Abstract: A method that regulates supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. An extracorporeal blood treatment apparatus that includes a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

Abstract: The present invention relates to a system (100) for extracorporeal blood treatment comprising a first inlet (1) for introducing a bloodstream to be treated into the system (100), three blood treatment apparatus (A, D, G), as well as an outlet (2) for discharging a treated bloodstream from the system (100), wherein the system comprises an adsorber apparatus (A) and/or a plasma separator apparatus, a dialysis apparatus (D) and a gas exchange apparatus (G), and wherein the three blood treatment apparatus (A, D, G) are sequentially connected in series in a functional state of system (100) application between the inlet (1) and the outlet (2) of the system relative to a direction of blood flow of a bloodstream to be treated and can be consecutively perfused extracorporeally by a bloodstream to be treated.

Abstract: A method of operating an extracorporeal blood treatment system to infuse blood into a patient at an end of an extracorporeal blood treatment includes clamping an access line of an arterial line set. The method further includes, after clamping the access line, initiating an operation to generate negative pressure in the arterial line set. The method further includes, after generating the negative pressure in the arterial line set, unclamping the access line to draw fluid in the access line further into the arterial line set in a direction away from an end of the access line that is connectable to an arterial access of the patient. The method further includes initiating an operation of a fluid pump engaged with the arterial line set such that the fluid in the arterial line set is infused into the patient through a venous line set.

Abstract: The present invention relates to a dialysis machine having an extracorporeal blood system; a dialysis fluid system having a dialyzer; having a control unit, wherein the dialysis machine furthermore comprises a balancing chamber having two balancing chamber halves for a balanced infeed and draining of dialysis fluid to and from the dialyzer, wherein a line is provided through which the dialysis fluid is conducted to the balancing chamber, and wherein a mixing chamber is provided in which the fresh dialysis fluid or a component thereof is located and which is directly or indirectly connected to a de-airing line closable by a valve; wherein the dialysis machine has a control unit that is configured such that the control unit opens and closes the valve once, or a number of times, in the operating state of the special air separation of the dialysis machine when the balancing chamber half of the balancing chamber in fluid communication with the named line is in its high-pressure phase.

Abstract: The invention relates to a device having a two-component drip edge. One side of the drip edge is formed by a material having an attractive behavior with respect to a liquid and the opposite side of the drip edge is formed from a material having a repulsive behavior with respect to the liquid. This design yields an improved drip effect.

Abstract: The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflows of the first balancing chamber halves are in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow and the second outflows of the second balancing chamber halves are in fluid communication with a drain, wherein a third balancing chamber is provided that has two balancing chamber halves that are separated from one another by a movable wall, wherein each of the balancing chamber halves has a respective inflow and a respective outflow that are each provided with valves that are configured to close or open the respective inflow or outflow, wherein the two inflows are in fluid communication with a source of fresh dial

Abstract: The invention relates to a circuit arrangement for a protective-conductor connection to at least two fluid-conducting lines 11, 12, in particular to at least two fluid-conducting lines which are guided outwards from the interior of a housing 1 of a medico-technical device, in particular the housing of a blood treatment device. The circuit arrangement comprises a plurality of protection apparatuses 16A, 16B; 17A, 17B for electrical contacting which are designed such that an electrical connection to a fluid in the line can be produced using each protection apparatus for electrical contacting. In the circuit arrangement, at least two protection apparatuses 16A, 16B; 17A, 17B for electrical contacting are assigned to each fluid-conducting line 11, 12. As a result, two protective measures are taken for each fluid-conducting line.

Abstract: Methods for checking a connection between a compressed air outlet of a blood treatment apparatus and a pressure measuring line of an extracorporeal blood tubing set. The methods include providing a blood treatment apparatus having a compressed air line. A compressed air device is in fluid communication with the compressed air line for generating pressure within the compressed air line. A compressed air outlet is in fluid communication with both the compressed air line and an exterior of the blood treatment apparatus. The compressed air outlet is connectable with a pressure measuring line and a pressure sensor. The method also includes building up a pressure and an air flow in the compressed air line and/or at the compressed air outlet, measuring a pressure at the compressed air outlet or in the compressed air line, and evaluating an increase of the measured pressure.

Abstract: This disclosure relates to a method for determining a fluid balance between a first volume flow in a first section of a fluid circuit and a second volume flow of a second section of the fluid circuit. The method may also include adjusting, assuming or detecting a first temperature in the first section of the fluid circuit and a second temperature in the second section of the fluid circuit, or detecting a temperature difference between the first and the second sections. The method may also include detecting a second volume flow in a second section of the fluid circuit and forming a balance from at least the first volume flow and a corrected value of the second volume flow. The corrected value is determined from the detected second volume flow and the second temperature and/or the temperature difference.

