Abstract: A process to obtain dibenzylbutyrolactonic lignans from (-)-cubebin, isolated from a Piperaceae, especially Piper cubeba, and from (-)-methylpluviatolide, isolated from a Rutacea, especially Zanthoxylum naranjillo; their synthetic and semi-synthetic derivatives and tetrahydrofuranic lignans, such as galgravin and veragensin, isolated from Nectandra megapotamica, as well as the analgesic and anti-inflammatory activities of said lignans, and the topical and/or systemic formulations. Also presented is a therapeutic method using topic and/or systemic formulations based on said lignans for the treatment of inflammation and/or pain.
Type:
Application
Filed:
April 28, 2006
Publication date:
September 4, 2008
Applicant:
FUNDACADO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO
Inventors:
Marcio Luis Andrade e Silva, Jairo Kenupp Bastos, Paulo Marcos Donate, Sergio de Albuquerque, Rosangela da Silva