Patents Assigned to Fraunhofer, USA
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Publication number: 20210324015Abstract: A fusion protein comprising a target protein, a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The target protein is at N-terminus of the first recombinant viral coat protein. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may further comprise a second linkage peptide between the target protein and the first recombinant viral coat protein. The fusion protein may form a virus like particle (VLP). The target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.Type: ApplicationFiled: June 29, 2021Publication date: October 21, 2021Applicant: Fraunhofer USA Inc.Inventors: Stephen Tottey, Konstantin Musiychuk
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Publication number: 20210323848Abstract: An electrode apparatus for removing contaminants from a fluid is provided. In another aspect, an electrochemical destruction apparatus for wastewater effluent using Boron-doped diamond electrodes is employed. A further aspect of the present apparatus includes a fluid-carrying conduit, electrodes located within the conduit, an electrical controller connected to the electrodes, a sensor connected to the controller being adapted to sense a chemical characteristic associated with contaminants in the fluid, and the controller automatically varying an electrical characteristic associated with at least one of the electrodes based, at least in part, on an input from the sensor. Yet another aspect includes a programmable controller and software which automatically employ a feedback control loop to increase or decrease electrical current density to contaminant-removing electrodes.Type: ApplicationFiled: April 13, 2021Publication date: October 21, 2021Applicants: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Thomas SCHUELKE, Mary K. ENSCH, Michael BECKER, Cory A. RUSINEK
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Patent number: 11078240Abstract: A fusion protein comprising a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may form a virus like particle (VLP). Where the fusion protein further comprises a target protein, the target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.Type: GrantFiled: November 10, 2017Date of Patent: August 3, 2021Assignee: Fraunhofer USA Inc.Inventors: Stephen Tottey, Konstantin Musiychuk
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Patent number: 11073494Abstract: A trace metal analysis detector and method of operating the same to detect metals in various fluid samples using boron doped diamond working electrodes.Type: GrantFiled: August 8, 2016Date of Patent: July 27, 2021Assignee: Fraunhofer USA, Inc.Inventors: Michael Frank Becker, Thomas Schuelke
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Patent number: 11049697Abstract: A single beam plasma or ion source apparatus is provided. Another aspect employs an ion source including multiple magnets and magnetic shunts arranged in a generally E cross-sectional shape. A further aspect of an ion source includes magnets and/or magnetic shunts which create a magnetic flux with a central dip or outward undulation located in an open space within a plasma source. In another aspect, an ion source includes a removeable cap attached to an anode body which surrounds the magnets. Yet a further aspect provides a single beam plasma source which generates ions simultaneously with target sputtering and at the same internal pressure.Type: GrantFiled: June 19, 2019Date of Patent: June 29, 2021Assignees: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Qi Hua Fan, Thomas Schuelke, Lars Haubold, Michael Petzold
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Publication number: 20210147974Abstract: A magnetic-field-assisted plasma coating system and method are provided. In another aspect, a coating system employs a cathode with a linearly moveable magnetic field. A further aspect employs a workpiece as an anode within which is located an elongated cathode which internally coats a bore of the workpiece. Still another aspect of the present system and method employs an elongated and hollow cathode with at least one magnetic source therein. In yet another aspect, end caps or plates seal against one or more open ends of a workpiece bore to be coated, with a cathode inserted into the bore and a vacuum being created within the bore such that the workpiece itself defines at least a portion of a vacuum chamber.Type: ApplicationFiled: June 7, 2018Publication date: May 20, 2021Applicants: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Thomas SCHUELKE, Michael BECKER, Lars HAUBOLD, Qi Hua FAN
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Patent number: 10830671Abstract: An automatic plant tissue sampler and a method for operating the same are provided. The sampler can include a plant handler configured to transport a plurality of plants to an imager. The imager may be configured to image plants to identify a sampling location. The automatic plant tissue sampler also includes a sampler configured to remove a tissue sample from the sampling location of plants, and a collection vessel configured to receive the tissue samples. The automatic plant tissue sampler may transport a plurality of plants to an imager and images the plurality of plants to identify a sampling location. The automatic plant tissue sampler can remove a tissue sample from the sampling location of the plurality of plants and store the tissue samples in a collection vessel for testing.Type: GrantFiled: November 26, 2013Date of Patent: November 10, 2020Assignee: FRAUNHOFER USA, INC.Inventors: Patrick Sercel, Aaron Sharpe, Sudong Shu, Holger Wirz
