Patents Assigned to Fundacio Clinic per a la Recerca Biomedica
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Publication number: 20240131085Abstract: The present invention provides a solid oral pharmaceutical composition comprising a pharmaceutically effective amount of living microorganisms and one or more pharmaceutically acceptable water absorbing excipient(s), wherein the composition has a water content, determined according to European Pharmacopoeia 9.4, section 2.5.12., from 0.5 to 30% with respect the total weight of the composition. The invention also provides processes for its preparation as well as it use in therapy. The live-cell based composition of the invention is stable at mild conditions.Type: ApplicationFiled: December 15, 2023Publication date: April 25, 2024Applicants: INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS), FUNDACIÓ CLÍNIC PER A LA RECERCA BIOMÈDICA, HOSPITAL CLÍNIC DE BARCELONA, UNIVERSITAT DE BARCELONAInventors: Josep M. SUÑÉ NEGRE, Alex SORIANO VILADOMIU, Andrea AIRA GOMEZ, Csaba FEHER
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Publication number: 20230218846Abstract: A method and a system for determining the amount of oxygen required by a user with respiratory problems are disclosed. First data about several users with respiratory problems is stored in a database. The method a) collects second data from a monitored user while (s)he is performing a test at a first location; b) computes a user’s behavioral model executing a first algorithm on the first and second data; c) collects, every period of time t1, third data of the user while (s)he is performing an activity at a second location; d) adjusts, every period of time t2, the computed user’s behavioral model using the first algorithm, providing a customized user’s behavioral model as a result; and e) computes an estimator of the quantity of oxygen to be delivered to the user by executing a second algorithm on the customized user’s behavioral model.Type: ApplicationFiled: September 13, 2021Publication date: July 13, 2023Applicants: UNIVERSITAT POLITECNICA DE CATALUNYA, FUNDACIÓ CLÍNIC PER A LA RECERCA BIOMÈDICA, HOSPITAL CLÍNIC DE BARCELONA, INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)Inventors: Xavier MASIP BRUIN, Heribert PASCUAL SALDAÑA, Andrés PRIETO GONZÁLEZ, Isabel BLANCO VICH, Albert ALONSO BELTRÁN
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Publication number: 20230053910Abstract: A method involves detecting in a sample an autoantibody binding specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. An autoantibody binds specifically to one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2. A diagnostically useful carrier with a solid phase with an immobilized polypeptide contains one or more from Gluk1, Gluk2, Gluk3, Gluk4 and Gluk5, preferably Gluk2 or a variant thereof. The autoantibody can be used for diagnosing a neurological autoimmune disease or a cancer.Type: ApplicationFiled: August 10, 2022Publication date: February 23, 2023Applicants: Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institució Catalana de Recerca i Estudis Avançats (ICREA), Fundació Clinic per a la Recerca Biomèdica (FCRB)Inventors: Josep Dalmau, Lidia Sabater, Francesc Graus
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Publication number: 20220143107Abstract: The present invention provides a solid oral pharmaceutical composition comprising a pharmaceutically effective amount of living microorganisms and one or more pharmaceutically acceptable water absorbing excipient(s), wherein the composition has a water content, determined according to European Pharmacopoeia 9.4, section 2.5.12., from 0.5 to 30% with respect the total weight of the composition. The invention also provides processes for its preparation as well as it use in therapy. The live-cell based composition of the invention is stable at mild conditions.Type: ApplicationFiled: April 14, 2020Publication date: May 12, 2022Applicants: INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS), FUNDACIÓ CLÍNIC PER A LA RECERCA BIOMÈDICA, HOSPITAL CLÍNIC DE BARCELONA, UNIVERSITAT DE BARCELONAInventors: Josep M. SUÑÉ NEGRE, Alex SORIANO VILADOMIU, Andrea AIRA GOMEZ, Csaba FEHER
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Patent number: 9630962Abstract: The present invention is related to 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, to the preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in the treatment and/or prevention of a non-Hodgkin's lymphoma.Type: GrantFiled: June 16, 2014Date of Patent: April 25, 2017Assignees: HOSPITAL CLINIC DE BARCELONA, FUNDACIÓ CLINIC PER A LA RECERCA BIOMÈDICA, INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER, INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADAInventors: José Ignacio Borrell Bilbao, Jordi Teixido Closa, Raimon Puig De La Bellacasa Cazorla, Dolors Colomer Pujol, Gael Roue, Patricia Pérez-Galán
