Patents Assigned to FUNDACIÓ INSTITUCIÓ CATALÀ DE RECERCA I ESTUDIS AVANÇATS
  • SECRETED SPLICING VARIANT OF MAMMAL KLOTHO AS A MEDICAMENT FOR COGNITION AND BEHAVIOUR IMPAIRMENTS
    Publication number: 20190030138
    Abstract: The invention discloses using secreted splicing variant of mammal Klotho (s-KL) as an agent for the prevention N and/or treatment of cognitive and/or behaviour impairments. It also refers to gene constructs and expression vectors useful in gene therapy for the delivery of said s-KL variant to the central nervous system of a mammal, in particular a rodent or a human. Pharmaceutical compositions comprising either the protein s-KL or any gene construct for expressing the protein in the CNS are also disclosed.
    Type: Application
    Filed: November 21, 2016
    Publication date: January 31, 2019
    Applicants: UNIVERSITAT AUTONOMA DE BARCELONA, FUNDACIÓ INSTITUCIÓ CATALÀ DE RECERCA I ESTUDIS AVANÇATS
    Inventors: Miguel Chillon Rodriguez, Anna Masso Chacon, Assumpció Bosch Merino