Abstract: The invention deals with the use of low temperature and low humidity conditions during the storage and shaping of “flash-dose” tablet compositions. The compositions may be rendered substantially non-amorphous before tablet formation.

Abstract: A chewing gum composition for instant and extended release breath freshening has a gum base, at least one wetting agent, at least one immediate release flavor ingredient, and at least on encapsulation. The encapsulations include flavor encapsulations, metallic ion encapsulations, and organic substance encapsulations.

Abstract: The present invention is a unique process and apparatus for making a new matrix material called a shearform matrix which results in transformation of the morphology of a feedstock. The process is characterized by increasing the temperature of a nonsolubilized feedstock carrier to a point where it will undergo internal flow, followed by upwardly ejecting a stream of the feedstock and then subjecting it to disruptive fluid shear force which separates it into separate parts or masses which have a transformed morphology. The shearform matrix may include other ingredients such as oleaginous material and actives.

Abstract: The invention relates to compositions useful for making taste-masked oral dosage forms which can be easily processed and which disintegrate rapidly when placed in the mouth. The compositions include coated liquiflash particles and shearform floss particles. Tablets are preferred dosage forms.

Abstract: The treatment of for arresting the destructive effects of proteolytic enzymes produced by a host infecting organism, such as "flesh eating bacteria", is carried out using therapy with includes the administration of one or more protease inhibitors.

Abstract: The present invention is a new mesomorphic polycrystallite product and a process for making the same. In the present invention amorphous sugar is transformed to a mesomorphic product having polycrystallites therein by a completely anhydrous process rather than by hydrating and then dehydrating the sugar. The product of the present invention is unique in shape and size, and possesses a high degree of uniformity. The properties of the polycrystallite make it possible to replace some or all of the fat in comestibles such as frostings and fillings and to provide fondants of extraordinarily fine grain.

Abstract: A method of producing a solid thermoplastic-containing matrix by flash flow processing thermoplastic polymers as well as the products produced by such method is provided. The method involves subjecting a feedstock of a thermoplastic polymer to flash flow melt spin processing at a temperature of about 200-430.degree. F. and shear imposed by centrifugal force from an operating speed of about 3600-3800 rpm. The matrix thus prepared is in the form of a floss, fiber, flake, filament, ribbon, spicule and mixtures thereof A guest material such as a dye, a fragrance, a comestible, an oil, a photographic reducer and developer, an organism, an antioxidant and a medicament may further be incorporated into the feedstock prior to processing.

Abstract: A spinner head provides for the production of melt-spun product. The spinner head includes a base and a cover spaced from the base. A plurality of discrete spaced apart elongate heating elements are positioned between the base and the cover and define a chamber for accommodating feedstock material therein. An elongate generally annular housing having plural circumferentially spaced cylindrical passages extending therethrough is positionable over the heating elements. The housing defines a plurality of circumferentially spaced fins projecting radially inward. Each of the fins have tapered sidewalls which generally converge as the fin extends radially inward. The sidewalls of adjacent fins cooperate to define longitudinal radially-directed slots between the cylindrical passages so as to permit passage of the feedstock material therethrough.

Abstract: The thermoforming of compositions containing active agents is carried out by processing compositions containing certain fatty esters in combination.

Abstract: Microspheres which disintegrate quickly in water are composed of bio-affecting agent(s), disintegrant(s) and spheronization aid(s). The microspheres, which may have taste-masking coatings, are useful in making comestible units, such as pharmaceutical dosage forms.

Abstract: The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.

Abstract: A dry powder formulation of antibiotic and .beta.-lactam inhibitor is provided which is suitable for use in a liquid suspension.

Abstract: A single dose device for delivering an active substance via the nostrils or mouth is portable, lightweight, compact and easily hand-held.

Abstract: The invention relates to compositions useful for making tablets which can be formed using conventional tableting machines and which disintegrate rapidly in the mouth with optional chewing. The compositions typically include shearform matrices which have been recrystallized using crystallization promoters.

Abstract: The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.

Abstract: The invention deals with microspheres which are useful in pharmaceutical dosage forms. The microspheres contain active agents and solubilizing agents which have been processed via liquiflash techniques.

Abstract: A self-binding, glycerine-free tablettable composition has a saccharide carrier and the sugar alcohols sorbitol and xylitol.

Abstract: A beverage composition has a source of fiber, as well as one or more additional nutrients. The composition is in the form of a shearform matrix as a result of flash-flow processing. The beverage composition is highly storage stable.

Abstract: A remotely operable stent is disclosed which is radially expandable and contractable along the longitudinal length of the stent. Once the stent is positioned within a body lumen requiring radial support, an actuator and expansion/contraction element increase the radial dimension of the stent along the stent's longitudinal length to provide such support. The stent is remotely operable in vivo using a remote activation system such that the radial dimension of the stent can be changed without the need to re-enter the body lumen.

Abstract: A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.