Abstract: The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber of which each has at least two first and second balancing chamber halves separated from one another by a movable wall, wherein each first balancing chamber half is provided with a respective first inflow and with a respective first outflow, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflow of the first balancing chamber half is in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow, wherein the second outflows of the second balancing chamber halves are in fluid communication with one another so that consumed dialyzate can be transferred from a second balancing chamber half of one balancing chamber to a second balancing chamber half of the other balancing chamber

Abstract: The present invention relates to a dialysis machine having a dialyzate circuit and having a dialyzer, wherein the dialysis machine has an apparatus for identifying the dialyzer; wherein the apparatus has means for filling the dialyzer with fluid and has means for determining the filling amount of fluid that is filled into the dialyzer; and wherein the apparatus furthermore has means for determining the pressure that is characteristic for the pressure in the filled region of the dialyzer, wherein an evaluation device is provided that is configured to put the measured filling amount into relationship with the measured pressure and to compare it with a predefined characteristic curve or with a predefined characteristic value, with the evaluation device furthermore being configured to output a signal that depends on whether the relationship determined coincides with the predefined characteristic curve or with the predefined characteristic value.

Abstract: The present invention relates to an apparatus for providing liquid dialysis concentrate comprising a dialysis concentrate container for receiving the dialysis concentrate, wherein the dialysis concentrate container has an outflow and wherein the apparatus has a measurement device that is in fluid communication with the outflow and that is configured to determine the density or a property of the dialysis concentrate correlated with the density, with a shut-off element, in particular a valve, being arranged in the outflow by means of which the outflow can be selectively opened or closed.

Abstract: The present disclosure describes a kit for peritoneal dialysis that includes at least two bags. The kit also includes an overwrap for accommodating the at least two bags. At least one bag of the at least two bags forms at least a portion of the overwrap. According to the present disclosure, it is advantageously possible to reduce the material consumption of the overwrap, lower the cost of the kit, and reduce the amount of the disposable waste.

Abstract: The invention relates to a method and an automatic disinfection machine for the controlled disinfection of the skin of a patient comprising a treatment chamber for accommodating the body part with the skin to be disinfected; an electrically controllable disinfecting device for disinfecting the skin, a recording device for recording the disinfection of the skin in the form of disinfection data, a data processing control device for controlling the disinfecting device and the recording device. The control device is thereby designed to effect the disinfection of the skin by controlling the disinfecting device, record the disinfection of a skin section of the skin in the form of disinfection data by controlling the recording device.

Abstract: There is disclosed a preparation of extracellular vesicles derived from human liver stem cells, preferably from a non-oval human progenitor cell line that expresses hepatic cell markers, which is capable of reducing the senescence of a population of senescent cells, as measured in a SA-?-galactosidase-based cellular senescence assay. Also disclosed are therapeutic applications of the preparation of extracellular vesicles derived from human liver stem cells according to the invention. Therapeutic applications include the reduction of cellular senescence, e.g. in an vitro or ex vivo method, as well as the therapeutic treatment of diseases and conditions known to be related to ageing and cellular senescence, such as for example atherosclerosis, diabetes mellitus type 2, asthenia, and others.

Abstract: The present invention relates to an apparatus for performing peritoneal dialysis, the apparatus comprising means for delivering dialysis fluid to the peritoneal cavity of a patient, a measurement device for measuring the fluid pressure of the delivered dialysis fluid and/or the fluid pressure in the peritoneal cavity, i.e. the intraperitoneal pressure and/or any pressure related thereto, and a control unit operably connected to said means and the measurement device, wherein the control unit is configured to effect an inflow or outflow phase encompassing a series of fill-and-measurement or drain-and-measurement steps, each step comprising delivering a predetermined quantity of dialysis fluid to the peritoneal cavity or draining a predetermined quantity of dialysis fluid from the peritoneal cavity and subsequently measuring and recording a pressure value.

Abstract: The invention relates to a method and an apparatus for selecting a medical accessory for treatment of a patient. The method comprises at least one of the following method steps. A first method step of receiving a patient identifier identifying the patient to be treated. A second method step of determining a treatment identifier of the treatment to be performed which identifies the treatment to be performed on the patient. A third method step of comparing an accessory database containing data sets on at least two medical accessories for one or more patient treatments to an actual inventory of stocked medical accessories. A fourth method step of selecting a suitable medical accessory for a treatment to be performed on the patient by means of the accessory database and on the basis of at least the patient identifier, the treatment identifier and the actual inventory. A fifth method step of segregating the selected medical accessory.

Abstract: The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading.

Abstract: The present invention relates to a method of stabilizing a dialysis solution that includes calcium ions and bicarbonate ions, wherein a phosphate and/or an organic phosphate ester is added to the dialysis solution at a distance of time from its preparation.

Abstract: A peritoneal dialysis machine carries out of a peritoneal dialysis treatment having recurring cycles, the recurring cycles involving an inflow phase, a dwell period and a drainage phase for a dialysis fluid, wherein the peritoneal dialysis machine has a control unit and a measurement apparatus for determining the inflow rate and/or drainage rate of the dialysis fluid to and from a patient, wherein the control unit is configured to carry out a comparison between a time progression curve of the inflow rate and/or of the drainage rate determined by the measurement apparatus during the inflow phase and/or the drainage phase and a corresponding reference curve and to recognize on the basis of the comparison a disturbance in inflow and/or drainage of the dialysis fluid to and from the patient.