Abstract: Disclosed herein are heterocyclic compounds according to formula (I) having the structure that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-HLL interaction. Also disclosed are pharmaceutical compositions that include compounds according to formula (I). Methods of using the menin-HLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.
Type:
Grant
Filed:
June 18, 2021
Date of Patent:
July 18, 2023
Assignee:
BIOMEA FUSION, LLC
Inventors:
Thomas Butler, Jim Palmer, Ravi Upasani, Matthew Welsch, Sridhar Vempati, Brendan Kelly, Edward Painter
Abstract: An implant and method for posterior sacroiliac fusion having a plate for placement across the posterior surface of the sacroiliac joint, a transverse pin to slide through the plate and transverse the joint as well as provide an aperture to receive bone graft, and a sacral screw to be inserted through the plate.
Type:
Grant
Filed:
March 2, 2020
Date of Patent:
January 3, 2023
Assignee:
SAIL Fusion, LLC
Inventors:
Benjamin Arnold, Brian Bowman, Kristen Ybarra, Vikas Patel
Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL inter-action; or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
December 31, 2019
Date of Patent:
August 10, 2021
Assignee:
BIOMEA FUSION, LLC
Inventors:
Thomas Butler, Jim Palmer, Ravi Upasani, Matthew Welsch, Sridhar Vempati, Brendan Kelly, Edward Painter
Abstract: A massage kit having a foam roller, a massage device, and a removable cover. The massage device includes a flat bottom surface with a curved top surface. Protrusions extend from the massage device and are configured to interact with the removable cover to hold the cover in place on the top surface or the bottom surface of the massage device. The roller includes an opening sized and dimensioned to receive the massage device.
Abstract: An implant and method for posterior sacroiliac fusion having a plate for placement across the posterior surface of the sacroiliac joint, a transverse pin to slide through the plate and transverse the joint as well as provide an aperture to receive bone graft, and a sacral screw to be inserted through the plate.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
April 28, 2020
Assignee:
SAIL FUSION, LLC
Inventors:
Benjamin Arnold, Brian Bowman, Kristen Pena, Vikas Patel
Abstract: An implant and method for posterior sacroiliac fusion having a plate for placement across the posterior surface of the sacroiliac joint, a transverse pin to slide through the plate and transverse the joint as well as provide an aperture to receive bone graft, and a sacral screw to be inserted through the plate.
Type:
Grant
Filed:
July 18, 2017
Date of Patent:
March 31, 2020
Assignee:
SAIL FUSION, LLC
Inventors:
Benjamin Arnold, Brian Bowman, Kristen Pena, Vikas Patel
Abstract: A reaction arm for use with a torque generating device, the reaction arm including a reaction bar, and a body portion having a first internal diameter, and having formed on an internal surface thereof a female spline having a second internal diameter and a guide bushing having a third internal diameter, the first, second, and third internal diameter being distinctly sized.