Abstract: The present invention relates to a prefunctionalized metallic nanoparticle (10) as a standardized basic building block of biofunctionalized nanoparticles (40), having a thiol-reactive metallic nanoparticle (12) that is prefunctionalized by a bifunctional molecule (20) that consists of an anchor component (22) and a short further-functionalization stub (24). Here, it is provided that the anchor component (22) comprises one or more dithiophosphate groups, and the short further-functionalization stub (24) is adapted for the attachment of a desired biofunctionalization (30) and is selected from the group consisting of i) an unmodified standardized oligonucleotide strand (26) having 2 to 18 bases for further-functionalization with biomolecules (30) having a terminal complementary strand (36) of the standardized oligonucleotide strand (26), and ii) a 2- to 18-base-long oligonucleotide strand (50; 60) that is modified with a terminal reactive group (52; 62) for biomolecules.
Type:
Grant
Filed:
January 27, 2017
Date of Patent:
January 18, 2022
Assignee:
FRIZ BIOCHEM GESELLSCHAFT FÜR BIOANALYTIK MBH
Abstract: The invention relates to a swab system, comprising a sample tube, which is closed at the front end and open at the rear end, and a swab. The swab has an elongated, tubular swab rod, wherein the swab rod is provided with a sample-gathering means at the front end of the swab rod and a gripping piece at the rear end of the swab rod. The gripping piece closes the rear, open end of the sample tube in an accurately fitting manner and is equipped with a closing cap for covering the gripping piece in a sealed manner. The gripping piece has the internal taper of a Luer connection, wherein the internal taper of the Luer connection has a fluid connection to the tubular swab rod.
Type:
Application
Filed:
September 21, 2012
Publication date:
September 25, 2014
Applicant:
FRIZ BIOCHEM GESELLSCHAFT FUR BIOANALYTIK MBH