Patents Assigned to FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA
  • Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof
    Patent number: 10316302
    Abstract: The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals of the Tenacibaculum sp. strain 20J (CECT7426). Said gene encodes a peptide having at least lactonase activity with a percentage of identity less than 38% with the lactonases described up until now for other species, as well as the sequences of the homologous genes present in other species of the genus Tenacibaculum. Said peptide shows a broad spectrum of activity degrading optionally substituted N-acyl-homoserine lactones (AHLs) of 4-14 carbon atoms in the side chain thereof, is active at pH comprised between 3 and 9, proteinase K- and chymotrypsin-resistant and does not interact with ?-lactam antibiotics.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: June 11, 2019
    Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA
    Inventors: Ana María Otero Casal, Manuel Romero Bernárdez, Celia Mayer Mayer
  • AGENT, PRODUCT AND USE
    Publication number: 20170246258
    Abstract: The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.
    Type: Application
    Filed: April 30, 2015
    Publication date: August 31, 2017
    Applicants: FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA, SERGAS, UNIVERSITY OF SANTIAGO DE COMPOSTELA, FUNDACION RAMÓN DOMINGUEZ, BIOMERIX CORPORATION
    Inventors: Alexandre DE LA FUENTE GONZALEZ, Rafael LOPEZ, Miguel Abal POSADA, Lawrence Patrick LAVELLE, Jr.
  • AGENT, PRODUCT AND USE
    Publication number: 20170049860
    Abstract: The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and/or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.
    Type: Application
    Filed: April 30, 2015
    Publication date: February 23, 2017
    Applicants: Fundacion Pedro Barrie De La Maza,Conde De Fenosa, Sergas, University of Santiago De Compostela, Fundacion Ramon Dominguez, Biomerix Corporation
    Inventors: Alexandre DE LA FUENTE GONZALEZ, Rafael LOPEZ, Miguel Abal POSADA, Lawrence Patrick LAVELLE, JR.
  • METHODS FOR DIAGNOSING FOLLICULAR THYROID CANCER
    Publication number: 20120184452
    Abstract: Methods for diagnosing follicular thyroid cancer, providing a prognosis for follicular thyroid cancer, and monitoring treatment of follicular thyroid cancer, using biomarkers that are differentially expressed in follicular thyroid cancer are provided.
    Type: Application
    Filed: January 6, 2012
    Publication date: July 19, 2012
    Applicants: Universidade de Santiago de Compostela, Fundacion Pedro Barrie de la Maza, Conde De Fenosa, Fundacion Publica Galega de Medicina Xenomica
    Inventors: Maria del Carmen Pastoriza Rodriguez, Maria del Carmen Carneiro Freire, José Manuel Cameselle-Teijeiro, Fernando Dominguez Puente, Anxo Vidal Figueroa