Patents Assigned to FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
  • Publication number: 20130190367
    Abstract: Compounds of formula (I) or their pharmaceutically acceptable salts, or their stereoisomers or mixtures of stereoisomers, where: R1 is selected from the group consisting of: phenyl, and phenyl mono-, di-, or tri-substituted by a radical independently selected from the group consisting of F, Cl, Br, I, (C1-C6)-alkyl, COO-(C1-C6)-alkyl, and (C1-C6)-alkoxy; and R2 is a radical selected from the same group as R1, further including a phenyl substituted in 4-position by a radical independently selected from the group consisting of —O(CH2)CONH(CH2)3CH3 and OCH2COOC(CH3)3, a biphenyl-4-yl, thiazol-2-yl, and a thiazol-2-yl mono- or di-substituted by a radical selected from F and phenyl; inhibit cell proliferation of tumor cells independently of p53 protein and may also induce apoptosis in several tumor cells independently of p53 protein, being useful for the treatment of several types of cancer.
    Type: Application
    Filed: August 29, 2011
    Publication date: July 25, 2013
    Applicants: UNIVERSITAT DE BARCELONA, FUNDACIO PRIVADA INSTITUT DE RECERCA BIOMEDICA DE BARCELONA, FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE, FUNDACIO PRIVADA PARC CIENTÍFIC DE BARCELONA
    Inventors: Joan Gil Santano, Rodolfo Lavilla Grífols, Fernando Albericio Palomera, Alba Pérez Perarnau, Sara Preciado Gallego, Diana Mª González Gironès, Daniel Iglesias Serret, Rosario Ramón Albalate