Patents Assigned to FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL GREGORIO MARAÑÓN
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Patent number: 11672463Abstract: The device for locating cardiac arrhythmias comprises a three-dimensional reconstruction of the patient's torso and a number of surface electrodes, wherein the three-dimensional reconstruction of the patient's torso is generated through a number of images obtained by means of at least one camera. In particular, the device comprises elements for locating the surface electrodes, which detect the position of the electrodes with respect to the patient's torso, and data processing elements that generate, on the basis of the three-dimensional reconstruction and the position of the electrodes, a surface electrocardiographic map, and said surface electrocardiographic map has a number of data corresponding to readings of the surface electrodes related to areas of the three-dimensional reconstruction.Type: GrantFiled: October 29, 2015Date of Patent: June 13, 2023Assignees: FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON, UNIVERSITAT POLITECNICA DE VALENCIAInventors: Andreu Martinez Climent, Felipe Atienza Fernandez, Angel Arenal, Francisco Fernandez Aviles, Maria S. Guillem Sanchez
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Patent number: 11185522Abstract: The present invention relates to the treatment of sepsis and sepsis-associated acute kidney injury (SA-AKI). More specifically, it relates to cilastatin for use in a method of treating sepsis and/or SA-AKI and reducing its associated mortality, in a mammalian subject. It is further directed to methods for treating sepsis and/or SA-AKI; and to pharmaceutical compositions for use in the methods of the invention.Type: GrantFiled: June 23, 2017Date of Patent: November 30, 2021Assignee: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL GREGORIO MARAÑÓNInventors: Alberto Tejedor Jorge, Alberto Lazaro Fernandez, Blanca Humanes Sanchez, Maria Angeles Gonzalez-Nicolas Gonzalez
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Publication number: 20210040450Abstract: The present invention provides an in vitro method for obtaining and purifying regulatory T cells from thymic tissue (or thyTreg cells), which makes it possible to obtain more than 10 billion cells from a single thymus. These thyTregs obtained in the invention have a purity of more than 95% and very high suppressive capacity, survival and viability, in addition to being safe from a clinical viewpoint. The foregoing would not require the use of massive ex vivo cell expansion protocols. The transfer of these thyTreg cells to patients enables immune tolerance induction. Thus, said cells may be used as cell therapy to induce immune tolerance in the treatment and/or prevention of transplant rejections and in autoimmune diseases.Type: ApplicationFiled: March 1, 2019Publication date: February 11, 2021Applicant: Fundaciön Para la Investigaciön Biomédica del Hospital Gregorio MarañónInventors: Rafael CORREA ROCHA, Marjorie PION, Esther BERNALDO DE QUIRÓS PLAZA
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Publication number: 20200371107Abstract: A method and system for detecting, manipulating and isolating circulating tumor cells found in organic fluids comprising a simplified laser assisted transfer process. A liquid specimen of the organic fluid containing an enriched population of tumor cells and a population of non-tumor cells is spread onto a donor substrate with an interlayer comprising a semi-transparent polymeric adhesive tape. A fluorescent staining of at least one of the cell populations present in the liquid specimen is required to identify-using optical and fluorescence microscopy, the location of the cells to be manipulated and/or isolated. The laser beam energy is absorbed by the polymeric adhesive tape giving place to the formation of a blister that mechanically interacts with the liquid specimen and such interaction can induce the expulsion of a portion of the liquid specimen comprising the selected tumor cells or non-tumor cells, which can be a single cell or a cell cluster, towards the receiving substrate.Type: ApplicationFiled: January 29, 2018Publication date: November 26, 2020Applicant: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL GREGORIO MARAÑÓNInventors: Carlos Luis MOLPECERES ÁLVAREZ, Sara LAUZURICA SANTIAGO, Andrés MÁRQUEZ FERNÁNDEZ, David MUÑOZ MARTÍN, Miguel MORALES FURIÓ, Mónica COLINA BRITO, MARTÍN JIMÉNEZ, Miguel, Rocío RAMOS MEDINA, Andrés MUÑOZ MARTÍN, Javier GAYARRE NAVARRO, Tatiana MASSARRAH SÁNCHEZ, María DEL MONTE MILLÁN
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Publication number: 20180310924Abstract: Mouth protector device with tongue depressor, comprising a first cover (1) for protecting the lip and the teeth of the upper jaw and a second cover (2) for protecting the lip and the teeth of the lower jaw, both covers being connected and articulated in relation to each other by an opening and locking regulator (3), which holds the patient's mouth open for the introduction of exploration or operating instruments through the oral cavity, wherein the second cover (2) has a through groove (4) for the insertion of a semi-rigid tongue depressor (5) which depresses and holds back the tongue. The first (1) and second (2) covers further comprise side extensions (6) for protecting the row of premolars and molars and at least one tape (7) for connecting the rear ends thereof, said tape passing around the rear part of the patient's head, in order to provide the device with increased stability.Type: ApplicationFiled: October 19, 2016Publication date: November 1, 2018Applicant: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL GREGORIO MARAÑÓNInventors: Guillermo Juan Rodríguez Bernal, Javier Casanova Barea
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Patent number: 9757349Abstract: Use of cilastatin to reduce the nephrotoxicity of different compounds. The invention refers to use of cilastatin to prepare a medicinal product to reduce the nephrotoxicity of a nephrotoxic compound that enters the cells of the proximal tubule through cholesterol rafts. The invention is based on the discovery that a great number of nephrotoxic compounds, including drugs, enter the cells of the proximal tubule through the cholesterol rafts, and that cilastatin is able to interfere with this transport mechanism, decreasing the nephrotoxicity of such compounds to a variable extent. The nephroprotective effect is common to compounds of different chemical nature and solubility and is specific for the kidney, causing no interference with the effects of nephrotoxic drugs having their targets in other organs. Therefore, administration of cilastatin allows for decreasing the nephrotoxic effects of different drugs without reducing their therapeutic effects.Type: GrantFiled: August 10, 2016Date of Patent: September 12, 2017Assignee: FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANONInventors: Alberto Tejedor Jorge, Alberto Lazaro Fernandez, Sonia Camano Paez, Ana Maria Torres Redondo, Jose Antonio Lazaro Manero, Manuela Castilla Barba, Maria del Carmen De Lucas Collantes
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Patent number: 9522128Abstract: Use of cilastatin to reduce the nephrotoxicity of different compounds. The invention refers to use of cilastatin to prepare a medicinal product to reduce the nephrotoxicity of a nephrotoxic compound that enters the cells of the proximal tubule through cholesterol rafts. The invention is based on the discovery that a great number of nephrotoxic compounds, including drugs, enter the cells of the proximal tubule through the cholesterol rafts, and that cilastatin is able to interfere with this transport mechanism, decreasing the nephrotoxicity of such compounds to a variable extent. The nephroprotective effect is common to compounds of different chemical nature and solubility and is specific for the kidney, causing no interference with the effects of nephrotoxic drugs having their targets in other organs. Therefore, administration of cilastatin allows for decreasing the nephrotoxic effects of different drugs without reducing their therapeutic effects.Type: GrantFiled: November 13, 2015Date of Patent: December 20, 2016Assignee: Fundacion Para La Investigacion Biomedica Del Hospital Gregorio MaranonInventors: Alberto Tejedor Jorge, Alberto Lazaro Fernandez, Sonia Camano Paez, Ana Maria Torres Redondo, Jose Antonio Lazaro Manero, Manuela Castilla Barba, Maria del Carmen De Lucas Collantes
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Patent number: 9216185Abstract: Use of cilastatin to reduce the nephrotoxicity of different compounds. The invention refers to use of cilastatin to prepare a medicinal product to reduce the nephrotoxicity of a nephrotoxic compound that enters the cells of the proximal tubule through cholesterol rafts. The invention is based on the discovery that a great number of nephrotoxic compounds, including drugs, enter the cells of the proximal tubule through the cholesterol rafts, and that cilastatin is able to interfere with this transport mechanism, decreasing the nephrotoxicity of such compounds to a variable extent. The nephroprotective effect is common to compounds of different chemical nature and solubility and is specific for the kidney, causing no interference with the effects of nephrotoxic drugs having their targets in other organs. Therefore, administration of cilastatin allows for decreasing the nephrotoxic effects of different drugs without reducing their therapeutic effects.Type: GrantFiled: July 11, 2008Date of Patent: December 22, 2015Assignee: Fundacion Para La Investigacion Biomedica Del Hospital Gregorio MaranonInventors: Alberto Tejedor Jorge, Alberto Lazaro Fernandez, Sonia Camaño Paez, Ana Maria Torres Redondo, José Antonio Lazaro Manero, Manuela Castilla Barba, María del Carmen De Lucas Collantes
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Publication number: 20130069945Abstract: This invention describes a method, the starting point of which is a three-dimensional image of the heart. A region of interest is defined on said image. Moreover, the surface which will be represented in the display in the form of a three-dimensional polygon mesh is defined. Each vertex of the mesh is associated with a function which assigns weights to each element in the region of interest. Display parameters are assigned to the vertices using said functions together with the intensity values of the elements in the region of interest. Said parameters are used to generate the interactive display of the surface. One application of the method would be the use thereof to help to characterize the myocardial substrate of ventricular tachycardia in patients with ischemic heart disease and to guide ablation procedures for correcting said tachycardia.Type: ApplicationFiled: March 9, 2011Publication date: March 21, 2013Applicants: FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON, UNIVERSIDAD POLITECNICA DE MADRIDInventors: Maria Jesus Ledesma Carbayo, Andrés Santoslleo, Jose Luis Rubioguivernau, Ángel Arenal Maíz, Esther Pérez David, Javier Bermejo Thomas, Francisco Fernández Avilés, Manuel Desco Menendez
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Patent number: 8398859Abstract: Device for haemodiafiltration, which comprises a first circuit for a dialysis solution and a second circuit for blood, so that the toxic substances from the blood flow pass into the dialysis liquid within a haemofilter (11), a liquid pump (20) located upstream of the haemofilter (11) in the first dialysis liquid circuit, is adapted for injecting replacement liquid into the dialysis solution flow after a blood pump (15) finishes pumping blood to the interior of the haemofilter (11).Type: GrantFiled: April 23, 2007Date of Patent: March 19, 2013Assignee: Fundacion Para la Investigacion Biomedica del Hospital Gregorio MaranonInventor: Juan Francisco Del Cañizo López
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Patent number: 8259899Abstract: The invention relates to a multi-modality tomography apparatus (11) including a first tomograph (13) and a second tomograph or imaging system (14) using different tomography techniques, such as X-ray CT tomography and PET or SPECT tomography, or a tomographic or planar optical imaging system, which are located on the same face of a support means (12) which can rotate in both directions of rotation around an axial support shaft (12), such that a subject undergoing examination and placed on a subject support does not have to be moved during a tomographic examination with any of the two tomographs (13, 14) installed on the same face of the support (12).Type: GrantFiled: October 26, 2006Date of Patent: September 4, 2012Assignee: Fundacion Para la Investigacion Biomedica del Hospital Gregorio MaranonInventors: Juan José Vaquero López, Manuel Menéndez Desco
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Patent number: 8246531Abstract: An incubator for imaging with non-ionising radiation adapted for the care of newborn babies, which integrates a system projective or tomographic imaging system, or both simultaneously, which makes use of non-ionising radiation in the band of the electromagnetic spectrum included between ultraviolet light and far infrared, a system which can be used to view a subject (11) located in the incubator (19) such that this projective or tomographic image can be morphological or functional.Type: GrantFiled: December 19, 2007Date of Patent: August 21, 2012Assignee: Fundacion Para la Investigacion Biomedica del Hospital Gregorio MaranonInventors: Juan Jose Vaquero Lopez, Manuel Desco Menendez, Manuel Sanchez Luna
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Publication number: 20090214613Abstract: The invention relates to an endothelized artificial matrix comprising a fibrin gel, which is a superproducer of proantiogenic factors. The inventive matrix comprises a fibrin gel containing embedded endothelial cells which have been transfected in vitro with at least one adenoviral vector containing the sequence encoding at least one proangiogenic factor, which is inserted such that it can be overexpressed in said endothelial cells. The insertion of the aforementioned matrix between a flap and the receptor site thereof during a transplant procedure improves the survival rates of said flap, since the endothelized matrix can induce angiogenesis both in the flap and in the receptor site and, in this way, improve the vascularization of the transplanted area.Type: ApplicationFiled: May 12, 2006Publication date: August 27, 2009Applicant: FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANONInventors: Jose Maria Lasso Vazquez, Paola Nava Perez