Patents Assigned to Fred Hutchinson Institute for Cancer Research
  • Isolated P27 protein, nucleic acid molecules encoding same, methods of identifying agents acting on same, and uses of said agents
    Patent number: 6635450
    Abstract: An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for producing p27 in cultured cells. in vitro assays for discovering agents which effect the activity of p27 are also provided. Methods of diagnosing and treating hypoproliferative and hyperproliferative disorders are provided.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: October 21, 2003
    Assignees: Fred Hutchinson Institute for Cancer Research, Sloan-Kettering Institute for Cancer Research
    Inventors: Joan Massague, James M. Roberts, Andrew Koff, Kornelia Polyak
  • Antibodies for detecting p27 protein
    Patent number: 6242575
    Abstract: The subject invention provides an isolated protein having an apparent molecular weight of about 27 kD and capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. The subject invention further provides an isolated antibody and a purified preparation of polyclonal and monoclonal antibodies which are specifically immunoreactive with a p27 protein. The subject invention further provides a kit for detecting a p27 protein.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: June 5, 2001
    Assignees: Fred Hutchinson Institute for Cancer Research, Sloan-Kettering Institute for Cancer Research
    Inventors: Joan Massague, James M. Roberts, Andrew Koff, Kornelia Polyak