Patents Assigned to Fructamine S.p.A.
  • Process for the purification of an intermediate
    Patent number: 5849953
    Abstract: This invention refers to a new process for the synthesis of (S)-N,N'-bis?(2-hydroxy-1-(hydroxymethyl)ethyl!-5-?(2-hydroxy-1-oxopropyl! amino!-2,4,6-triiodo-1,3-benzendicarboxamide, of formula (III), ##STR1## starting from 5-amino-2,4,6-triiodo-1,3-benzendicarboxylic acid dichloride characterized by a new step of chromatographic purification through resins of (S)-5-??2-(acetyloxy)-1-oxopropyl!amino!-2,4,6-triiodo-1,3-benzendicarboxy lic acid dichloride, which enables the direct conversion to the compound of formula (III), without preventive isolation.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: December 15, 1998
    Assignee: Fructamine S.p.A.
    Inventor: Nicola Desantis
  • Process for the preparation of a halosubstituted aromatic acid
    Patent number: 5763650
    Abstract: The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid, comprising the following steps:a) catalytic hydrogenation of 5-nitro-1,3-benzenedicarboxylic acid in neutral or basic environment, which gives an aqueous solution of 5-amino-1,3-benzenedicarboxylic acid sodium salt;b) direct iodination of the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution deriving from step a), without further purification, with a solution of ICl in HCl, being the 5-amino-1,3-benzenedicarboxylic acid sodium salt solution previously added with HCl and H.sub.2 SO.sub.4.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: June 9, 1998
    Assignee: Fructamine S.p.A.
    Inventors: Marina Mauro, Carlo Felice Viscardi, Massimo Gagna
  • Process for the preparation of a dicarboxylic acid di-chloride
    Patent number: 5672735
    Abstract: The present invention refers to a Process for the preparation of S-(-)-5-??2-(acetyloxy)-1-oxopropyl!amino!-2,4,6-triiodo-1,3-benzenedicarb oxylic acid dichloride of formula (I) comprising the reaction between S-(-)-?2-(acetyloxy)!propionic acid chloride and 5-amino-2,4,6-triiodo-, 1,3-benzenedicarboxylic acid dichloride, in an aprotic dipolar solvent and in presence of a halogenhydric acid.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: September 30, 1997
    Assignee: Fructamine S.p.A.
    Inventors: Marina Mauro, Carlo Felice Viscardi, Massimo Gatti, Nicola Desantis
  • Process for the preparation of a dicarboxylic acid dichloride
    Patent number: 5616795
    Abstract: The present invention refers to a process for the preparation of 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride, comprising the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride, in a solvent selected from the group consisting of: (C.sub.7 -C.sub.16) linear or branched hydrocarbons, (C.sub.7 -C.sub.8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butylacetate, diglyme (diethylenglycoledimethylether), and in the presence of a catalytic amount of a tertiary amine.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: April 1, 1997
    Assignee: Fructamine S.p.A.
    Inventors: Marina Mauro, Carlo F. Viscardi, Massimo Gagna