Patents Assigned to Fundação de Amparo a Pesquisa Do Estado de São Paulo
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Patent number: 11147293Abstract: A process for obtaining an increase in the concentration and/or production of milk protein and/or improving reproductive performance. The process includes administering to a mammal a composition including at least one unsaturated fatty acid, or a derivative thereof, and at least one feed supplement, wherein the combination is administered in an amount such that the mammal absorbs 1 g to 95 g of the at least one unsaturated fatty acid, or the derivative thereof, per day.Type: GrantFiled: July 18, 2008Date of Patent: October 19, 2021Assignee: Fundacao De Amparo A Pesquisa Do Estado De Sao PauloInventors: Dante Pazzanese Duarte Lanna, Mark A. McGuire, Sergio Raposo de Medeiros, Dimas Estrasulas de Oliveira, Luis Januario M. Aroeira
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Patent number: 10626459Abstract: The present invention relates to a method and a kit for the identification of animals having greater potential for desirable characteristics of meat quality, rib eye area (REA), weaning weight and 18-month weight by means of the analysis of specific markers. The invention also refers to a method and a kit for the early identification of fat deposition in bovines.Type: GrantFiled: September 15, 2010Date of Patent: April 21, 2020Assignees: EMPRESA BRASILEIRA DE PESQUISA ACROPECUARIA—EMBRAPA, FUNDACAO UNIVERSIDADE FEDERAL DE SAO CARLOS—UFSCar, FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO-FAPESPInventors: Luciana Correia de Almeida Regitano, Gisele Batista Veneroni, Polyana Cristine Tizioto
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Patent number: 9090702Abstract: Modern sugarcane cultivars are complex hybrids resulting from crosses among several species of the Saccharum genus. Traditional breeding methods have been extensively employed in different countries along the past decades to develop varieties with increased sucrose yield, and resistant to plagues and diseases. Conventional varietal improvement is, however, limited by the narrow pool of suitable markers. In this sense, molecular genetics is seen as a promising tool to assist in the process of molecular marker identification. The present invention concerns the identification of 348 genes associated with sucrose content in sugarcane plants. The genes were found to be differentially expressed when high sucrose and low sucrose plants and populations of plants were compared and/or when high and low sucrose internodes were compared. The expression data was obtained using cDNA microarray and quantitative PCR technologies.Type: GrantFiled: March 23, 2011Date of Patent: July 28, 2015Assignees: UNIVERSIDADE DE SAO PAULO-USP., UNIVERSIDADE ESTADUAL DE CAMPINAS-UNICAMP., FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO-FAPESP., CENTRO DE TECNOLOGIA CANAVIEIRA, CENTRAL DE ALCOOL LUCELIA LTDA.Inventors: Glaucia Mendes Souza, Flavia Stal Papini-Terzi, Flavia Riso Rocha, Alessandro Jaquiel Waclawovsky, Ricardo Zorzetto Nicollielo Vêncio, Josélia Oliveira Marques, Juliana de Maria Felix, Marcelo Menossi Teixeira, Marcos Buckeridge, Amanda Pereira de Souza, Eugênio César Ulian
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Patent number: 8747325Abstract: The invention application presents a fast, efficient, reproductive alternative of a non-invasive method for diagnosing the severity of heart failure based on a specific biomarker. An additional object of the present invention is a collector device for the biomarker from exhaled breath that is portable, simple, low cost and does not need to run on electric power. This invention advantageously permits the replacement of invasive diagnosis methods, favoring the patient's comfort in addition to the agility and speed of medical attention at hospitals, and may become a standard method for all suspected cases of circulatory disease and heart failure and, more specifically, decompensated heart failure.Type: GrantFiled: July 16, 2010Date of Patent: June 10, 2014Assignees: Fundacao de Amparo A Pesquisa Do Estado De Sao Paulo (FAPESP), Universidade De Sao Paulo (USP)Inventors: Fernando Bacal, Fabiana Goulart Marcondes Braga, Ivano Gebhardt Rolf Gutz, Guilherme Lopes Batista
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Patent number: 8642258Abstract: The present invention relates to a product named “immunogenical complex”, which comprises an adjuvant characterized by solid particles of highly ordinated nanostructured mesoporous silica, preferably, SBA-15 Silica, and vaccinal antigens of several natures, encapsulated in the referred to adjuvants. The immunogenical complex of the present invention allows the presentation of the antigens that compose it to lymphocytes, in a safe, gradual and extended way, which leads to a more efficient immunological memory, increases the immunogenicity of the antigen and improves the production of antibodies. This ensures an efficient immunological protection with fewer amounts of antigens and/or less repetitions of vaccinal doses. In addition, the characteristics of the immunogenical complex of the present invention promotes effective immunity induction, homogeneous in “god and bad respondent” individuals.Type: GrantFiled: September 12, 2006Date of Patent: February 4, 2014Assignees: Cristalia Produtos Quimicos Farmaceuticos Ltda., Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FapespInventors: Ogari Pacheco, Osvaldo Augusto Sant'Anna, Lucildes Mercure, Jivaldo Matos, Márcia Fantini
