of a pull-up path, a turn on impedance of a pull-down path, or both according to a plurality of control signals; an encoder configured to generate the plurality of control signals according to a multi-bit data and a calibration signal; and a calibration circuit configured to generate the calibration signal including calibration information corresponding to the plurality of control signals, wherein the encoder determines activation and magnitude of each of the plurality of control signals according to the multi-bit data and the calibration information.
Type:
Grant
Filed:
November 25, 2019
Date of Patent:
March 2, 2021
Assignees:
SK hynix Inc., Seoul National University R&DB Foundation
Abstract: An analog-to-digital converter (ADC) includes a first operator configured to subtract an analog value from an analog signal; an amplifier configured to amplify an output of the first selector; a filter configured to filter an output of the amplifier; a quantizer configured to generate a digital bit stream from an output of the filter; and a digital-to-analog converter (DAC) configured to output the analog value according to the digital bit stream.
Type:
Grant
Filed:
February 13, 2020
Date of Patent:
March 2, 2021
Assignee:
Seoul National University R&DB Foundation
Abstract: A battery charging and discharging apparatus includes power converters connected in series and configured to convert respective output voltages of batteries corresponding to the power converters. Each of the power converters may include direct current to direct current (DC/DC) converters connected in parallel. The apparatus may further include a controller configured to control magnitudes of respective output voltages of the power converters based on respective states of the batteries.
Type:
Grant
Filed:
October 22, 2019
Date of Patent:
March 2, 2021
Assignees:
Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan University
Abstract: A device for and a method of monitoring the healing status of a fractured bone in a person's limb is disclosed. The external fixation device may include one or more rods or struts that incorporate strain gauges designed to measure the mechanical forces on the strut when force is applied to the fractured bone. The mechanical force data may be collected by an electronic module and transmitted to a computer for statistical analysis. The device may also include a foot insole sensor for measuring the foot plantar force to normalize the data collected by an external fixation device attached to a person's leg. The method of measuring the healing status of a fractured bone includes measuring the changes in mechanical forces exerted on the one or more struts, and based on the measurements, estimating the healing status of the bone.
Abstract: The invention relates to a method of removing and/or recovering metals from a dilute metal containing solution. In particular, the invention concerns a method for recovering copper from a dilute copper-iron bearing mining water, particularly from a copper-iron bearing mining wastewater.
Abstract: The invention provides a series of conformationally stable and selective kinase inhibitors, and methods of using the kinase inhibitors. The effect of atropisomerism on kinase selectivity was assessed, finding improved selectivity compared to rapidly interconverting parent compounds. The compounds herein are atropisomers having increased kinase selectivity, and are for use in treating conditions that benefit from selective kinase inhibition.
Type:
Grant
Filed:
June 21, 2018
Date of Patent:
March 2, 2021
Assignee:
San Diego State University (SDSU) Foundation
Inventors:
Jeffrey L. Gustafson, Sean T. Toenjes, Sean M. Maddox
Abstract: An HVAC register airflow control system and an air flow control method are provided. A housing of the system is in fluid communication with an air source for supplying an airflow. The housing includes an air outlet to the enclosed space. A detection sensor detects occupancy information of the enclosed space. A controller generates a control signal based on the occupancy information and controls the shape change of a damper made of a shape memory material. The damper is controlled to switch between a first operative configuration for preventing the airflow from entering the enclosed space and a second operative configured for permitting the airflow to enter the enclosed space.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
March 2, 2021
Assignee:
The Research Foundation for The State University of New York
Abstract: The present invention provides a silicon nanowire structure embedded in nickel silicide nanowires for lithium-based battery anodes and anodes including the same. In particular, a Si nanowire structure embedded in NiSix nanowires according to the present invention may provide a solution to a problem, such as disconnection of Si nanowires from a current collector shown when the Si nanowires are expanded by alloying with Li or contracted during the use of a battery, and the like, by flexibly embedding the Si nanowires in the NiSix nanowires.