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Publication number: 20200303236Abstract: An electrode is provided. The electrode includes a contact pad composed of boron-doped polycrystalline diamond (BDD); a fiber core composed of BDD extending longitudinally from the contact pad from a first end that is in direct contact with the contact pad to an opposing second end; and a polycrystalline diamond (PCD) cladding that coats and hermetically seals the contact pad and the fiber core. A first portion of the contact pad and a second portion at or near the second end of the fiber core are not coated and hermetically scaled by the PCD cladding. A method of fabricating the electrode is also provided.Type: ApplicationFiled: September 27, 2018Publication date: September 24, 2020Applicants: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Wen LI, Yue GUO, Thomas SCHUELKE, Michael BECKER, Robert RECHENBERG, Cory RUSINEK
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Publication number: 20200303168Abstract: A single beam plasma or ion source apparatus is provided. Another aspect employs an ion source including multiple magnets and magnetic shunts arranged in a generally E cross-sectional shape. A further aspect of an ion source includes magnets and/or magnetic shunts which create a magnetic flux with a central dip or outward undulation located in an open space within a plasma source. In another aspect, an ion source includes a removeable cap attached to an anode body which surrounds the magnets. Yet a further aspect provides a single beam plasma source which generates ions simultaneously with target sputtering and at the same internal pressure.Type: ApplicationFiled: June 19, 2019Publication date: September 24, 2020Applicants: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Qi Hua FAN, Thomas SCHUELKE, Lars HAUBOLD, Michael PETZOLD
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Publication number: 20200230592Abstract: A pipetting device includes a housing, a valve assembly, and an actuator assembly. The housing includes a tip for receiving a capillary tube. The valve assembly includes a shuttle valve having a filling position and a dispensing position and a valve rod. The actuator assembly includes an actuator, a valve trigger, a piston mount, and an indexing mechanism. The actuator extends from the housing and has a push button coupled to a push rod. The valve trigger being configured to engage the valve assembly and includes an aperture configured to receive the piston mount therein. The indexing mechanism is configured to index a rotated position of the push button to a predefined volume of dispensed fluid.Type: ApplicationFiled: February 14, 2018Publication date: July 23, 2020Applicants: FRAUNHOFER USA, INC., THE CHILDREN'S MEDICAL CENTER CORPORATION, BETH ISRAEL DEACONESS MEDICAL CENTER, INC.Inventors: Alexis Sauer-Budge, Holger Wirz, Samuel J. Brookfield, Nira Pollock, Ronald Janzen
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Publication number: 20200181203Abstract: A fusion protein comprising a first recombinant viral coat protein, a second recombinant viral coat protein and a first linkage peptide is provided. The first recombinant viral coat protein is linked to N-terminus of the first linkage peptide. The second recombinant viral coat protein is linked to C-terminus of the first linkage peptide. The first and second recombinant viral coat proteins are derived from the coat protein (CP) of alfalfa mosaic virus (AIMV). The fusion protein may form a virus like particle (VLP). Where the fusion protein further comprises a target protein, the target protein may be displayed on the surface of the VLP. Also provided are methods for producing the fusion protein and the VLP as well as the uses of the fusion protein and/or the VLP.Type: ApplicationFiled: November 10, 2017Publication date: June 11, 2020Applicant: Fraunhofer USA Inc.Inventors: Stephen Tottey, Konstantin Musiychuk
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Patent number: 10667709Abstract: An implantable device is provided. The implantable device includes a flexible polymeric substrate that extends through an aperture in an electrically conductive material to form an anchor that partially covers the electrically conductive material. Methods for fabricating the implantable device are also provided.Type: GrantFiled: May 26, 2017Date of Patent: June 2, 2020Assignees: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Wen Li, Bin Fan, Robert Rechenberg, Michael Becker, Cory Rusinek
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Publication number: 20200035456Abstract: A material processing apparatus includes a vacuum chamber, an electrically grounded shield and/or workpiece, multiple radio frequency-powered electrodes within the vacuum chamber, magnets, and a gas inlet operable to flow a precursor gas to a plasma area located between the electrodes. In another aspect, magnets and spaced apart radio frequency-powered electrodes are operable to create a magnetic field and a radio frequency field within a plasma, which causes a plasma enhanced chemical vapor deposition of coating material onto a workpiece or substrate within a vacuum chamber.Type: ApplicationFiled: July 24, 2019Publication date: January 30, 2020Applicants: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY, Fraunhofer USAInventors: Qi Hua FAN, Thomas Schuelke, Michael Becker, Bocong Zheng
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Publication number: 20190296683Abstract: Described herein are embodiments of an approach to attaching one or more photovoltaic (PV) modules to a roof of a building. More particularly, described herein are embodiments of an approach to attaching glass-glass PV modules using an adhesive. Such an adhesive may be applied to contact points between the roof and a support frame that holds the glass-glass PV module(s) in place and that may be mechanically coupled to the glass-glass PV module(s). Use of the adhesive in this way may be particularly advantageous when the roof is sloped, including when the roof has a steep slope, which may include roofs having a rise-to-run ratio greater than 4:12, greater than 6:12, or greater than 8:12. The adhesive may, in some embodiments, aid in reducing, minimizing, or eliminating the use of mechanical anchor points that may be needed to support the glass-glass PV module(s) on the roof.Type: ApplicationFiled: March 21, 2018Publication date: September 26, 2019Applicant: Fraunhofer USA, Inc.Inventors: Christian Honeker, Christian Hoepfner, Hans C. Henning