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Patent number: 8338582Abstract: The present invention refers to new epitopes recognized by CD4+ T-lymphocytes. In addition, the present invention refers to the uses of such epitopes and their combinations, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to a composition comprising said epitopes and the uses of said composition, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to anti-HIV-1 prophylactic vaccines and therapeutic vaccines. Furthermore, the present invention refers to a method for the identification of epitopes and methods for treating or preventing an infection caused by the HIV-1 virus.Type: GrantFiled: March 5, 2008Date of Patent: December 25, 2012Assignees: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Fundacao Zerbini, Universidade de Sao Paulo-USPInventors: Edecio Cunha Neto, Jorge Elias Kalil Filho, Simone Goncalves Da Fonseca
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Patent number: 8304382Abstract: The present invention refers to synthetic, cyclic peptides containing a sequence of 13 L-amino acids in their primary structure which present anti-inflammatory and antiallergic activities, useful for the treatment of acute or chronic inflammation and/or allergies, being particularly useful for the treatment of acute or chronic allergic asthma. The invention also describes a pharmaceutical composition containing said peptides, its use and a method to treat or prevent acute and/or chronic inflammatory and/or allergic disorders.Type: GrantFiled: July 19, 2007Date of Patent: November 6, 2012Assignees: Cristalia Productos Quimicos Farmaceuticos Ltda., Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESPInventors: Mônica Ferreira, Carla Silva, Daniel Pimenta, Fernanda Portaro, Katia Conceição, Marilene Demasi
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Patent number: 8241391Abstract: A process for the treatment of loads or residues of non-ferrous metals and their alloys includes the steps of loading of scraps or dross to be processed and heating the load and melting the metal. The process additionally includes revolving the heated load, tapping the molten metal and emptying a cavity of the furnace. Heating of the load or residues to a temperature above the melting temperature of the metal or non-ferrous alloy to be recovered is carried out by a free burning convective arc which is independent from the supply of external gas to the process, and which may dispense with the use of melting salts.Type: GrantFiled: May 5, 2011Date of Patent: August 14, 2012Assignees: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP, Instituto de Pesquisa Technologicas do est, S. Paulo S/A-IPTInventors: Antonio Carlos da Cruz, Oskar Wessel Bender
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Publication number: 20120079621Abstract: Modern sugarcane cultivars are complex hybrids resulting from crosses among several species of the Saccharum genus. Traditional breeding methods have been extensively employed in different countries along the past decades to develop varieties with increased sucrose yield, and resistant to plagues and diseases. Conventional varietal improvement is, however, limited by the narrow pool of suitable markers. In this sense, molecular genetics is seen as a promising tool to assist in the process of molecular marker identification. The present invention concerns the identification of 348 genes associated with sucrose content in sugarcane plants. The genes were found to be differentially expressed when high sucrose and low sucrose plants and populations of plants were compared and/or when high and low sucrose internodes were compared. The expression data was obtained using cDNA microarray and quantitative PCR technologies.Type: ApplicationFiled: March 23, 2011Publication date: March 29, 2012Applicants: UNIVERSIDADE DE SAO PAULO--USP., UNIVERSIDADE ESTADUAL DE CAMPINAS -- UNICAMP., CENTRAL DE ALCOOL LUCELIA LTDA., CENTRO DE TECNOLOGIA CANAVIEIRA, FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO -- FAPESP.Inventors: Gl+e,acu a+ee ucia Mendes SOUZA, Fl+e,acu a+ee via Stal Papini-Terzi, Fl+e,acu a+ee via Riso Rocha, Alessandro Jaquiel Waclawovsky, Ricardo Zorzetto Nicollielo Vencio, Jos+e,acu e+ee lia Oliveira Marques, Juliana de Maria Felix, Marcelo Menossi Teixeira, Marcos Buckeridge, Amanda Pereira de Souza, Eug+e,cir e+ee nio C+e,acu e+ee sar Ulian
