Patents Assigned to Fumapharm AG
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Patent number: 7320999Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.Type: GrantFiled: July 17, 2002Date of Patent: January 22, 2008Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Patent number: 7157423Abstract: Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24 alkyl radical, a phenyl radical or C6-10 aralkyl radical and R4 is a side chain of a natural or synthetic amino acid and R2 represents a D- or L-amino acid radical —NH—CHR5—COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.Type: GrantFiled: January 8, 2002Date of Patent: January 2, 2007Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Publication number: 20060205659Abstract: Fumaric acid amides of the general formula (I) wherein R1 represents OR3 or a D- or L-amino acid radical —NH—CHR4—COOH bonded via an amide bond, wherein R3 is hydrogen, a straight-chained or branched, optionally substituted C1-24 alkyl radical, a phenyl radical or C6-10 aralkyl radical and R4 is a side chain of a natural or synthetic amino acid and R2 represents a D- or L-amino acid radical —NH—CHR5—COOH bonded via an amide bond or a peptide radical comprising 2 to 100 amino acids bonded via an amide bond, wherein R5 is a side chain of a natural or synthetic amino acid, are used for preparing a drug (1) for the therapy of an autoimmune disease; (2) for use in transplantation medicine; (3) for the therapy of mitochondrial diseases; or (4) for the therapy of NF-kappaB mediated diseases.Type: ApplicationFiled: May 31, 2006Publication date: September 14, 2006Applicant: FUMAPHARM AGInventors: Rajendra Joshi, Hans-Peter Strebel
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Patent number: 6858750Abstract: The present invention relates to the use of individual fumaric acid derivatives or mixtures thereof for preparing a pharmaceutical composition for treating mitochondrial diseases, especially for treating Parkinson's syndrome, Alzheimer's disease, Chorea Huntington disease, retinopathia pigmentosa and mitochondrial encephalomyopathy. Preferably, the fumaric acid derivative(s) is/are those selected from the group consisting of fumaric acid dialkyl esters or fumaric acid monoalkyl esters in the form of the free acid or a salt thereof.Type: GrantFiled: December 11, 2000Date of Patent: February 22, 2005Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Patent number: 6509376Abstract: The present invention relates to the use of certain dialkyl fumarates for the preparation of pharmaceutical preparations for use in transplantation medicine or for the therapy of autoimmune diseases and said compositions in the form of micro-tablets or pellets. For this purpose, the dialkyl fumarates may also be used in combination with conventional preparations used in transplantation medicine and immunosuppressive agents, especially cyclosporines.Type: GrantFiled: May 10, 2001Date of Patent: January 21, 2003Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Patent number: 6436992Abstract: Disclosed is a method of treating auto-immune diseases by the administration of certain fumaric acid monoalkyl esters as salts or free acids thereof either alone or in combination with a dialkyl fumarate.Type: GrantFiled: July 8, 1999Date of Patent: August 20, 2002Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans Peter Strebel
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Patent number: 6359003Abstract: The invention relates to the use of certain fumaric acid monoalkyl esters as salts or a free acid either alone or in combination with a dialkyl fumarate for producing pharmaceutical preparations for use in transplantation medicine, especially for treating, alleviating or suppressing host-versus-graft reactions. For this purpose, the fumaric acid monoalkyl esters may be used in combination with preparations conventionally used in transplantation medicine and immuno suppressives, especially such as cyclosporines.Type: GrantFiled: December 8, 2000Date of Patent: March 19, 2002Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Patent number: 6355676Abstract: The present invention relates to the use of one or more salts of fumaric acid monoalkyl esters of the general formula optionally in admixture with dialkyl fumarate of the formula wherein A is a bivalent cation from the series consisting of Ca, Mg, Zn or Fe or a monovalent cation from the series Li, Na or K, respectively, and n denotes the numeral 1 or 2 depending on the type of cation, and, optionally, commonly used pharmaceutical excipients and vehicles for preparing a pharmaceutical composition in the form of micro-tablets or micro-pellets for the treatment of psoriatic arthritis, neurodermatitis, psoriasis and enteritis regionalis Crohn.Type: GrantFiled: January 17, 2001Date of Patent: March 12, 2002Assignee: Fumapharm AGInventors: Rajendra Kumar Joshi, Hans-Peter Strebel
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Patent number: 6277882Abstract: The use of one or several alkyl hydrogen fumarates of the general formula wherein R is a C1-5 alkyl, optionally in admixture with dialkyl fumarate of the formula and optionally customary pharmaceutical excipients and carriers for preparing a pharmaceutical composition in the form of micro-tablets or micro-pellets for treating psoriasis, psoriatic arthritis, neurodermatitis and enteritis regionalis Crohn.Type: GrantFiled: September 27, 1999Date of Patent: August 21, 2001Assignee: Fumapharm AGInventors: Rajendra K. Joshi, Hans-Peter Strebel