Abstract: The present invention relates to a novel method for an accurate quantification in intestinal samples of Faecalibacterium prausnitzii phylogroup I members (PHGI) and/or Faecalibacterium prausnitzii phylogroup II members (PHGII). It further relates to a method for detecting intestinal diseases, including the screening, diagnosis, differential diagnosis, and/or monitoring of disease activity or progression in a human subject comprising determining the abundance of PHGI and/or PHGII in an intestinal sample from said subject. Moreover, it relates to a method for the prediction of the efficacy of a drug in the therapeutic treatment of an intestinal disease in a human subject comprising determining the abundance of PHGI and/or PHGII in an intestinal sample from said subject.
Type:
Grant
Filed:
August 11, 2016
Date of Patent:
April 12, 2022
Assignees:
Universitat de Girona, Fundacio Institut D'Investigacio Biomedica de Girona Dr. Josep Trueta, Goodgut S.L.
Abstract: The present invention concerns methods, in particular in vitro methods, for diagnosing liver fibrosis in a subject suffering from obesity, or for selecting a subject suffering from obesity for liver biopsy or for treatment. The present invention also pertains to methods for screening a probiotic, a prebiotic, a chemical compound or a biological compound suitable for preventing and/or treating liver fibrosis.
Type:
Grant
Filed:
April 23, 2015
Date of Patent:
July 2, 2019
Assignees:
VAIOMER, UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA, FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE GIRONA DR. JOSEP TRUETA
Inventors:
Michael Courtney, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez-Real, Sandrine Païssé