Patents Assigned to FUNDACION INSTITUTO LELOIR (FIL)
  • SPARC (secreted protein, acidic and rich in cysteine), a new target for the treatment and prevention of acute liver failure
    Patent number: 10385114
    Abstract: The invention relates to the identification of Secreted Protein, Acidic and Rich in Cysteine (SPARC) as a new therapeutic target in patients with fulminant hepatitis and allows the development of a strategy destined to protect the liver form damage. The invention relates to the treatment of acute liver failure or fulminant hepatitis by administering to a subject in need thereof an agent that inhibits at least partially the expression of SPARC and/or interferes with its biological function.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: August 20, 2019
    Assignees: INIS BIOTECH LLC, CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET), FUNDACION INSTITUTO LELOIR (FIL), ASOCIACION CIVIL DE ESTUDIOS SUPERIORES (ACES)
    Inventors: Guillermo Daniel Mazzolini, Estanislao Peixoto, Jorge Aquino, Maria C. Atorrasagasti, Osvaldo Podhjacer