Abstract: The present invention refers to new epitopes recognized by CD4+ T-lymphocytes. In addition, the present invention refers to the uses of such epitopes and their combinations, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to a composition comprising said epitopes and the uses of said composition, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to anti-HIV-1 prophylactic vaccines and therapeutic vaccines. Furthermore, the present invention refers to a method for the identification of epitopes and methods for treating or preventing an infection caused by the HIV-1 virus.
Type:
Application
Filed:
March 5, 2008
Publication date:
October 23, 2008
Applicants:
FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO, FUNDACAO ZERBINI, UNIVERSIDADE DE SAO PAULO - USP
Inventors:
Edecio Cunha Neto, Jorge Elias Kalil Filho, Simone Goncalves Da Fonseca
Abstract: This patent of invention reports the method for the preparation of 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties: the sample denominated 37 compound was obtained with high yield and purity with ultrasonic technique presenting cytostatic activity (growth inhibition) in the concentrations evaluated and cytotoxic activity (cellular death) from the concentration of 0.25 mg/mL against nine different types of human cancer cell lines. This compound has a LD50, equals to 8.54 g/Kg. That means this product can be considered itself as practically nontoxic. Doxorubicin, anticarcinogen medicine used as reference in all these tests, is a product extremely toxic (LD50 of 20 mg/Kg) and it does not inhibit the growth of Mama NCI-ADR cell line (the one that expresses the phenotype of resistance against multiple drugs), therefore, out product presented a strong cytostatic activity.
Type:
Grant
Filed:
November 28, 2003
Date of Patent:
October 7, 2008
Assignee:
Fundação de Amparo a Pesquisa Do Estado de São Paulo
Inventors:
José Agustin Quincoces Suárez, Klaus Peseke, Markus Kordian, João Ernesto Carvalho, Luciana Konecny Kohn, Márcia Aparecida Antônio, Heloiza Brunhari
Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6?-dinitrohinokinin and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
Type:
Application
Filed:
December 6, 2007
Publication date:
April 17, 2008
Applicant:
Fundacao De Amparo A Pesquisa Do Estado de Sao Paulo
Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6?-dinitrohinokinine and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
Type:
Grant
Filed:
March 25, 2003
Date of Patent:
January 8, 2008
Assignee:
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Abstract: Modern sugarcane cultivars are complex hybrids resulting from crosses among several species of the Saccharum genus. Traditional breeding methods have been extensively employed in different countries along the past decades to develop varieties with increased sucrose yield, and resistant to plagues and diseases. Conventional varietal improvement is, however, limited by the narrow pool of suitable markers. In this sense, molecular genetics is seen as a promising tool to assist in the process of molecular marker identification. The present invention concerns the identification of 348 genes associated with sucrose content in sugarcane plants. The genes were found to be differentially expressed when high sucrose and low sucrose plants and populations of plants were compared and/or when high and low sucrose internodes were compared. The expression data was obtained using cDNA microarray and quantitative PCR technologies.
Type:
Application
Filed:
March 8, 2007
Publication date:
December 20, 2007
Applicants:
UNIVERSIDADE DE SAO PAULO -- USP., UNIVERSIDADE FEDERAL DE SAO PAULO -- UNIFESP., UNIVERSIDADE ESTADUAL DE CAMPINAS -- UNICAMP., FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO -- FAPESP., CENTRO DE TECNOLOGIA CANAVIEIRA, CENTRAL DE ALCOOL LUCELIA LTDA.
Inventors:
Glaucia Souza, Flavia Papini-Terzi, Flavia Rocha, Alessandro Waclawovsky, Ricardo Vencio, Joselia Marques, Juliana de Maria Felix, Marcelo Teixeira, Marcos Buckeridge, Amanda Pereira de Souza, Eugenio Ulian
Abstract: This invention relates to the isolation and characterization of an operon from the organism Xylella fastidiosa. This operon, referred to as the XfGUM operon, contains 9 genes, and is involved in the production of a compound with xanthan gum like properties. The expression products of the operon and genes are also a part of the invention, as are various uses of these.
Type:
Grant
Filed:
May 9, 2000
Date of Patent:
October 23, 2007
Assignee:
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Inventors:
Paulo Arruda, Felipe Rodrigues da Silva, Edson Luis Kemper, Andre Vettorc, Adilson Leite, Marcio Jose da Silva
Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
Type:
Grant
Filed:
July 12, 2004
Date of Patent:
May 30, 2006
Assignee:
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Inventors:
Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini
Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
Type:
Grant
Filed:
July 12, 2004
Date of Patent:
April 25, 2006
Assignee:
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Inventors:
Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini
Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
Type:
Grant
Filed:
July 12, 2004
Date of Patent:
March 28, 2006
Assignee:
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Inventors:
Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini
Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
Type:
Grant
Filed:
February 28, 2003
Date of Patent:
February 8, 2005
Assignee:
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Inventors:
Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini