Abstract: The present invention relates to pharmaceutical compositions comprising a compound selected from the group consisting of: a) a polypeptide of SEQ ID NO:1, b) a functionally equivalent variant of the polypeptide according to a), c) a polynucleotide encoding a) or b), d) a vector comprising a polynucleotide according to c), e) a cell capable of secreting into the medium a polypeptide according to a) or b), and f) a nanoparticle comprising the polypeptide according to a) or b) and a pharmaceutically acceptable excipient. The invention also relates to the use of said compounds or pharmaceutical compositions for treatment and/or prevention of ischemia injury or ischemia/reperfusion injury in a subject.
Type:
Grant
Filed:
March 14, 2017
Date of Patent:
July 6, 2021
Assignee:
FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU
Abstract: The present invention is directed to in vitro methods for determining the fitness of a subject based on the determination of the expression levels of different genes. The invention also provides an in vitro method for selecting a subject as having a fitness level suitable to participate in an endurance sport, for monitoring the response to training of a subject during an endurance exercise training and for selecting a personalized training program aimed at improving fitness of a subject, based on the determination of the expression levels of said genes, as well as a kit comprising reagents for determining said expression levels and the use thereof, a computer program and a computer-implemented method.
Type:
Application
Filed:
November 26, 2018
Publication date:
May 6, 2021
Applicants:
UNIVERSITAT POLITECNICA DE CATALUNYA, FUNDACIO INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU, SUMMIT 2014, S.L.
Inventors:
Alexandre PERERA LLUNA, Maria MAQUEDA GONZALEZ, Emma ROCA RODRIGUEZ, Jose Manuel SORIA FERNANDEZ
Abstract: Disclosed herein are methods and devices used to recognize the extent and deepness of infarcted tissue, such as chronic myocardial infarcted tissue. This applies to the heart tissue, but can also be used to assess cicatricial processes in other organs. Examples include injecting pulses of alternating current at a broadband of frequencies while measuring the voltage signal continuously (at a very high sampling rate) to obtain the electrical impedance (Z(f,t)) during the entire cardiac cycle. The impedance measurements may be taken using an intracavitary electrocatheter.
Type:
Application
Filed:
March 30, 2016
Publication date:
April 18, 2019
Applicants:
UNIVERSITAT POLITÉCNICA DE CATALUNYA, FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU
Abstract: The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle; L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms; wherein the meanings of X, n, p, Y and s are further specified in the description; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer.
Type:
Application
Filed:
December 15, 2009
Publication date:
October 27, 2011
Applicants:
FUNDACIÓ PRIVADA INSTITUT CATALÁ DE NANOTECNOLOGIA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, FUNDACIÓ INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU, UNIVERSITAT DE VALÉNCIA, UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
Inventors:
Victor Franco Puntes, Fernando Domìnguez Puente, Francisco Manuel Romero Martínez, Óscar Gallego Rubio