Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
Type:
Grant
Filed:
August 19, 2019
Date of Patent:
April 4, 2023
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison, Melissa Hill-Drzewi
Abstract: The present disclosure relates to quinolin-4-one and 4(1H)-cinnolinone compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Type:
Application
Filed:
February 7, 2020
Publication date:
February 23, 2023
Applicant:
Frequency Therapeutics, Inc.
Inventors:
Bradley TAIT, Megan S. HARRISON, Will MCLEAN
Abstract: Provided herein are compound(s) for use in treating sensorineural hearing loss in a human patient, for example, hair cell regeneration agent(s) for use in treating sensorineural hearing loss in a human. Also provided are methods of treating sensorineural hearing loss in a human by administering certain compound(s), for example, hair cell regeneration agent(s).
Type:
Application
Filed:
April 8, 2020
Publication date:
June 9, 2022
Applicant:
Frequency Therapeutics, Inc.
Inventors:
Carl LEBEL, Jenna HERBY, Will MCLEAN, Ashley HINTON, Moraye BEAR, Christopher LOOSE
Abstract: The present invention provides methods for treating diseases and disorders of the ear with valproic acid compounds and Wnt agonists. The present invention further provides kits for the same.
Abstract: Provided are compositions and methods comprising an epigenetic agent and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
Type:
Application
Filed:
February 7, 2020
Publication date:
April 28, 2022
Applicant:
Frequency Therapeutics, Inc.
Inventors:
Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI, Bradley TAIT
Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
March 1, 2022
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will Mclean, Megan Harrison, Michael R. Jirousek
Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Type:
Grant
Filed:
January 4, 2019
Date of Patent:
November 2, 2021
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
Type:
Grant
Filed:
August 19, 2019
Date of Patent:
November 2, 2021
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison
Abstract: The present invention relates to 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Type:
Grant
Filed:
December 21, 2017
Date of Patent:
July 20, 2021
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Bradley Tait, Rajesh Manchanda, Will Mclean
Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Type:
Grant
Filed:
December 20, 2018
Date of Patent:
June 15, 2021
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 2-pyrimidinylaminoethylamino-2-pyridyl moiety having a Formula I and pharmaceutically acceptable salts thereof.
Type:
Application
Filed:
May 12, 2020
Publication date:
April 1, 2021
Applicant:
Frequency Therapeutics, Inc.
Inventors:
Christopher LOOSE, Will MCLEAN, Melissa HILL-DRZEWI
Abstract: The present invention relates to 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into tissue cells.
Type:
Grant
Filed:
December 22, 2017
Date of Patent:
August 20, 2019
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Bradley Tait, Rajesh Manchanda, Will McLean
Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 3-(pyridin-2-yl)-1H-indol-2-ol containing moiety having a Formula I: and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
March 5, 2019
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Melissa Hill-Drzewi
Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
February 26, 2019
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
February 12, 2019
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
July 10, 2018
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 3-(pyridin-2-yl)-1H-indol-2-ol containing moiety having a Formula I: and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
May 15, 2018
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Melissa Hill-Drzewi
Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a 1,2,3,4-tetrahydro-[1,4]diazepino[6,7, 1-hi]indole moiety having a Formula I and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
March 13, 2018
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Melissa Hill-Drzewi
Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a N-(1H-pyrazol-4-yl)-nicotinamide moiety having a Formula I: and pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
March 2, 2017
Date of Patent:
March 13, 2018
Assignee:
Frequency Therapeutics, Inc.
Inventors:
Christopher Loose, Will McLean, Melissa Hill-Drzewi