Abstract: According to one embodiment, a medical image diagnostic apparatus includes a storage unit, a blood flow information generation unit and a blood flow inhibition index generation unit. The storage unit stores volume data or data of a series of images regarding an organ of an object. The blood flow information generation unit generates, based on the volume data or the data of the series of images, first blood flow information of a first region and second blood flow information of a second region different from the first region. The blood flow inhibition index generation unit generates, based on the first blood flow information and the second blood flow information, a blood flow inhibition index representing a degree of inhibition of a blood flow in a blood vessel regarding the first region or the second region.

Abstract: According to one embodiment, a medical image processing apparatus includes an image acquisition part and a data processing part. The image acquisition part is configured to obtain X-ray image data of an object including not less than three phantoms whose X-ray absorption factors are different from each other. The data processing part is configured to generate corrected X-ray image data of the object by correcting the obtained X-ray image data or other X-ray image data. The obtained X-ray image data or the other X-ray image data are corrected using a nonlinear function obtained based on pixel values of the obtained X-ray image data. The pixel values correspond to the phantoms.

Abstract: It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.

Abstract: Provided is a method of providing an effective means as a countermeasure for handling a pandemic of an influenza virus. The resistance to a type A influenza virus is determined using, as an indicator, the presence or otherwise of antibodies using the VH1-69 gene in a biological sample originating from a subject.

Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.

Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.

Abstract: An image processing apparatus according to an embodiment includes an acquiring unit, a correcting unit, and a perfusion image creating unit. The acquiring unit obtains a pixel value of a myocardium tissue and an arterial blood before a contrast agent injected in a second contrast examination arrives at a cardiac of a subject when myocardium perfusion data is created, by performing the second contrast examination that captures a second medical image group including the cardiac of the subject who is given an injection of a contrast agent again after a first contrast examination that captures a first medical image group. The correcting unit corrects contrast agent concentrations of an arterial blood and a myocardium tissue in the second medical image group using acquired each pixel value. The perfusion image creating unit computes the myocardium perfusion data in the second contrast examination based on the corrected contrast agent concentrations.

Abstract: It is an object of the present invention to provide a novel antibody having a high binding activity and a high neutralizing activity on influenza viruses. The present invention provides an antibody, which neutralizes H1 influenza virus and/or H5 influenza virus, wherein the antibody has a heavy chain variable region having CDRs consisting of a defined heavy chain first complementarity-determining region (VH CDR1), a defined heavy chain second complementarity-determining region (VH CDR2) and a defined heavy chain third complementarity-determining region (VH CDR3), and a light chain variable region having CDRs consisting of a defined light chain second complementarity-determining region (VL CDR2) and a defined light chain third complementarity-determining region (VL CDR3).

Abstract: It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane and inhibits the adhesion of the ITGA6B4 complex to laminin, so as to inhibit adhesion of cancer cells to a bone marrow niche, and which is also capable of remarkably enhancing the effects of an anticancer agent on an anticancer agent resistant strain. The present invention provides an antibody against integrin A6B4, wherein the antibody specifically recognizes a human integrin A6B4 complex and inhibits intercellular adhesion.

Abstract: To provide a method for detecting cellular DNA damage by specifically recognizing molecules responsive to DNA strand breaks. A method for detecting DNA damage in cells, which comprises administering in vivo, to cells, an antibody against a cell membrane surface antigen that is expressed in cells undergoing DNA strand breaks to a greater extent than in cells not undergoing DNA strand breaks in an environment that causes DNA damage, and analyzing the expression status of the cell membrane surface antigen.

Abstract: According to one embodiment, a medical image processing apparatus includes an image acquisition part and a data processing part. The image acquisition part is configured to obtain X-ray image data of an object including not less than three phantoms whose X-ray absorption factors are different from each other. The data processing part is configured to generate corrected X-ray image data of the object by correcting the obtained X-ray image data or other X-ray image data. The obtained X-ray image data or the other X-ray image data are corrected using a nonlinear function obtained based on pixel values of the obtained X-ray image data. The pixel values correspond to the phantoms.

Abstract: An object is to provide a material capable of removing A? from a body fluid efficiently and use of the material, which are developed for the purpose of establishing a therapeutic or preventive method for Alzheimer's disease. Provided is an amyloid ? protein remover, containing a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 18 carbon atoms on the surface thereof.

Abstract: An image processing apparatus according to the present embodiment includes a correcting unit. The correcting unit identifies, based on an observation value of a residual contrast material component that is injected to a subject before a predetermined timing and remains in the subject, the residual contrast material component and a new contrast material component that is newly injected to the subject after the predetermined timing regarding a contrast material component that is included in an image, and corrects an observation value of the contrast material component included in the image.

Abstract: According to one embodiment, a medical image diagnostic apparatus includes a storage unit, a blood flow information generation unit and a blood flow inhibition index generation unit. The storage unit stores volume data or data of a series of images regarding an organ of an object. The blood flow information generation unit generates, based on the volume data or the data of the series of images, first blood flow information of a first region and second blood flow information of a second region different from the first region. The blood flow inhibition index generation unit generates, based on the first blood flow information and the second blood flow information, a blood flow inhibition index representing a degree of inhibition of a blood flow in a blood vessel regarding the first region or the second region.

Abstract: The present invention relates to an isolated antibody against HER1, an isolated antibody against CD147, an isolated antibody against CD73, and an isolated antibody against EpCAM; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies. The invention further relates to transformants comprising said nucleic acids or vectors.

Abstract: Antibodies (Abs) play roles in protection against influenza. Neutralizing Abs either inhibit the binding of hemagglutinin (HA) to cellular receptors or prevent the conformational change of HA induced by low pH. The former Ab binds to the regions near the sialic acid-binding pocket on the globular head formed by HA1 and generally shows narrow strain specificity. The latter Ab binds to the stem region formed mainly by HA2 and shows broad strain specificity. We isolated a broadly neutralizing Ab against H3N2 viruses. X-ray analysis of the HA/Ab complex indicated that the Ab binds to the valley formed by two neighboring HA monomers at the side of the globular head. The Ab shows neutralizing activity by preventing the conformational change of HA induced at low pH.

Abstract: An object is to provide a material capable of removing A? from a body fluid efficiently and use of the material, which are developed for the purpose of establishing a therapeutic or preventive method for Alzheimer's disease. Provided is an amyloid ? protein remover, containing a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 18 carbon atoms on the surface thereof.

Abstract: To provide a method for detecting cellular DNA damage by specifically recognizing molecules responsive to DNA strand breaks. A method for detecting DNA damage in cells, which comprises administering in vivo, to cells, an antibody against a cell membrane surface antigen that is expressed in cells undergoing DNA strand breaks to a greater extent than in cells not undergoing DNA strand breaks in an environment that causes DNA damage, and analyzing the expression status of the cell membrane surface antigen.

Abstract: Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.

Abstract: An object is to provide a material capable of removing A? from a body fluid efficiently and use of the material, which are developed for the purpose of establishing a therapeutic or preventive method for Alzheimer's disease. Provided is an amyloid ? protein remover, containing a carrier made of any one material selected from the group consisting of cellulose, silica, polyvinyl alcohol, and activated carbon, wherein the carrier does not have an alkyl chain on the surface thereof or has an alkyl chain having 1 to 18 carbon atoms on the surface thereof.