Patents Assigned to Fundacio Privada Centre De Regulacio Genomica (CRG)
  • VARIANTS OF THE TNF SUPERFAMILY AND USES THEREOF
    Publication number: 20140178329
    Abstract: Described are novel variants of APRIL that modulate signaling via receptor-specific agonist activity, and nucleic acids encoding these variant proteins. Further described is the use of these novel proteins in the treatment of APRIL-associated disorders, in particular, pathologies of the immune system and oncological disorders.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 26, 2014
    Applicants: Institucio Catalana de Recerca I Estudis Avancats (ICREA), Fundacio Privada Centre de Regulacio Genomica (CRG)
    Inventors: Luis Serrano Pubul, Albert Martinus Van Der Sloot, Jan Paul Medema, Fiona Clare Kimberley
  • CYTOKINE DESIGN
    Publication number: 20110200552
    Abstract: The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1) over the decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4).
    Type: Application
    Filed: November 21, 2008
    Publication date: August 18, 2011
    Applicants: RIJKSUNIVERSITEIT GRONINGEN, NATIONAL UNIVERSITY OF IRELAND, GALWAY, TRISKEL THERAPEUTICS B.V, Fundacio Privada Centre De Regulacio Genomica (CRG), Institucio Catalana De Recerca I Estudis Avancats (ICREA)
    Inventors: Carlos Ricardo Rodrigues Dos Reis, Wilhelmus Johannes Quax, Afshin Samali, Eva Szegezdi, Robbert Hans Cool, Albert Martinus Van Der Sloot, Luis Serrano, Vicente Tur