Abstract: The present invention provides a process for preparing a self-standing catecholamine-based membrane, the process comprising the steps of: (a) cross-linking a catechol derivative with an amine selected from the group consisting of: a known aliphatic amine hydrocarbon of formula (II); and an aromatic amine of formula (IIbis), in a liquid medium, wherein both the catechol and the amine are soluble, at a pH comprised from 6.5 to 10, and under appropriate agitation to create a catecholamine membrane in the air/liquid interface in the absence of any support; and b) isolating the membrane resulting from step (a) from the air/liquid interface. The resulting self-standing catecholamine-based membrane was robust, easy to handle and manipulate, highly flexible and adaptable to any kind of surface without breaking, and adhesive.

Abstract: The present invention provides a liposome encapsulating an autoantigen, wherein the liposome has a size comprised from 500 to 15000 nm and the liposome membrane comprises phosphatydilserine (PS) in an amount comprised from 10 to 40% by weight with respect to the total membrane liposomal composition. Pharmaceutical or veterinary compositions comprising a therapeutically effective amount of said liposome are also provided. Further, the invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use as a medicament, particularly for the treatment of autoimmune diseases. Finally the present invention provides liposomes and pharmaceutical or veterinary compositions as defined above for use in the restoration of tolerance to self in a patient suffering from an autoimmune disease.

Abstract: An apparatus and a method using no switching elements for multiplexing and reading arrays of sensors whose electrical resistance is modulated by the signals to be measured are proposed. Sensor elements are arranged in groups and columns where each column is fed with a continuous voltage waveform of different amplitude, frequency and phase characteristics which then produce current signals that are modulated by the variable resistance signals to be measured. Modulated currents are summed row-wise and collected at the read-out circuits, either by applying a constant voltage to each row of the array or by connecting a capacitor and converting these current summations into output voltage signals. The read-out circuits de-multiplex each individual sensor signal to be measured by lock-in demodulation according to the frequencies and phases employed for the stimulation of each column.

Abstract: An amorphous boron nitride compound may include a boron nitride compound, where the boron nitride compound may be amorphous and may be doped with carbon or hydrogen. In the boron nitride compound, a total content of the carbon or the hydrogen may be in a range of about 0.1 at % to about 35 at % of a total atomic content.

Abstract: A graphene transistor system for measuring electrophysiological signals uses flexible epicortical and intracortical arrays of graphene solution-gated field-effect transistors (gSGFETs) to record infraslow signals alongside signals in the typical local field potential bandwidth. The graphene transistor system includes a processing unit, and at least one graphene transistor (gSGFET) a tunable voltage source connected to the drain and source terminals of the transistor (gSGFET), and at least one filter configured to acquire and split the signal from the transistor into at least a low frequency band signal and high frequency band signal, which are amplifiable with a gain value.

Abstract: An apparatus and a method using no switching elements for multiplexing and reading arrays of sensors whose electrical resistance is modulated by the signals to be measured are proposed. Sensor elements are arranged in groups and columns where each column is fed with a continuous voltage waveform of different amplitude, frequency and phase characteristics which then produce current signals that are modulated by the variable resistance signals to be measured. Modulated currents are summed row-wise and collected at the read-out circuits, either by applying a constant voltage to each row of the array or by connecting a capacitor and converting these current summations into output voltage signals. The read-out circuits de-multiplex each individual sensor signal to be measured by lock-in demodulation according to the frequencies and phases employed for the stimulation of each column.

Abstract: A process for the preparation of a dry crystalline metal organic framework which comprises: a) spray drying at least one metal ion and at least one organic ligand which is at least bidentate into a spray dryer in the presence of a solvent, wherein the reaction of the at least one metal ion with the at least one organic ligand to yield the metal organic framework and the drying of the obtained metal organic framework take place simultaneously inside the spray dryer, and b) collecting the formed dry crystalline metal organic framework.