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Publication number: 20190282110Abstract: An implantable device is provided. The implantable device includes a flexible polymeric substrate that extends through an aperture in an electrically conductive material to form an anchor that partially covers the electrically conductive material. Methods for fabricating the implantable device are also provided.Type: ApplicationFiled: May 26, 2017Publication date: September 19, 2019Applicants: Board of Trustees of Michigan State University, Fraunhofer USAInventors: Wen LI, Bin FAN, Robert RECHENBERG, Michael BECKER, Cory RUSINEK
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Patent number: 10381837Abstract: Photovoltaic systems and related techniques are provided. A method for commissioning a photovoltaic (PV) system may include obtaining data describing an arrangement of two or more components of the PV system; performing a test of the PV system, wherein performing the test includes determining whether the PV system complies with at least one PV system criterion based, at least in part, on at least a portion of the data describing the arrangement of the two or more components of the PV system; and in response to determining that the PV system complies with the at least one PV system criterion, activating the PV system and/or notifying a user of the PV system that the PV system complies with the at least one PV system criterion. The method may further include sending information associated with the PV system to a regulatory entity and/or an operator of an electrical grid.Type: GrantFiled: July 14, 2015Date of Patent: August 13, 2019Assignee: Fraunhofer USA, Inc.Inventors: Christian Hoepfner, Dirk E. Mahling, Matthew Alan Kromer, James R. Perkinson
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Publication number: 20180110404Abstract: Disclosed herein is an aspiration assembly for attaching to an endoscope. The aspiration assembly comprises an extendable suction tube for aspirating an object (e.g., smoke, blood, blood clot, bone debris, or tissue debris) at or near a surgical site during an endoscopic surgery. The aspiration assembly can further comprise an irrigation tube for directing a fluid to the surgical site for cleaning the endoscope lens. By integrating an extendable suction tube with the endoscope, the technology described herein obviate the need for instrument switching and/or multiple surgeons during the surgery.Type: ApplicationFiled: April 15, 2016Publication date: April 26, 2018Applicants: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION, FRAUNHOFER USA, INC.Inventors: Anand DEVAIAH, Andre SHARON, Alexis SAUER-BUDGE, Holger WIRZ, Yuzhang YANG, Stephanus Johannes Marcellis VAN DER KEMP, Daniel ECHEVERRIA
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Publication number: 20180087798Abstract: Systems and methods for characterization of retrofit opportunities are described. The methods may comprise computing, using at least one computing device disposed remote from a building and based at least in part on heating, ventilation and air conditioning (HVAC) runtime data associated with the building, one or more thermal characteristics of the building. In some embodiments, a model-predicted indoor temperature may be fitted against thermal data measured by a thermostat at the building. The thermal characteristic of the building may comprise a thermal insulation, an air leakage rate and/or an HVAC efficiency. The method may be used to determine, using the at least one computing device, suitability of the building for a retrofit opportunity to improve energy efficiency of the building. Determining the suitability may comprise evaluating the one or more thermal characteristics. The HVAC runtime data may be computed based on data received from a thermostat or a meter, such as an electric or a gas meter.Type: ApplicationFiled: August 18, 2017Publication date: March 29, 2018Applicant: Fraunhofer USA, Inc.Inventors: Michael Zeifman, Amine Lazrak
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Publication number: 20180068034Abstract: Systems and methods for characterization of retrofit opportunities are described. The methods may comprise computing, using at least one computing device disposed remote from a building and based at least in part on heating, ventilation and air conditioning (HVAC) runtime data associated with the building, one or more thermal characteristics of the building. In some embodiments, a model-predicted indoor temperature may be fitted against thermal data measured by a thermostat at the building. The thermal characteristic of the building may comprise a thermal insulation, an air leakage rate and/or an HVAC efficiency. The method may be used to determine, using the at least one computing device, suitability of the building for a retrofit opportunity to improve energy efficiency of the building. Determining the suitability may comprise evaluating the one or more thermal characteristics. The HVAC runtime data may be computed based on data received from a thermostat or a meter, such as an electric or a gas meter.Type: ApplicationFiled: August 18, 2017Publication date: March 8, 2018Applicant: Fraunhofer USA, Inc.Inventors: Michael Zeifman, Amine Lazrak
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Patent number: 9817045Abstract: Identification and tracking of major electric appliances by using aggregate power data obtained at the main breaker level of a residence or commercial establishment. Step power changes and power surges characterize appliances. These features are identified and the time of use and duration statistics are considered to match an observed sequence of power changes with the appliances being turned on and off. The time-dependent usage of appliances and their power consumption are then reconstructed.Type: GrantFiled: December 13, 2011Date of Patent: November 14, 2017Assignee: Fraunhofer USA, Inc.Inventor: Michael Zeifman