Patents Assigned to Fred Hutchinson Cancer Research Center
  • FLUORESCENT CHLOROTOXIN CONJUGATE AND METHOD FOR INTRA-OPERATIVE VISUALIZATION OF CANCER
    Publication number: 20140241993
    Abstract: A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
    Type: Application
    Filed: May 8, 2014
    Publication date: August 28, 2014
    Applicants: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Raymond W. Sze, Omid Veiseh, James Olson, Mandana Veishe, Patrik Gabikian, S-Bahram Bahrami
  • COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HYPOXIC OR ISCHEMIC INJURY
    Publication number: 20140228302
    Abstract: Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.
    Type: Application
    Filed: February 5, 2014
    Publication date: August 14, 2014
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Fuqiang Ruan, Edward A. Winter, Thomas L. Deckwerth
  • METHOD OF MEASURING ADAPTIVE IMMUNITY
    Publication number: 20140221220
    Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.
    Type: Application
    Filed: April 14, 2014
    Publication date: August 7, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Harlan Saul Robins, Edus H. Warren, III, Christopher Scott Carlson
  • COMPOSITIONS AND METHODS TO MODULATE ANGIOGENESIS
    Publication number: 20140220161
    Abstract: The present invention provides methods of stimulating angiogenesis and the growth or migration of cells associated with angiogenesis, by contacting animals, tissues, or cells with sulfide, alone or in combination with nitric oxide. These methods may be used for a variety of purposes, including promoting wound healing, increasing blood flow, and for the treatment and prevention of diseases and disorders associated with decreased blood flow, including ischemic or hypoxic injury.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventor: Csaba Szabo
  • Method of Measuring Adaptive Immunity
    Publication number: 20140213463
    Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.
    Type: Application
    Filed: April 2, 2014
    Publication date: July 31, 2014
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Harlan S. Robins, Edus H. Warren, III, Christopher Scott Carlson
  • METHOD OF MEASURING ADAPTIVE IMMUNITY
    Publication number: 20140206548
    Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.
    Type: Application
    Filed: February 18, 2014
    Publication date: July 24, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Harlan Saul Robins, Edus H. Warren, III, Christopher Scott Carlson
  • METHOD OF MEASURING ADAPTIVE IMMUNITY
    Publication number: 20140206549
    Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.
    Type: Application
    Filed: February 18, 2014
    Publication date: July 24, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Harlan Saul Robins, Edus H. Warren, III, Christopher Scott Carlson
  • Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer
    Patent number: 8778310
    Abstract: A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: July 15, 2014
    Assignees: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Raymond W. Sze, Omid Veiseh, James M. Olson, Mandana Veiseh, Patrik Gabikian, S-Bahram Bahrami
  • Method of Measuring Adaptive Immunity
    Publication number: 20140194295
    Abstract: A method of measuring immunocompetence is described. This method provides a means for assessing the effects of diseases or conditions that compromise the immune system and of therapies aimed to reconstitute it. This method is based on quantifying T-cell diversity by calculating the number of diverse T-cell receptor (TCR) beta chain variable regions from blood cells.
    Type: Application
    Filed: December 3, 2013
    Publication date: July 10, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Harlan S. Robins, Edus H. Warren, III, Christopher Scott Carlson
  • METHODS FOR TREATING OR PREVENTING RADIOCONTRAST AGENT INDUCED KIDNEY INJURY
    Publication number: 20140193525
    Abstract: Methods for treating or preventing radiocontrast agent induced kidney injury in a mammal are disclosed, the methods comprising administering to the mammal a first effective amount of a chalcogenide composition prior to administering a radiocontrast agent to the mammal.
    Type: Application
    Filed: August 15, 2013
    Publication date: July 10, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Chienmin Su, Csaba Szabo
  • ENGINEERED TAL EFFECTOR PROTEINS WITH ENHANCED DNA TARGETING CAPACITY
    Publication number: 20140186957
    Abstract: The present invention provides compositions and methods for DNA targeting using TAL effectors and TAL effector based proteins, including but not limited to targeted gene regulation and targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides comprising a TAL effector or a TAL effector binding domain in combination with other domains, including but not limited to a cleavage domain. The TAL effector binding domain includes modifications that increase activity of the same and also remove the constraints that the DNA target sequence be preceded by a thymine.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 3, 2014
    Applicants: Fred Hutchinson Cancer Research Center, Iowa State University Research Foundation, Inc.