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Publication number: 20120053117Abstract: The present invention relates to the use of serpentine receptors existent in parasites of genus Plasmodium for treating malaria.Type: ApplicationFiled: October 2, 2009Publication date: March 1, 2012Applicants: Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo- FAPESP, Universidade de Sao Paulo-USPInventors: Célia Regina da Silva Garcia, Bettina Malnic, Luciana Madeira da Silva, Pedro Alexandre Favoretto Galante
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Publication number: 20110203413Abstract: A process for the treatment of loads or residues of non-ferrous metals and their alloys includes the steps of loading of scraps or dross to be processed and heating the load and melting the metal. The process additionally includes revolving the heated load, tapping the molten metal and emptying a cavity of the furnace. Heating of the load or residues to a temperature above the melting temperature of the metal or non-ferrous alloy to be recovered is carried out by means of a free burning convective arc which is independent from the supply of external gas to the process, and which may dispense with the use of melting salts.Type: ApplicationFiled: May 5, 2011Publication date: August 25, 2011Applicants: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - Fapesp, Instituto de Pesquisa Tecnologicas do Est. S. Paulo S/A - IPTInventors: Antônio Carlos da CRUZ, Oskar Wessel BENDER
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Publication number: 20110172975Abstract: The present invention relates to a method that uses error-coding codes for validating polymorphisms and mutations/alterations in a DNA sequence which encodes a polypeptide sequence. The present invention also relates to a digital communication system for carrying out the method, employing a model for the biological coding system which resembles the most efficient digital communication. The method and digital communication system may be useful for the predictive analysis of diseases originated by mutations or polymorphisms in genes.Type: ApplicationFiled: August 19, 2010Publication date: July 14, 2011Applicants: UNIVERSITY OF SAO PAULO, STATE UNIVERSITY OF CAMPINAS, FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULOInventors: Marcio de Castro SILVA FILHO, Reginaldo PALAZZO, JR., Andrea Santos LEITE DA ROCHA, Luzinete Cristina BONANI DE FARIA, Joao Henrique KLEINSCHMIDT
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Patent number: 7935728Abstract: The invention relates to cyclopalladated compounds containing bis-diphenylphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopeptidase families, involved in the development and metastases of malignant tumors, e.g. of the thyroid. An exemplary compound is shown in the figure. The compounds are able to modulate the immunological system due to their action on the enzymes and their interaction with DNA molecules.Type: GrantFiled: July 13, 2007Date of Patent: May 3, 2011Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao PauloInventors: Antonio Carlos Fávero Caires, Claudia Bincoletto Trindade, Ivarne Luis dos Santos Tersariol
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Patent number: 7754186Abstract: The invention concerns a process for the extraction of acid or basic oxides contained in a vegetal matter, more specifically it concerns the extraction of silica from rice husks. The invention also concerns pure oxides extracted from vegetal matter. The invention also concerns the process for the extraction of carbon-rich oxide compositions from vegetal matter, and compositions obtained through said process.Type: GrantFiled: April 21, 2008Date of Patent: July 13, 2010Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao PauloInventors: Milton F. De Souza, Paulo Dos Santos Batista, Jefferson B. L. Liborio
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Patent number: 7732664Abstract: Modern sugarcane cultivars are complex hybrids resulting from crosses among several species of the Saccharum genus. Traditional breeding methods have been extensively employed in different countries along the past decades to develop varieties with increased sucrose yield, and resistant to plagues and diseases. Conventional varietal improvement is, however, limited by the narrow pool of suitable markers. In this sense, molecular genetics is seen as a promising tool to assist in the process of molecular marker identification. The present invention concerns the identification of 348 genes associated with sucrose content in sugarcane plants. The genes were found to be differentially expressed when high sucrose and low sucrose plants and populations of plants were compared and/or when high and low sucrose internodes were compared. The expression data was obtained using cDNA microarray and quantitative PCR technologies.Type: GrantFiled: March 8, 2007Date of Patent: June 8, 2010Assignees: Universidade de Sao Paulo - USP., Universidade Estadual de Campinas - Unicamp., Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - Fapesp., Centro de Tecnologia Canavieira, Central de Alcool Lucelia Ltda.Inventors: Glaucia Mendes Souza, Flavia Stal Papini-Terzi, Flavia Riso Rocha, Alessandro Jaquiel Waclawovsky, Ricardo Zorzetto Nicollielo Vencio, Josélia Oliveira Marques, Juliana de Maria Felix, Marcelo Menossi Teixeira, Marcos Buckeridge, Amanda Pereira de Souza, Eugênio César Ulian
