Patents Assigned to Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
  • Publication number: 20080260766
    Abstract: The present invention refers to new epitopes recognized by CD4+ T-lymphocytes. In addition, the present invention refers to the uses of such epitopes and their combinations, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to a composition comprising said epitopes and the uses of said composition, particularly in the treatment or prevention of disorders caused by the HIV-1 virus. The present invention also refers to anti-HIV-1 prophylactic vaccines and therapeutic vaccines. Furthermore, the present invention refers to a method for the identification of epitopes and methods for treating or preventing an infection caused by the HIV-1 virus.
    Type: Application
    Filed: March 5, 2008
    Publication date: October 23, 2008
    Applicants: FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO, FUNDACAO ZERBINI, UNIVERSIDADE DE SAO PAULO - USP
    Inventors: Edecio Cunha Neto, Jorge Elias Kalil Filho, Simone Goncalves Da Fonseca
  • Patent number: 7432401
    Abstract: This patent of invention reports the method for the preparation of 1,5-bis(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one and derivatives with antitumoral properties: the sample denominated 37 compound was obtained with high yield and purity with ultrasonic technique presenting cytostatic activity (growth inhibition) in the concentrations evaluated and cytotoxic activity (cellular death) from the concentration of 0.25 mg/mL against nine different types of human cancer cell lines. This compound has a LD50, equals to 8.54 g/Kg. That means this product can be considered itself as practically nontoxic. Doxorubicin, anticarcinogen medicine used as reference in all these tests, is a product extremely toxic (LD50 of 20 mg/Kg) and it does not inhibit the growth of Mama NCI-ADR cell line (the one that expresses the phenotype of resistance against multiple drugs), therefore, out product presented a strong cytostatic activity.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: October 7, 2008
    Assignee: Fundação de Amparo a Pesquisa Do Estado de São Paulo
    Inventors: José Agustin Quincoces Suárez, Klaus Peseke, Markus Kordian, João Ernesto Carvalho, Luciana Konecny Kohn, Márcia Aparecida Antônio, Heloiza Brunhari
  • Publication number: 20080090901
    Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6?-dinitrohinokinin and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
    Type: Application
    Filed: December 6, 2007
    Publication date: April 17, 2008
    Applicant: Fundacao De Amparo A Pesquisa Do Estado de Sao Paulo
    Inventors: Marcio Luis Andrade SILVA, Sergio ALBUQUERQUE, Gustavo Henrique Bianco SOUZA, Jairo Kenupp BASTOS, Rosangela SILVA
  • Patent number: 7317114
    Abstract: The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves of Zanthoxylum naranjillo or Piper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6?-dinitrohinokinine and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: January 8, 2008
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Márcio Luis Andrade Silva, Sérgio Albuquerque, Gustavo Henrique Bianco Souza, Jairo Kenupp Bastos, Rosângela Silva
  • Publication number: 20070292874
    Abstract: Modern sugarcane cultivars are complex hybrids resulting from crosses among several species of the Saccharum genus. Traditional breeding methods have been extensively employed in different countries along the past decades to develop varieties with increased sucrose yield, and resistant to plagues and diseases. Conventional varietal improvement is, however, limited by the narrow pool of suitable markers. In this sense, molecular genetics is seen as a promising tool to assist in the process of molecular marker identification. The present invention concerns the identification of 348 genes associated with sucrose content in sugarcane plants. The genes were found to be differentially expressed when high sucrose and low sucrose plants and populations of plants were compared and/or when high and low sucrose internodes were compared. The expression data was obtained using cDNA microarray and quantitative PCR technologies.
    Type: Application
    Filed: March 8, 2007
    Publication date: December 20, 2007
    Applicants: UNIVERSIDADE DE SAO PAULO -- USP., UNIVERSIDADE FEDERAL DE SAO PAULO -- UNIFESP., UNIVERSIDADE ESTADUAL DE CAMPINAS -- UNICAMP., FUNDACAO DE AMPARO A PESQUISA DO ESTADO DE SAO PAULO -- FAPESP., CENTRO DE TECNOLOGIA CANAVIEIRA, CENTRAL DE ALCOOL LUCELIA LTDA.
    Inventors: Glaucia Souza, Flavia Papini-Terzi, Flavia Rocha, Alessandro Waclawovsky, Ricardo Vencio, Joselia Marques, Juliana de Maria Felix, Marcelo Teixeira, Marcos Buckeridge, Amanda Pereira de Souza, Eugenio Ulian
  • Patent number: 7285409
    Abstract: This invention relates to the isolation and characterization of an operon from the organism Xylella fastidiosa. This operon, referred to as the XfGUM operon, contains 9 genes, and is involved in the production of a compound with xanthan gum like properties. The expression products of the operon and genes are also a part of the invention, as are various uses of these.
    Type: Grant
    Filed: May 9, 2000
    Date of Patent: October 23, 2007
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Paulo Arruda, Felipe Rodrigues da Silva, Edson Luis Kemper, Andre Vettorc, Adilson Leite, Marcio Jose da Silva
  • Patent number: 7052698
    Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: May 30, 2006
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini
  • Patent number: 7033592
    Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: April 25, 2006
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini
  • Patent number: 7018634
    Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: March 28, 2006
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini
  • Patent number: 6852322
    Abstract: The invention relates to Leptospiral surface proteins, and the nucleic acid molecules which encode them. Various uses are described, including immunoprophylactic, diagnostic and therapeutic methods.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: February 8, 2005
    Assignee: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
    Inventors: Ana L. T. O. Nascimento, Paulo L. Ho, Elizabeth A. L. Martins, Luciana C. C. Leite, Marcia Gamberini