Patents Assigned to Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz
  • Methods of treating or preventing pyruvate kinase deficiency
    Patent number: 12163151
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
    Type: Grant
    Filed: February 22, 2022
    Date of Patent: December 10, 2024
    Assignees: Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A, M.P., Consorcio Centro de Investigación Biomédica en Red, M. P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Diaz
    Inventors: Jose C. Segovia, Maria G. Gomez, Susana Navarro, Nestor Meza, Juan Bueren, Maria G. Bravo
  • LENTIVIRAL VECTORS FOR DELIVERY OF PKLR TO TREAT PYRUVATE KINASE DEFICIENCY
    Publication number: 20230355807
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
    Type: Application
    Filed: March 8, 2023
    Publication date: November 9, 2023
    Applicants: Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Consorcio Centro de Investigación Biomédica en Red, M.P.
    Inventors: Jose Carlos SEGOVIA, Maria G. GOMEZ, Susana NAVARRO, Nestor MEZA, Juan Antonio BUEREN, Maria G. BRAVO
  • Lentiviral vectors for delivery of to treat pyruvate kinase deficiency
    Patent number: 11642422
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: May 9, 2023
    Assignees: Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Consorcio Centro de Investigación Biomédica en Red, M.P.
    Inventors: Jose Carlos Segovia, Maria G. Gomez, Susana Navarro, Nestor Meza, Juan Antonio Bueren, Maria G. Bravo
  • Methods of treating or preventing pyruvate kinase deficiency
    Patent number: 11286501
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: March 29, 2022
    Assignees: CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS O.A, M.P., CONSORCIO CENTRO DE INVESTIGACION BIOMFDICA EN RED, M.P., FUNDACION INSTITUTO DE INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ
    Inventors: Jose C. Segovia, Maria G. Gomez, Susana Navarro, Nestor Meza, Juan Bueren, Maria G. Bravo
  • LENTIVIRAL VECTORS FOR DELIVERY OF PKLR TO TREAT PYRUVATE KINASE DEFICIENCY
    Publication number: 20210187126
    Abstract: The present disclosure provides polynucleotide cassettes, expression vectors and methods for the expression of a gene in mammalian cells to provide gene therapy for pyruvate kinase deficiency.
    Type: Application
    Filed: October 16, 2018
    Publication date: June 24, 2021
    Applicants: Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A, M.P., Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Consorcio Centro de Investigación Biomédica en Red, M.P.
    Inventors: Jose Carlos SEGOVIA, Maria G. GOMEZ, Susana NAVARRO, Nestor MEZA, Juan Antonio BUEREN, Maria G. BRAVO
  • SOCS1-DERIVED PEPTIDE FOR USE IN CHRONIC COMPLICATIONS OF DIABETES
    Publication number: 20200138903
    Abstract: The present invention relates to a SOCS1-derived peptide for use in chronic complications of diabetes, particularly ocular, renal, nerve and vascular complications, as well as compositions containing same and isolated polynucleotides encoding same. The present invention also relates to the SOCS1-derived peptide for topical use in the treatment and/or prevention of neurodegenerative diseases of the retina, particularly in the early stages of diabetic retinopathy and other diseases of the retina in which neurodegeneration plays an essential role.
    Type: Application
    Filed: November 20, 2019
    Publication date: May 7, 2020
    Applicants: Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca, Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma De Madrid
    Inventors: Jesús Egido De Los Ríos, Carmen Gómez Guerrero, Rafael Simó Canonge, Cristina Hernández Pascual
  • SOCS1-derived peptide for use in chronic complications of diabetes
    Patent number: 10532082
    Abstract: The present invention relates to a SOCS1-derived peptide for use in chronic complications of diabetes, particularly ocular, renal, nerve and vascular complications, as well as compositions containing same and isolated polynucleotides encoding same. The present invention also relates to the SOCS1-derived peptide for topical use in the treatment and/or prevention of neurodegenerative diseases of the retina, particularly in the early stages of diabetic retinopathy and other diseases of the retina in which neurodegeneration plays an essential role.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: January 14, 2020
    Assignees: Fundació Hospital Universitari Vall d'Hebron-Institut de Recerca, Fundación Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma De Madrid
    Inventors: Jesús Egido De Los Rios, Carmen Gómez Guerrero, Rafael Simó Canonge, Cristina Hernández Pascual