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Patent number: 7700195Abstract: A cutting tool and process for the formation thereof. The cutting tool comprises a basic body (1) presenting an active end portion (2) coated with a diamond film obtained by the CVD growth technique, having superficial accidents (10) that are arranged and dimensioned to produce a substantial increase of the seating area for the diamond film and an increased degree of mechanical interference with the latter. This invention refers to the cutting tool above and to the process of obtaining said tool, to be generally used for cutting, drilling, abrading and trimming, and particularly to be coupled to ultrasonic systems.Type: GrantFiled: June 7, 2002Date of Patent: April 20, 2010Assignee: Fundacao De Amparo A Pesquisa Do Estado De Sao PauloInventors: Vladimir Jesus Trava Airoldi, Evaldo Jose Corat, Joao Roberto Moro
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Patent number: 7648831Abstract: The purpose of the present invention is to provide a process for protection of enzymatic biocatalysts, constituted by a primary support, wrapped by a secondary matrix. More particularly, the invention is embodied as a bioreactor with a configuration that preserves the physical integrity and catalytic activity of the biocatalyst after long runs, and at the same time allows an easy separation of the protected biocatalyst from the solid, precipitated during the reaction course. Still more particularly, the invention refers to the use of the bioreactor herein described for the enzymatic synthesis of ?-lactam antibiotics, including the insoluble enzymatic catalysts, which have a primary matrix for immobilization involved by a secondary matrix, which is able to preserve 100% of the catalyst physical integrity and approximately 100% of its catalytic activity.Type: GrantFiled: November 24, 2003Date of Patent: January 19, 2010Assignees: Fundacao Universidade Federal de Sao Carlos, Fundacao de Amparo a Pesquisa do Estado de Sao PauloInventors: Roberto de Campos Giordano, Raquel de Lima Camargo Giordano, Andrea Lopes de Oliveira Ferreira
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Patent number: 7572433Abstract: The invention concerns a process for the extraction of acid or basic oxides contained in a vegetal matter, more specifically it concerns the extraction of silica from rice husks. The invention also concerns pure oxides extracted from vegetal matter. The invention also concerns the process for the extraction of carbon-rich oxide compositions from vegetal matter, and compositions obtained through said process.Type: GrantFiled: February 19, 2001Date of Patent: August 11, 2009Assignee: Fundacao de Amparo A Pesquisa Do Estado de Sao PauloInventors: Milton F. De Souza, Paulo Dos Santos Batista, Jefferson B. L. Liborio
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Publication number: 20090017158Abstract: A process for obtaining an increase in the concentration and/or production of milk protein and/or improving reproductive performance. The process includes administering to a mammal a composition including at least one unsaturated fatty acid, or a derivative thereof, and at least one feed supplement, wherein the combination is administered in an amount such that the mammal absorbs 1 g to 95 g of the at least one unsaturated fatty acid, or the derivative thereof, per day.Type: ApplicationFiled: July 18, 2008Publication date: January 15, 2009Applicant: Fundacao De Amparo A Pesquisa Do Estado De Sao PauloInventors: Dante Pazzanese Duarte Lanna, Mark A. McGuire, Sergio Raposo de Medeiros, Dimas Estrasulas de Oliveira, Luis Januario Aroeira
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Publication number: 20080267944Abstract: This invention refers to the process for obtaining the recombinant prothrombin activating protease (rLopap) in monomeric form, the recombinant prothrombin activating protease (rLopap), as well as its amino acid sequence. In addition to that, this invention also refers to the use of this protease for depleting the blood fibrinogen, and serve as diagnosis kit for dysprothrombinemias. This invention describes the obtainence in recombinant form and the characterization of a prothrombin activator protease of 21 kDa, named rLopap (Lonomia obliqua prothrombin activator protease), with serineproteases characteristics however it shows sequence of conserved amino acids as in a lipocalin family. The protein presents pro-coagulating activity, depleting blood fibrinogen and prolonging the coagulation time of human blood/plasma. The obtainence of rLopap in its recombinant form and showing adequate activity for allowing clinical Pharmacology essays is presented in this invention.Type: ApplicationFiled: August 24, 2005Publication date: October 30, 2008Applicants: Biolab Sanus Famaceutica Ltda., Fundacao De Amparo A Pesquisa Do Estado De Sao Paulo - FapespInventors: Ana Marisa Chudzinski-Tavassi, Cleyson Valenca Reis, Paulo Lee Ho, Celso Romero Ramos