Abstract: The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one brain area identified as processing nociceptive pain signals. The force-regulatable device acts to alter the nociceptive pain signals in a brain area to alleviate nociceptive pain.

Abstract: The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one brain area identified as processing nociceptive pain signals. The force-regulatable device acts to alter the nociceptive pain signals in a brain area to alleviate nociceptive pain.

Abstract: A method of selectively inhibiting or driving neural discharge or activity in or from a specific brain area One embodiment of a system and/or method directed toward affecting neurologic function may apply conditioning stimuli to a set of target neural populations. The conditioning stimuli are intentionally timed to occur within an inhibitory time domain or a facilitatory time domain relative to intrinsic neural activity associated with a target neural population. The application of a conditioning stimulus within an inhibitory or facilitatory time domain relative to the occurrence of an intrinsic neural discharge may respectively diminish or enhance an outcome associated with the neural discharge. In one embodiment, conditioning stimuli may be produced by a pulse generator coupled to an electrode that is implanted relative to the location of a target neural population.

Abstract: The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one brain area identified as processing nociceptive pain signals. The force-regulatable device acts to alter the nociceptive pain signals in a brain area to alleviate nociceptive pain.

Abstract: A brain stimulation lead such as a deep brain stimulation (DBS) lead is provided, which lead can also be used to create lesions safely and effectively due to inclusion of temperature sensing. The generating of radio-frequency (RF) lesions via a brain stimulation lead provides a new treatment option, for instance, when hardware-related or other complications necessitate lead removal. An existing implanted DBS lead was used to create lesions in the thalamus and subthalamus of patients with movement disorders. Various brain stimulation leads with temperature sensors are described. Various methods are disclosed, including creation of a lesion with a brain stimulation lead while sensing temperature with a sensor implanted as part of the lead or with a noninvasive sensing device. Another method includes creating a graduated lesion with a brain stimulation lead of the invention or with a chronic lesioning lead.

Abstract: The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat an affective disorder, such as depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Abstract: The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat a cognitive impairment and/or disorder. More particularly, the method comprises surgically implanting an electrode and/or catheter that is in communication with a predetermined site which is coupled to a pulse generating source and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the cognitive disorder and/or enhancing the cognitive ability.

Abstract: The present invention relates to inhibitors of BAG and uses thereof, such as to inhibit cell loss, inhibit parkin sequestration, and/or inhibit formation of protein aggregates. More specifically, the present invention relates to BAG inhibitors used to inhibit neurodegeneration and to treat a neurodegenerative disease, such as Parkinson's disease.