Abstract: The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.
Type:
Grant
Filed:
February 24, 2012
Date of Patent:
March 28, 2017
Assignees:
LABORATORIOS DEL DR. ESTEVE, S.A., FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA
Inventors:
María Eloísa Yuste Herranz, Víctor Sánchez Merino, Carolina Ferreira
Abstract: The invention relates to a method for rapid immunogen selection (RIS) based on the binding a library of recombinant viruses containing randomized HIV gp120 variants of a surface polypeptide displayed to said neutralizing antibodies. The invention relates as well to the use of the HIV gp120 immunogens isolated according to the RIS method of the invention in medicine for the treatment of diseases caused by a virus and in diagnosis for the identification of neutralizing antibodies in a patient.
Type:
Application
Filed:
February 24, 2012
Publication date:
February 6, 2014
Applicants:
FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA -CAIXA, LABORATORIOS DEL DR. ESTEVE, S.A.
Inventors:
María Eloísa Yuste Herranz, Víctor Sánchez Merino, Carolina Ferreira
Abstract: The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.
Type:
Application
Filed:
November 10, 2011
Publication date:
November 14, 2013
Applicants:
LABORATORIOS DEL DR. ESTEVE, S.A., UNIVERSITY OF WASHINGTON, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA - CAIXA
Inventors:
Beatriz Mothe Pujadas, Christian Brander, James I. Mullins