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Patent number: 9589347Abstract: The method comprising acquiring and analyzing by computer means image information of video sequences of two or more dimensions obtained from contrast-enhanced signals, for example ultrasound, coherence tomography, fluorescence images, or Magnetic Resonance Imaging, of a body part or tissue, for example of an organ, of a living subject; detecting events from said information of video sequences; selecting a Region of Interest of said body part or tissue; computing a first graph representative of a local vascular network of said image information of video sequences in which the edges of the graph are estimated by the temporal relationship among spatially remote signals of said image information of video sequences within a set of video sequences; and using said graph for assessment of vascular networks.Type: GrantFiled: March 20, 2014Date of Patent: March 7, 2017Assignees: EXPERT YMAGING, S.L., HOSPITAL CLINIC I PROVINCIAL DE BARCELONA, FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA (FCRB), UNIVERSITAT DE BARCELONAInventors: Ivan Amat Roldan, Jaime Bosch Genover, Annalisa Berzigotti, Maria Rosa Gilabert Solé
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Patent number: 9445582Abstract: The present invention discloses soluble isoforms of CD5 and CD6, which are scavenger-like lymphocyte receptors, for use in the prophylaxis or therapy of disorders or in therapeutic interventions, which would benefit from an exacerbated immune response to either endogenous or exogenous antigens, resulting from a decrease in lymphocyte subpopulations with regulatory functions and/or increase in lymphocyte subpopulations with effector functions. Special disorders are cell growth disorders, and chronic infections of bacterial, viral, fungal or parasitic origin. The invention also provides animal models for the study and the prophylaxis/treatment of autoimmune diseases, cancer, and chronic infections.Type: GrantFiled: May 29, 2012Date of Patent: September 20, 2016Assignees: FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA, HOSPITAL CLINIC I PROVINCIAL DE BARCELONA, UNIVERSITAT DE BARCELONAInventors: Francisco Lozano Soto, Vanessa Gabriela Martinez, Rafael Fenutria Aumesquet
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Publication number: 20160176866Abstract: The present invention is related to 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, to the preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in the treatment and/or prevention of a non-Hodgkin's lymphoma.Type: ApplicationFiled: June 16, 2014Publication date: June 23, 2016Applicants: INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA, HOSPITAL CLÍNIC DE BARCELONA, FUNDACIÓ CLINIC PER A LA RECERCA BIOMÈDICA (FCRB), INSTITUT D'INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYERInventors: José Ignacio Borrell Bilbao, Jordi Teixido Closa, Raimon Puig De La Bellacasa Cazorla, Dolors Colomer Pujol, Gael Roue, Patricia Pérez-Galán
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Publication number: 20160042514Abstract: The method comprising acquiring and analysing by computer means image information of video sequences of two or more dimensions obtained from contrast-enhanced signals, for example ultrasound, coherence tomography, fluorescence images, or Magnetic Resonance Imaging, of a body part or tissue, for example of an organ, of a living subject; detecting events from said information of video sequences; selecting a Region of Interest of said body part or tissue; computing a first graph representative of a local vascular network of said image information of video sequences in which the edges of the graph are estimated by the temporal relationship among spatially remote signals of said image information of video sequences within a set of video sequences; and using said graph for assessment of vascular networks.Type: ApplicationFiled: March 20, 2014Publication date: February 11, 2016Applicants: EXPERT YMAGING, SL, HOSPITAL CLINIC I PROVINCIAL DE BARCELONA, UNIVERSITAT DE BARCELONA, FUNDACIÓ CLINIC PER A LA RECERCA BIOMÈDICA (FCRB), CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES HEPÁTICAS Y DIGESTIVAInventors: Ivan AMAT ROLDAN, Jaime BOSCH GENOVER, Annalisa BERZIGOTTI, Maria Rosa GILABERT SOLÉ