    Inventors: Adam Joseph Bogdanove, Barry Leonard Stoddard, Philip H. Bradley, Erin Lynn Doyle
  • Quantification of Adaptive Immune Cell Genomes in a Complex Mixture of Cells
    Publication number: 20140186848
    Abstract: Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in a tumor of tumor infiltrating lymphocytes (TIL), the relative presence of lymphocytes infiltrating a somatic tissue that is the target of an autoimmune disease, and the relative presence of lymphocytes infiltrating a transplanted organ.
    Type: Application
    Filed: March 6, 2014
    Publication date: July 3, 2014
    Applicants: Fred Hutchinson Cancer Research Center, Adaptive Biotechnologies Corporation
    Inventors: Harlan S. Robins, Robert J. Livingston, Jason H. Bielas
  • DRUG DISCOVERY METHODS AND PLATFORMS
    Publication number: 20140179560
    Abstract: Methods and systems for discovering drug candidates are disclosed. Methods and systems can include generating libraries of potential drug candidates (e.g., libraries of peptides) that can be screened to identify sub-libraries of potential drug candidates (e.g., sub-libraries of peptides) having selected pharmacological properties. Methods of making and using peptide libraries are also provided. D-amino acid chlorotoxins and D-amino acid chlorotoxin variants are also provided.
    Type: Application
    Filed: December 10, 2013
    Publication date: June 26, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: James Olson, Christopher Mehlin, Mark Stroud, Julian Simon, Colin Correnti, Patrick Paddison, Roland Strong, Damon May
  • NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS
    Publication number: 20140162360
    Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
    Type: Application
    Filed: February 11, 2014
    Publication date: June 12, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: S. Bahram Bahrami, Mandana Veiseh, James M. Olson
  • NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS
    Publication number: 20140162901
    Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
    Type: Application
    Filed: February 11, 2014
    Publication date: June 12, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: S. Bahram Bahrami, Mandana Veiseh, James M. Olson
  • METHODS AND COMPOSITIONS FOR IDENTIFYING INCREASED RISK OF DEVELOPING FRAGILE X-ASSOCIATED DISORDERS
    Publication number: 20140141439
    Abstract: The present invention provides compositions and methods of identifying a subject as having an increased risk of developing fragile X-associated tremor and ataxia syndrome (FXTAS) or identifying a subject having an increased risk of developing fragile X syndrome (FXS), comprising analyzing messenger RNA (mRNA) transcripts and/or translation products of the antisense gene ASFMR1.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 22, 2014
    Applicant: THE FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: STEPHEN J. TAPSCOTT, GALINA N. FILIPPOVA, PAULA D. LADD
  • HEPSIN INHIBITORS
    Publication number: 20140127127
    Abstract: Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.
    Type: Application
    Filed: January 16, 2014
    Publication date: May 8, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Valeri I. Vasioukhin, John R. Chevillet
  • COMBINATIONS OF NITRIC OXIDE AND SULFIDE AND METHODS OF USE AND MANUFACTURE THEREOF
    Publication number: 20140093588
    Abstract: The present invention provides methods of reducing the cytotoxic effects of nitric oxide and sulfides comprising coadministering nitric oxide with sulfide. In addition, the present invention provides novel pharmaceutical compositions comprising both nitric oxide and sulfide. The methods and compositions of the present invention may be used in the treatment or prevention of a variety of diseases and disorders, and also in the prevention of cell or tissue damage, including that resulting from ischemia or hypoxia.
    Type: Application
    Filed: March 28, 2013
    Publication date: April 3, 2014
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Csaba Szabo, Kevin James Tomaselli
  • Compounds, compositions and methods for treating or preventing hypoxic or ischemic injury
    Patent number: 8680151
    Abstract: Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: March 25, 2014
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Fuqiang Ruan, Edward A. Wintner, Thomas L. Deckwerth
  • Needle array assembly and method for delivering therapeutic agents
    Patent number: 8672887
    Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: March 18, 2014
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: S. Bahram Bahrami, Mandana Veiseh, James Olson