Abstract: Use of a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist/ inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level.
Type:
Grant
Filed:
December 22, 2015
Date of Patent:
March 14, 2017
Assignee:
Fundacion Del Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion (FUHNPAIIN)
Inventors:
Antonio Oliviero, Juan de Los Reyes Aguilar Lepe, Mario Rotondi, Eduardo Molina Holgado, Luca Chiovato, Guglielmo Foffani, Laura Mordillo Mateos, Angel Lozano Sicilia, Daniel Garcia Ovejero, Angel Arevalo Martin, Yolanda Perez Borrego
Abstract: Use of a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist/ inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level.
Type:
Application
Filed:
December 22, 2015
Publication date:
April 21, 2016
Applicant:
Fundacion Del Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion (FUHNPAIIN)
Inventors:
Antonio Oliviero, Juan de Los Reyes Aguilar Lepe, Mario Rotondi, Eduardo Molina Holgado, Luca Chiovato, Guglielmo Foffani, Laura Mordillo Mateos, Angel Lozano Sicilia, Daniel Garcia Ovejero, Angel Arevalo Martin, Yolanda Perez Borrego
Abstract: Use of a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for the preparation of drugs useful for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level, as well as a method for increasing motor neuron excitability through the administration of a CB1 antagonist/inverse agonist receptors, and to the use of a pharmaceutical composition which comprises a CB1 receptor antagonist and/or inverse agonist, preferably rimonabant, for increasing motor neuron excitability in the cerebral cortex and/or in the brain stem and/or at the spinal level.
Type:
Grant
Filed:
January 11, 2010
Date of Patent:
January 19, 2016
Assignee:
Fundacion del Hospital Nacional de Paraplejicos para la investigacion y la integracion (Fuhnpaiin)
Inventors:
Antonio Oliviero, Juan de los Reyes Aguilar Lepe, Mario Rotondi, Eduardo Molina Holgado, Luca Chiovato, Guglielmo Foffani, Laura Mordillo Mateos, Ángel Lozano Sicilia, Daniel García Ovejero, Ángel Arévalo Martín, Yolanda Pérez Borrego