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Patent number: 9012405Abstract: The present invention concerns a chimeric polypeptide, capable of detecting the antibodies generated in rheumatoid arthritis, comprising at least two citrulinated peptide subunits: (i) one derived from the ? or ? chain of the fibrin and (ii) a second derived from the filaggrin. In addition, the invention comprises an antigenic composition, a method and a kit for the diagnosis of rheumatoid arthritis, from the detection of the autoantibodies generated during the course of said disease.Type: GrantFiled: April 30, 2008Date of Patent: April 21, 2015Assignees: Consejo Superior de Investigaciones Cientificas, Fundacio Clinic per a la Recerca BiomedicaInventors: Isabel Haro Villar, José M. Gomora Elena, Luisa M Perez Rodríguez, Raimon Sanmarti Sala
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Publication number: 20140215644Abstract: The present invention discloses soluble isoforms of CD5 and CD6, which are scavenger-like lymphocyte receptors, for use in the prophylaxis or therapy of disorders or in therapeutic interventions, which would benefit from an exacerbated immune response to either endogenous or exogenous antigens, resulting from a decrease in lymphocyte subpopulations with regulatory functions and/or increase in lymphocyte subpopulations with effector functions. Special disorders are cell growth disorders, and chronic infections of bacterial, viral, fungal or parasitic origin. The invention also provides animal models for the study and the prophylaxis/treatment of autoimmune diseases, cancer, and chronic infections.Type: ApplicationFiled: May 29, 2012Publication date: July 31, 2014Applicants: FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA, UNIVERSITAT DE BARCELONA, HOSPITAL CLINIC I PROVINCIAL DE BARCELONAInventors: Francisco Lozano Soto, Vanessa Gabriela Martinez, Rafael Fenutria Aumesquet
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Patent number: 8404633Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.Type: GrantFiled: June 19, 2009Date of Patent: March 26, 2013Assignees: Hospital Clinic I Provincial de Barcelona, Universitat de Barcelona, Fundacio Clinic per a la Recerca BiomedicaInventors: Francisco Lozano Soto, Jorge Vera Fernandez
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Publication number: 20110295062Abstract: Equipment for infrared vision of anatomical structures applicable to assist the physicians in endoscopic, fetoscopic or laparoscopic operations and methods for signal processing to enhance said vision, comprising two units that work together: a multimodal or multispectral imaging unit, constituted by a device comprising an endoscope or fetoscope or laparoscope, and additional optical systems to acquire multimodal images of the interior of the patient's body; and an image processing unit, to which said images are transferred, comprising processing devices with a navigation interface which process said images and display the patient's enhanced anatomical map image and the endoscope location, equipped with hardware and software that apply at least five different vision-enhancing methods, namely normalization, segmentation, tracking, mapping and fusion.Type: ApplicationFiled: December 10, 2009Publication date: December 1, 2011Applicants: Fundacio Clinic Per A La Recerca Biomedica Fcrb, Universitat De Barcelona, Hospital Clinic I Provincial De BarcelonaInventors: Eduard Gratacós Solsona, Iván Amat Roldán
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Publication number: 20110195894Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.Type: ApplicationFiled: June 19, 2009Publication date: August 11, 2011Applicants: HOSPITAL CLINIC I PROVINCIAL DE BARCELONA, FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA, UNIVERSITAT DE BARCELONAInventors: Francisco Lozano Soto, Jorge Vera Fernandez
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Publication number: 20110027296Abstract: The invention relates to the use of an antibody or a fragment thereof, specific against substance P, for the manufacture of a medicament for therapeutic treatment of a cancer expressing NK1 receptor and/or a ErbB receptor family member (i.e. the epidermal growth factor receptors family), by direct administration to a mammal, including a human. The administration of an antibody against substance P to a panel of breast cancer cell lines, inhibits HER2 activation and expression, causing a downregulation of different genes involved in cell cycle progression, like cyclin D1, cyclin E, cdk4 and cdk2. A decrease in proliferation and an arrest in G1 phase of cell cycle are observed. On the other hand, the antibody causes an induction of apoptosis.Type: ApplicationFiled: April 8, 2009Publication date: February 3, 2011Applicants: UNIVERSIDAD DE BARCELONA, HOSPITAL CLINIC I PROVINCIAL DE BARCELONA, FUNDACIÓ CLÍNIC PER A LA RECERCA BIOMÈDICA;Inventors: Vanessa Almendro Navarro, Pere Gascon Vilaplana