Abstract: A cannula guide device that can provide a secure and safe transfusion treatment is disclosed, comprising a cannula assembly and a needle assembly. The cannula assembly includes a cannula and a cannula holder, and the needle assembly includes a guide needle and a needle holder. The cannula guide device is characterized in that a rotary cannula arrangement is provided to steadily send the cannula relative to the guide needle toward a patient without generating a repulsive force on the needle holder to avoid pulling out the guide needle accidentally.