Patents Assigned to FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA
  • Method of treating HIV-1 infection utilizing a multiepitope T cell immunogen comprising Gag, Pol, Vif, and Nef epitopes
    Patent number: 11919926
    Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: March 5, 2024
    Assignees: ESTEVE PHARMACEUTICALS, S.A., FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA
    Inventors: Christian Brander, Beatriz Mothe Pujadas, Anuska Llano
  • Immunogens for HIV vaccination
    Patent number: 10815278
    Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including said immunogens.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 27, 2020
    Assignees: Laboratorios del Dr. Esteve S.A., Fundació Privada Institut de Recerca de La Sida—Caixa
    Inventors: Christian Brander, Beatriz Mothe Pujadas, Anuska Llano
  • Immunogens for HIV vaccination
    Patent number: 9988425
    Abstract: The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of AIDS and its related opportunistic diseases. The invention also relates to isolated nucleic acids, vectors and host cells expressing these immunogens as well as vaccines including the immunogens.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: June 5, 2018
    Assignees: Laboratories Del Dr. Esteve S.A., Fundació Privada Institut De Recerca De La Sida—CAIXA
    Inventors: Christian Brander, Beatriz Mothe Pujadas, Anuska Llano
  • Methods for identifying HIV neutralizing antibodies
    Patent number: 9952218
    Abstract: The present invention relates to an in vitro method for determining HIV neutralizing antibodies in a sample. It further relates to a fusion protein to be used in said method and a nucleic acid encoding said fusion protein.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: April 24, 2018
    Assignees: LABORATORIOS DEL DR. ESTEVE S.A., FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA
    Inventors: Julián Miguel Blanco Arbués, Jorge Carrillo Molina
  • Method for blocking HIV entry into dendritic cells by inhibiting sialoadhesin-sialyllactose binding interactions with gangliosides
    Patent number: 9789130
    Abstract: The present invention refers to methods and compositions to prevent viral entry into cells expressing the CD169/sialoadhesin surface receptor by inhibiting the coupling of the sialyllactose molecule contained in the viral membrane gangliosides to the CD 169/sialoadhesin receptor. The invention also pertains to vaccine compositions based on dendritic cells loaded with an antigen of interest whereby the vaccine is provided together with a composition capable of preventing viral entry into cells expressing the CD169/sialoadhesin. Moreover, the invention relates to diagnostic and therapeutic compositions that can be specifically delivered to enveloped virions wherein the diagnostic/therapeutic agent is coupled to CD169/sialoadhesin.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: October 17, 2017
    Assignees: LABORATORIOS DEL DR. ESTEVE, S.A., FUNDACIÓ PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
    Inventors: Nuria Izquierdo Useros, Hans-Georg Krauesslich, Maier Lorizate, Javier Martinez Picado
  • Method for monitoring HIV specific T cell responses
    Patent number: 9709577
    Abstract: The invention relates to a method and a diagnostic kit for monitoring HIV specific T cell responses and identifying subjects capable of controlling HIV progression or preventing HIV infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a large set of effector functions. The method is also suitable to detect T cell responses of any desirable cytokine or combination of cytokines to any pathogen.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: July 18, 2017
    Assignees: LABORATORIOS DEL DR. ESTEVE S.A., FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA—CAIXA, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIOS AVANÇATS
    Inventors: Marta Ruiz Riol, Christian Brander, Javier Ibarrondo