Type:
Grant
Filed:
May 1, 2019
Date of Patent:
March 2, 2021
Assignees:
Hyundai Motor Company, Research & Business Foundation Sungkyunkwan University, Kia Motors Corporation
Inventors:
Kyo Min Shin, Sa Heum Kim, Hong Seok Min, Mihai Robert Zamfir, Je Mee Joe, Didier Pribat, Yeo Jin Lee
Abstract: A method of improving data sets, for example, of patients, each being characterized by relatively low-cost medical data, identifies those patients where the acquisition of higher cost medical data would best inform an estimate of the higher cost medical data for the remaining patients. In this way scarce medical resources can be more efficiently applied in characterizing a potential patient pool, for example, for a clinical trial when resources are not available for extensive medical characterization of each trial participant.
Type:
Grant
Filed:
October 25, 2016
Date of Patent:
March 2, 2021
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Won Hwa Kim, Seong Jae Hwang, Nagesh Adluru, Sterling Johnson, Vikas Singh
Abstract: A successive approximation register (SAR) analog-to-digital converter (ADC) includes a first digital-to-analog converter (DAC) coupled to receive a first input voltage to generate a first output voltage; a second DAC coupled to receive a second input voltage to generate a second output voltage; a comparator having a positive input node coupled to receive the first output voltage of the first DAC, and a negative input node coupled to receive the second output voltage of the second DAC; a SAR controller that controls switching of the first DAC and the second DAC according to a comparison output of the comparator, thereby generating an output code; a first calibration circuit coupled between the positive input node of the comparator and a ground voltage; and a second calibration circuit coupled between the negative input node of the comparator and the ground voltage.
Type:
Grant
Filed:
July 29, 2020
Date of Patent:
March 2, 2021
Assignees:
NCKU Research and Development Foundation, Himax Technologies Limited
Abstract: The present invention relates to a system for estimating a degree of distraction based on unconstrained bio-information. The present invention provides a system for estimating a degree of distraction based on unconstrained bio-information, the system comprising: a degree-of-distraction measurement chair comprising a seating unit, a message transmission unit, a pressure detection unit, and a support unit, which are formed in this order from the top to the bottom thereof, wherein the pressure detection unit formed on the support unit comprises a smart sensor including three load cells arranged at three vertices of a triangular shape on a plane; and a mobile smart terminal configured to receive information regarding the degree of distraction from the message transmission unit of the degree-of-distraction measurement chair through the Bluetooth communication.
Type:
Grant
Filed:
February 18, 2016
Date of Patent:
March 2, 2021
Assignee:
Dongseo University Industry-Academic Cooperation Foundation
Inventors:
Woo Jin Hwang, Do Un Jeong, Gi Hyun Hwang, Dae-Soo Cho
Abstract: Described is a recombinant expression vector that enables a cell transformed to contain and express the vector to use levulinic acid as a carbon source, thereby converting levulnic acid into 2-butanne. Also described are genetically modified cells transformed to contain and express the vector and methods of using the cells to produce 2-butanone from a medium containing levulinic acid.
Type:
Grant
Filed:
September 19, 2018
Date of Patent:
March 2, 2021
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Brian Frederick Pfleger, Jacqueline Marie Rand, Christopher Robert Mehrer, Matthew Ryan Incha
Abstract: A new Ilex plant named ‘RutHol3’ is characterized by a combination of its upright, narrow growth habit, its attractive burgundy new growth, its glossy green mature foliage, its quick growth and resistance to spider mites.
Type:
Grant
Filed:
December 5, 2019
Date of Patent:
March 2, 2021
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: ‘UF16-91-25’ is a new Coleus plant with a combination of novel characteristics that include vigorous compact mounded growth habit, excellent heat tolerance, and consistent tri-colored pink, maroon, and lime green foliage. ‘UF16-91-25’ has superior stability in foliage color in both sun and shade conditions, maintaining stable color in all conditions. ‘UF16-91-25’ has not been observed to produce flowers in any trial conducted to date, so it has long season performance as an annual plant in the landscape until late Fall.