Abstract: The present invention is related to acyclic sulfamide derivatives, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulfamide derivatives are also useful for cosmetic use.
Type:
Grant
Filed:
January 26, 2007
Date of Patent:
May 29, 2012
Assignees:
Fundacion Imabis. Instituto Mediterraneo para el Avance de la Biotecnologia y la Investigacion Sanitaria, Consejo Superior de Investigaciones Cientificas
Inventors:
Fernando Antonio Rodriguez de Fonseca, Manuel Macias Gonzalez, Javier Pavon Moron, María Pilar Goya-Laza, Juan Antonio Paez Prosper, Carolina Cano Ramos
Abstract: The present invention is related to acyclic sulphamide derivatives of formula (I), wherein R1 and R2 may be the same or different, when R1 and R2 are different, R1 is a linear C12-C20 alkyl group or a linear C12-C20 alkenyl group comprising 1, 2, 3 or 4 double bonds; and R2 is a hydrogen atom or a C1-C4 alkyl group, or when R1 and R2 are the same, R1 and R2 are a linear C14-C20 alkyl group or a linear C14-C20 alkenyl group with 1, 2, 3 or 4 double bonds, and pharmaceutically acceptable salts, solvates and hydrates thereof, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulphamide derivatives are also useful for cosmetic use for reducing subcutaneous fat.
Type:
Application
Filed:
January 26, 2007
Publication date:
July 15, 2010
Applicants:
Fundacion Imabis. Instituto Mediterraneo Para El Avance De La Biotecnologia y La Investigacion Sanitaria, Consejo Superior De Investigaciones Cientificas
Inventors:
Fernando Antonio RODRIGUEZ DE FONSECA, Manuel MACIAS GONZALEZ, Javier PAVON MORON, María Pilar GOYA-LAZA, Juan Antonio PAEZ PROSPER, Carolina CANO RAMOS
Abstract: The present invention is related to acyclic sulphamide derivatives of formula (I), wherein R1 and R2 may be the same or different, when R1 and R2 are different, R1 is a linear C12-C20 alkyl group or a linear C12-C20 alkenyl group comprising 1, 2, 3 or 4 double bonds; and R2 is a hydrogen atom or a C1-C4 alkyl group, or when R1 and R2 are the same, R1 and R2 are a linear C14-C20 alkyl group or a linear C14-C20 alkenyl group with 1, 2, 3 or 4 double bonds, and pharmaceutically acceptable salts, solvates and hydrates thereof, useful for the manufacture of a medicament for satiety induction and ingestion control, corporal fat modulation and lipidic metabolism regulation and for the manufacture of a medicament for the treatment or prevention of diabetes and cardiovascular diseases. The acyclic sulphamide derivatives are also useful for cosmetic use for reducing subcutaneous fat.
Type:
Application
Filed:
January 26, 2007
Publication date:
February 25, 2010
Applicants:
Fundacion Imabis. Instituto Mediterraneo Para El Avance De La Biotecnologia y La Investigacion Sanitaria, Consejo Superior De Investigaciones Cientificas
Inventors:
Fernando Antonio RODRIGUEZ DE FONSECA, Manuel MACIAS GONZALEZ, Javier PAVON MORON, María Pilar GOYA-LAZA, Juan Antonio PAEZ PROSPER, Carolina CANO RAMOS