Abstract: An agent for improvement of cerebral metabolism, containing as active ingredient a glucose ester derivative presented by the formula: ##STR1## and wherein the anomeric substitute in the formula is either .alpha. or .beta.; R to R.sub.4, each represents H atom, a straight or branched acyl or a ring containing acyl having 2 to 8 carbon atoms, provided that at least one of said R to R.sub.4 is the acyl group.The present agent is effective for the treatment of cerebral disorders resulting from hypoglycemic shock, the reduced capacity of active glucose trasport through the blood-brain barrier, and senile dementia or senile movement functional disorders.